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E4T665 (E4T665_PALPW) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Palpr_2072 EMBL ADQ80209.1
OrganismPaludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4) [Complete proteome] [HAMAP] EMBL ADQ80209.1
Taxonomic identifier694427 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePaludibacter

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 321201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding149 – 20456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2751Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2881Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2881Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2901Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E4T665 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: D20FA5AF6B1B266C

FASTA32535,487
        10         20         30         40         50         60 
MKKNIAIVAG GNSSEVVVSL DSVAGLYSFM DKERYNLFIV TIVGSVWQVE LSDDEKITID 

        70         80         90        100        110        120 
KNDFSFTKSG VKTLFDFAYI TIHGTPGENG ILQGYFELIG LPYSCCGVLA AAITFNKFTC 

       130        140        150        160        170        180 
NQYLKGFGVR VSDSLVLRAG QTVSDEEVAQ KIGFPCFVKP NVGGSSFGVT KVKSIEQLQP 

       190        200        210        220        230        240 
AIEKAFTEGD EVMIEAFMSG TEITCGIYKT KTKTQVLPIT EVVPKNEFFD FDAKYKGEVE 

       250        260        270        280        290        300 
EITPARISTS LTERVQKLTS AIYDILGCKG IVRIDYIISE GDVINLLEVN TTPGMTATSF 

       310        320 
IPQQVAAAGL DIKDVMTEII ENELV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002345 Genomic DNA. Translation: ADQ80209.1.
RefSeqYP_004043194.1. NC_014734.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ80209; ADQ80209; Palpr_2072.
GeneID9999736.
KEGGppn:Palpr_2072.
PATRIC45312232. VBIPalPro155528_2110.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.

Enzyme and pathway databases

BioCycPPRO694427:GHIQ-2125-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4T665_PALPW
AccessionPrimary (citable) accession number: E4T665
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)