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Protein

Isocitrate dehydrogenase [NADP]

Gene

Palpr_1044

Organism
Paludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87SubstrateUniRule annotation1
Binding sitei92NADPUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Sitei149Critical for catalysisUniRule annotation1
Sitei220Critical for catalysisUniRule annotation1
Metal bindingi260Magnesium or manganeseUniRule annotation1
Binding sitei268NADPUniRule annotation1
Metal bindingi283Magnesium or manganeseUniRule annotation1
Binding sitei336NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 87NADPUniRule annotation3
Nucleotide bindingi318 – 323NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Palpr_1044Imported
OrganismiPaludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)Imported
Taxonomic identifieri694427 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPaludibacteraceaePaludibacter
Proteomesi
  • UP000008718 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi694427.Palpr_1044

Structurei

3D structure databases

ProteinModelPortaliE4T399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 408Iso_dhInterPro annotationAdd BLAST390

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 110Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5N Bacteria
COG0538 LUCA
HOGENOMiHOG000019858
KOiK00031
OMAiAMGMYNQ
OrthoDBiPOG091H0JP0

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

E4T399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDSRLQYM KEKIKVTKPV VELDGDEMTR IIWAFIKEQL ILPYLDLDIK
60 70 80 90 100
YYDLGIENRD LTNDEVTIEA ANAINKYNVG IKCATITPDE ARVEEFGLKK
110 120 130 140 150
MWKSPNGTLR NIIGGTVFRE PIICNNVPRY VQGWTKPIVI GRHAFGDQYK
160 170 180 190 200
ATDTVIKGKG TLKMTFTNEA GETKEWEVYN FNGDGVAMTM YNTDESIYGF
210 220 230 240 250
ARSSFQVALE KKWPLYLSTK NTILKAYDGR FKDIFQEVYE KEFQAAFKEA
260 270 280 290 300
GITYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMS
310 320 330 340 350
SVLVTPDGKT VEAEAAHGTV TRHYRQHQQG KQTSTNPIAS IFAWTRGLMH
360 370 380 390 400
RAKLDNNPEL QSFCEKLEQV CIETVEAGEM TKDLAILIYG EGVTNANYLS
410
TEGFLAALKR NLDKKLA
Length:417
Mass (Da):47,140
Last modified:February 8, 2011 - v1
Checksum:i7372A8E8ED7DA061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002345 Genomic DNA Translation: ADQ79193.1

Genome annotation databases

EnsemblBacteriaiADQ79193; ADQ79193; Palpr_1044
KEGGippn:Palpr_1044

Similar proteinsi

Entry informationi

Entry nameiE4T399_PALPW
AccessioniPrimary (citable) accession number: E4T399
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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