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E4T399 (E4T399_PALPW) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding85 – 873NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding318 – 3236NADP By similarity PIRSR PIRSR000108-4
Region104 – 1107Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2601Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2831Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site871Substrate By similarity PIRSR PIRSR000108-2
Binding site921NADP By similarity PIRSR PIRSR000108-4
Binding site1191Substrate By similarity PIRSR PIRSR000108-2
Binding site1421Substrate By similarity PIRSR PIRSR000108-2
Binding site2681NADP By similarity PIRSR PIRSR000108-4
Binding site3361NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1491Critical for catalysis By similarity
Site2201Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
E4T399 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 7372A8E8ED7DA061

FASTA41747,140
        10         20         30         40         50         60 
MTLDSRLQYM KEKIKVTKPV VELDGDEMTR IIWAFIKEQL ILPYLDLDIK YYDLGIENRD 

        70         80         90        100        110        120 
LTNDEVTIEA ANAINKYNVG IKCATITPDE ARVEEFGLKK MWKSPNGTLR NIIGGTVFRE 

       130        140        150        160        170        180 
PIICNNVPRY VQGWTKPIVI GRHAFGDQYK ATDTVIKGKG TLKMTFTNEA GETKEWEVYN 

       190        200        210        220        230        240 
FNGDGVAMTM YNTDESIYGF ARSSFQVALE KKWPLYLSTK NTILKAYDGR FKDIFQEVYE 

       250        260        270        280        290        300 
KEFQAAFKEA GITYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMS 

       310        320        330        340        350        360 
SVLVTPDGKT VEAEAAHGTV TRHYRQHQQG KQTSTNPIAS IFAWTRGLMH RAKLDNNPEL 

       370        380        390        400        410 
QSFCEKLEQV CIETVEAGEM TKDLAILIYG EGVTNANYLS TEGFLAALKR NLDKKLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002345 Genomic DNA. Translation: ADQ79193.1.
RefSeqYP_004042178.1. NC_014734.1.

3D structure databases

ProteinModelPortalE4T399.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ79193; ADQ79193; Palpr_1044.
GeneID9998678.
KEGGppn:Palpr_1044.
PATRIC45310081. VBIPalPro155528_1067.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycPPRO694427:GHIQ-1067-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4T399_PALPW
AccessionPrimary (citable) accession number: E4T399
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)