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E4T399

- E4T399_PALPW

UniProt

E4T399 - E4T399_PALPW

Protein

Isocitrate dehydrogenase [NADP]

Gene

Palpr_1044

Organism
Paludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871Substrate
    Binding sitei92 – 921NADPUniRule annotation
    Binding sitei119 – 1191Substrate
    Binding sitei142 – 1421Substrate
    Sitei149 – 1491Critical for catalysisUniRule annotation
    Sitei220 – 2201Critical for catalysisUniRule annotation
    Metal bindingi260 – 2601Magnesium or manganeseUniRule annotation
    Binding sitei268 – 2681NADPUniRule annotation
    Metal bindingi283 – 2831Magnesium or manganeseUniRule annotation
    Binding sitei336 – 3361NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi85 – 873NADPUniRule annotation
    Nucleotide bindingi318 – 3236NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciPPRO694427:GHIQ-1067-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Palpr_1044Imported
    OrganismiPaludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)Imported
    Taxonomic identifieri694427 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePaludibacter
    ProteomesiUP000008718: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE4T399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni104 – 1107Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4T399-1 [UniParc]FASTAAdd to Basket

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    MTLDSRLQYM KEKIKVTKPV VELDGDEMTR IIWAFIKEQL ILPYLDLDIK    50
    YYDLGIENRD LTNDEVTIEA ANAINKYNVG IKCATITPDE ARVEEFGLKK 100
    MWKSPNGTLR NIIGGTVFRE PIICNNVPRY VQGWTKPIVI GRHAFGDQYK 150
    ATDTVIKGKG TLKMTFTNEA GETKEWEVYN FNGDGVAMTM YNTDESIYGF 200
    ARSSFQVALE KKWPLYLSTK NTILKAYDGR FKDIFQEVYE KEFQAAFKEA 250
    GITYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMS 300
    SVLVTPDGKT VEAEAAHGTV TRHYRQHQQG KQTSTNPIAS IFAWTRGLMH 350
    RAKLDNNPEL QSFCEKLEQV CIETVEAGEM TKDLAILIYG EGVTNANYLS 400
    TEGFLAALKR NLDKKLA 417
    Length:417
    Mass (Da):47,140
    Last modified:February 8, 2011 - v1
    Checksum:i7372A8E8ED7DA061
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002345 Genomic DNA. Translation: ADQ79193.1.
    RefSeqiYP_004042178.1. NC_014734.1.

    Genome annotation databases

    EnsemblBacteriaiADQ79193; ADQ79193; Palpr_1044.
    GeneIDi9998678.
    KEGGippn:Palpr_1044.
    PATRICi45310081. VBIPalPro155528_1067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002345 Genomic DNA. Translation: ADQ79193.1 .
    RefSeqi YP_004042178.1. NC_014734.1.

    3D structure databases

    ProteinModelPortali E4T399.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ79193 ; ADQ79193 ; Palpr_1044 .
    GeneIDi 9998678.
    KEGGi ppn:Palpr_1044.
    PATRICi 45310081. VBIPalPro155528_1067.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.

    Enzyme and pathway databases

    BioCyci PPRO694427:GHIQ-1067-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WB4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17365 / JCM 13257 / WB4Imported.

    Entry informationi

    Entry nameiE4T399_PALPW
    AccessioniPrimary (citable) accession number: E4T399
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3