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Protein

Isocitrate dehydrogenase [NADP]

Gene

Palpr_1044

Organism
Paludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei92 – 921NADPUniRule annotation
Binding sitei119 – 1191SubstrateUniRule annotation
Binding sitei142 – 1421SubstrateUniRule annotation
Sitei149 – 1491Critical for catalysisUniRule annotation
Sitei220 – 2201Critical for catalysisUniRule annotation
Metal bindingi260 – 2601Magnesium or manganeseUniRule annotation
Binding sitei268 – 2681NADPUniRule annotation
Metal bindingi283 – 2831Magnesium or manganeseUniRule annotation
Binding sitei336 – 3361NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 873NADPUniRule annotation
Nucleotide bindingi318 – 3236NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPPRO694427:GHIQ-1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Palpr_1044Imported
OrganismiPaludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)Imported
Taxonomic identifieri694427 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePaludibacter
ProteomesiUP000008718: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4T399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1107Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiQVIEHDV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4T399-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLDSRLQYM KEKIKVTKPV VELDGDEMTR IIWAFIKEQL ILPYLDLDIK
60 70 80 90 100
YYDLGIENRD LTNDEVTIEA ANAINKYNVG IKCATITPDE ARVEEFGLKK
110 120 130 140 150
MWKSPNGTLR NIIGGTVFRE PIICNNVPRY VQGWTKPIVI GRHAFGDQYK
160 170 180 190 200
ATDTVIKGKG TLKMTFTNEA GETKEWEVYN FNGDGVAMTM YNTDESIYGF
210 220 230 240 250
ARSSFQVALE KKWPLYLSTK NTILKAYDGR FKDIFQEVYE KEFQAAFKEA
260 270 280 290 300
GITYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMS
310 320 330 340 350
SVLVTPDGKT VEAEAAHGTV TRHYRQHQQG KQTSTNPIAS IFAWTRGLMH
360 370 380 390 400
RAKLDNNPEL QSFCEKLEQV CIETVEAGEM TKDLAILIYG EGVTNANYLS
410
TEGFLAALKR NLDKKLA
Length:417
Mass (Da):47,140
Last modified:February 8, 2011 - v1
Checksum:i7372A8E8ED7DA061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002345 Genomic DNA. Translation: ADQ79193.1.
RefSeqiWP_013444562.1. NC_014734.1.
YP_004042178.1. NC_014734.1.

Genome annotation databases

EnsemblBacteriaiADQ79193; ADQ79193; Palpr_1044.
GeneIDi9998678.
KEGGippn:Palpr_1044.
PATRICi45310081. VBIPalPro155528_1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002345 Genomic DNA. Translation: ADQ79193.1.
RefSeqiWP_013444562.1. NC_014734.1.
YP_004042178.1. NC_014734.1.

3D structure databases

ProteinModelPortaliE4T399.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADQ79193; ADQ79193; Palpr_1044.
GeneIDi9998678.
KEGGippn:Palpr_1044.
PATRICi45310081. VBIPalPro155528_1067.

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiQVIEHDV.

Enzyme and pathway databases

BioCyciPPRO694427:GHIQ-1067-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WB4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17365 / JCM 13257 / WB4Imported.

Entry informationi

Entry nameiE4T399_PALPW
AccessioniPrimary (citable) accession number: E4T399
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.