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Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ND02)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptorUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation
Metal bindingi154 – 1541ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation
Metal bindingi191 – 1911ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciLDEL767455:GHXE-650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:LDBND_0631Imported
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ND02)Imported
Taxonomic identifieri767455 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000008717 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
OMAiFFEYGAM.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4SY07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFFFEYGA MGSGKTIEIL KVAHNYEIQG RKVALLTSSV DTRSGRGVVA
60 70 80 90 100
SRIGLSRSAQ PIEPDLDLFD YITALNQQEQ ESDGHPLAAV LIDEAQFLKK
110 120 130 140 150
AQVIQCARVV DDLHIPVMAF GLKNDFQNHL FEGSEYLLLY ADKIEEMKTI
160 170 180 190 200
CHFCGHKATM ALRYKDGLPV YEGEQVQIGG DEAYYPVCRF HYFHPDQARD
Length:200
Mass (Da):22,552
Last modified:February 7, 2011 - v1
Checksum:i913DF7EC2CA67DBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002341 Genomic DNA. Translation: ADQ60678.1.
RefSeqiYP_004033655.1. NC_014727.1.

Genome annotation databases

EnsemblBacteriaiADQ60678; ADQ60678; LDBND_0631.
KEGGilde:LDBND_0631.
PATRICi43080586. VBILacDel160915_0632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002341 Genomic DNA. Translation: ADQ60678.1.
RefSeqiYP_004033655.1. NC_014727.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADQ60678; ADQ60678; LDBND_0631.
KEGGilde:LDBND_0631.
PATRICi43080586. VBILacDel160915_0632.

Phylogenomic databases

HOGENOMiHOG000076391.
OMAiFFEYGAM.

Enzyme and pathway databases

BioCyciLDEL767455:GHXE-650-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Lactobacillus delbrueckii subsp. bulgaricus strain ND02."
    Chen W., Zhang H., Sun Z., Chen X., Guo Z., Wang J., Wu L., Zhang X., Zhou Z., Sun T., Wang L., Meng H.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ND02Imported.

Entry informationi

Entry nameiE4SY07_LACDN
AccessioniPrimary (citable) accession number: E4SY07
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2011
Last sequence update: February 7, 2011
Last modified: March 31, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.