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E4SY07

- E4SY07_LACDN

UniProt

E4SY07 - E4SY07_LACDN

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Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ND02)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptorUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation
Metal bindingi154 – 1541ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation
Metal bindingi191 – 1911ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLDEL767455:GHXE-650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:LDBND_0631Imported
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ND02)Imported
Taxonomic identifieri767455 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000008717: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiAIPITAD.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4SY07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQFFFEYGA MGSGKTIEIL KVAHNYEIQG RKVALLTSSV DTRSGRGVVA
60 70 80 90 100
SRIGLSRSAQ PIEPDLDLFD YITALNQQEQ ESDGHPLAAV LIDEAQFLKK
110 120 130 140 150
AQVIQCARVV DDLHIPVMAF GLKNDFQNHL FEGSEYLLLY ADKIEEMKTI
160 170 180 190 200
CHFCGHKATM ALRYKDGLPV YEGEQVQIGG DEAYYPVCRF HYFHPDQARD
Length:200
Mass (Da):22,552
Last modified:February 8, 2011 - v1
Checksum:i913DF7EC2CA67DBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002341 Genomic DNA. Translation: ADQ60678.1.
RefSeqiYP_004033655.1. NC_014727.1.

Genome annotation databases

EnsemblBacteriaiADQ60678; ADQ60678; LDBND_0631.
GeneIDi9990292.
KEGGilde:LDBND_0631.
PATRICi43080586. VBILacDel160915_0632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002341 Genomic DNA. Translation: ADQ60678.1 .
RefSeqi YP_004033655.1. NC_014727.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ60678 ; ADQ60678 ; LDBND_0631 .
GeneIDi 9990292.
KEGGi lde:LDBND_0631.
PATRICi 43080586. VBILacDel160915_0632.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi AIPITAD.

Enzyme and pathway databases

BioCyci LDEL767455:GHXE-650-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Lactobacillus delbrueckii subsp. bulgaricus strain ND02."
    Chen W., Zhang H., Sun Z., Chen X., Guo Z., Wang J., Wu L., Zhang X., Zhou Z., Sun T., Wang L., Meng H.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ND02Imported.

Entry informationi

Entry nameiE4SY07_LACDN
AccessioniPrimary (citable) accession number: E4SY07
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3