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E4T399

- E4T399_PALPW

UniProt

E4T399 - E4T399_PALPW

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Palpr_1044
Organism
Paludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarityUniRule annotation
Binding sitei92 – 921NADP By similarityUniRule annotation
Binding sitei119 – 1191Substrate By similarityUniRule annotation
Binding sitei142 – 1421Substrate By similarityUniRule annotation
Sitei149 – 1491Critical for catalysis By similarityUniRule annotation
Sitei220 – 2201Critical for catalysis By similarityUniRule annotation
Metal bindingi260 – 2601Magnesium or manganese By similarityUniRule annotation
Binding sitei268 – 2681NADP By similarityUniRule annotation
Metal bindingi283 – 2831Magnesium or manganese By similarityUniRule annotation
Binding sitei336 – 3361NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 873NADP By similarityUniRule annotation
Nucleotide bindingi318 – 3236NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPPRO694427:GHIQ-1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Palpr_1044Imported
OrganismiPaludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)Imported
Taxonomic identifieri694427 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePaludibacter
ProteomesiUP000008718: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4T399.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1107Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4T399-1 [UniParc]FASTAAdd to Basket

« Hide

MTLDSRLQYM KEKIKVTKPV VELDGDEMTR IIWAFIKEQL ILPYLDLDIK    50
YYDLGIENRD LTNDEVTIEA ANAINKYNVG IKCATITPDE ARVEEFGLKK 100
MWKSPNGTLR NIIGGTVFRE PIICNNVPRY VQGWTKPIVI GRHAFGDQYK 150
ATDTVIKGKG TLKMTFTNEA GETKEWEVYN FNGDGVAMTM YNTDESIYGF 200
ARSSFQVALE KKWPLYLSTK NTILKAYDGR FKDIFQEVYE KEFQAAFKEA 250
GITYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMS 300
SVLVTPDGKT VEAEAAHGTV TRHYRQHQQG KQTSTNPIAS IFAWTRGLMH 350
RAKLDNNPEL QSFCEKLEQV CIETVEAGEM TKDLAILIYG EGVTNANYLS 400
TEGFLAALKR NLDKKLA 417
Length:417
Mass (Da):47,140
Last modified:February 8, 2011 - v1
Checksum:i7372A8E8ED7DA061
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002345 Genomic DNA. Translation: ADQ79193.1.
RefSeqiYP_004042178.1. NC_014734.1.

Genome annotation databases

EnsemblBacteriaiADQ79193; ADQ79193; Palpr_1044.
GeneIDi9998678.
KEGGippn:Palpr_1044.
PATRICi45310081. VBIPalPro155528_1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002345 Genomic DNA. Translation: ADQ79193.1 .
RefSeqi YP_004042178.1. NC_014734.1.

3D structure databases

ProteinModelPortali E4T399.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ79193 ; ADQ79193 ; Palpr_1044 .
GeneIDi 9998678.
KEGGi ppn:Palpr_1044.
PATRICi 45310081. VBIPalPro155528_1067.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci PPRO694427:GHIQ-1067-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WB4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17365 / JCM 13257 / WB4.

Entry informationi

Entry nameiE4T399_PALPW
AccessioniPrimary (citable) accession number: E4T399
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3