UniProtKB - E4SY07 (E4SY07_LACDN)
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Protein
Thymidine kinase
Gene
tdk
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ND02)
Status
Functioni
Catalytic activityi
ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 94 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 151 | ZincUniRule annotation | 1 | |
Metal bindingi | 154 | ZincUniRule annotation | 1 | |
Metal bindingi | 188 | ZincUniRule annotation | 1 | |
Metal bindingi | 191 | ZincUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 9 – 16 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 93 – 96 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- thymidine kinase activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseUniRule annotationImported, Transferase |
Biological process | DNA synthesisUniRule annotation |
Ligand | ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tdkUniRule annotationImported Ordered Locus Names:LDBND_0631Imported |
Organismi | Lactobacillus delbrueckii subsp. bulgaricus (strain ND02)Imported |
Taxonomic identifieri | 767455 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Homotetramer.UniRule annotation
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidine kinase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000076391. |
KOi | K00857. |
OMAi | KEQFGWI. |
OrthoDBi | POG091H0659. |
Family and domain databases
HAMAPi | MF_00124. Thymidine_kinase. 1 hit. |
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. |
PANTHERi | PTHR11441. PTHR11441. 1 hit. |
Pfami | View protein in Pfam PF00265. TK. 1 hit. |
PIRSFi | PIRSF035805. TK_cell. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS00603. TK_CELLULAR_TYPE. 1 hit. |
i Sequence
Sequence statusi: Complete.
E4SY07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQFFFEYGA MGSGKTIEIL KVAHNYEIQG RKVALLTSSV DTRSGRGVVA
60 70 80 90 100
SRIGLSRSAQ PIEPDLDLFD YITALNQQEQ ESDGHPLAAV LIDEAQFLKK
110 120 130 140 150
AQVIQCARVV DDLHIPVMAF GLKNDFQNHL FEGSEYLLLY ADKIEEMKTI
160 170 180 190 200
CHFCGHKATM ALRYKDGLPV YEGEQVQIGG DEAYYPVCRF HYFHPDQARD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP002341 Genomic DNA. Translation: ADQ60678.1. |
RefSeqi | WP_013439306.1. NC_014727.1. |
Genome annotation databases
EnsemblBacteriai | ADQ60678; ADQ60678; LDBND_0631. |
KEGGi | lde:LDBND_0631. |
PATRICi | fig|767455.3.peg.632. |
Similar proteinsi
Entry informationi
Entry namei | E4SY07_LACDN | |
Accessioni | E4SY07Primary (citable) accession number: E4SY07 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | March 28, 2018 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |