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E4T399

- E4T399_PALPW

UniProt

E4T399 - E4T399_PALPW

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Palpr_1044

Organism
Paludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921NADPUniRule annotation
Sitei149 – 1491Critical for catalysisUniRule annotation
Sitei220 – 2201Critical for catalysisUniRule annotation
Metal bindingi260 – 2601Magnesium or manganeseUniRule annotation
Binding sitei268 – 2681NADPUniRule annotation
Metal bindingi283 – 2831Magnesium or manganeseUniRule annotation
Binding sitei336 – 3361NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 873NADPUniRule annotation
Nucleotide bindingi318 – 3236NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPPRO694427:GHIQ-1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Palpr_1044Imported
OrganismiPaludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)Imported
Taxonomic identifieri694427 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePaludibacter
ProteomesiUP000008718: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4T399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1107Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4T399-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLDSRLQYM KEKIKVTKPV VELDGDEMTR IIWAFIKEQL ILPYLDLDIK
60 70 80 90 100
YYDLGIENRD LTNDEVTIEA ANAINKYNVG IKCATITPDE ARVEEFGLKK
110 120 130 140 150
MWKSPNGTLR NIIGGTVFRE PIICNNVPRY VQGWTKPIVI GRHAFGDQYK
160 170 180 190 200
ATDTVIKGKG TLKMTFTNEA GETKEWEVYN FNGDGVAMTM YNTDESIYGF
210 220 230 240 250
ARSSFQVALE KKWPLYLSTK NTILKAYDGR FKDIFQEVYE KEFQAAFKEA
260 270 280 290 300
GITYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMS
310 320 330 340 350
SVLVTPDGKT VEAEAAHGTV TRHYRQHQQG KQTSTNPIAS IFAWTRGLMH
360 370 380 390 400
RAKLDNNPEL QSFCEKLEQV CIETVEAGEM TKDLAILIYG EGVTNANYLS
410
TEGFLAALKR NLDKKLA
Length:417
Mass (Da):47,140
Last modified:February 8, 2011 - v1
Checksum:i7372A8E8ED7DA061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002345 Genomic DNA. Translation: ADQ79193.1.
RefSeqiYP_004042178.1. NC_014734.1.

Genome annotation databases

EnsemblBacteriaiADQ79193; ADQ79193; Palpr_1044.
GeneIDi9998678.
KEGGippn:Palpr_1044.
PATRICi45310081. VBIPalPro155528_1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002345 Genomic DNA. Translation: ADQ79193.1 .
RefSeqi YP_004042178.1. NC_014734.1.

3D structure databases

ProteinModelPortali E4T399.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ79193 ; ADQ79193 ; Palpr_1044 .
GeneIDi 9998678.
KEGGi ppn:Palpr_1044.
PATRICi 45310081. VBIPalPro155528_1067.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci PPRO694427:GHIQ-1067-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WB4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17365 / JCM 13257 / WB4Imported.

Entry informationi

Entry nameiE4T399_PALPW
AccessioniPrimary (citable) accession number: E4T399
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3