E4SY07 (E4SY07_LACDN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase RuleBase RU000544 HAMAP-Rule MF_00124
EC=2.7.1.21 RuleBase RU000544 HAMAP-Rule MF_00124

Gene names

Name:	tdk HAMAP-Rule MF_00124 EMBL ADQ60678.1
Ordered Locus Names:	LDBND_0631 EMBL ADQ60678.1

Organism

Lactobacillus delbrueckii subsp. bulgaricus (strain ND02) [Complete proteome] [HAMAP] EMBL ADQ60678.1

Taxonomic identifier

767455 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus delbrueckii › Lactobacillus delbrueckii subsp. bulgaricus

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124 SAAS SAAS020634
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00124 SAAS SAAS020634.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP-Rule MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634
Cellular component	Cytoplasm HAMAP-Rule MF_00124 SAAS SAAS020634
Ligand	ATP-binding RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634 Metal-binding HAMAP-Rule MF_00124 SAAS SAAS020634 Nucleotide-binding Zinc HAMAP-Rule MF_00124 SAAS SAAS020634
Molecular function	Kinase RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634 EMBL ADQ60678.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP thymidine kinase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity HAMAP-Rule MF_00124
	Nucleotide binding	93 – 96	4	ATP By similarity HAMAP-Rule MF_00124
Sites
	Active site	94	1	Proton acceptor By similarity HAMAP-Rule MF_00124
	Metal binding	151	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	154	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	188	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	191	1	Zinc By similarity HAMAP-Rule MF_00124

Sequences

	Sequence		Length	Mass (Da)
	E4SY07 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 913DF7EC2CA67DBA	FASTA	200	22,552
	10 20 30 40 50 60 MAQFFFEYGA MGSGKTIEIL KVAHNYEIQG RKVALLTSSV DTRSGRGVVA SRIGLSRSAQ 70 80 90 100 110 120 PIEPDLDLFD YITALNQQEQ ESDGHPLAAV LIDEAQFLKK AQVIQCARVV DDLHIPVMAF 130 140 150 160 170 180 GLKNDFQNHL FEGSEYLLLY ADKIEEMKTI CHFCGHKATM ALRYKDGLPV YEGEQVQIGG 190 200 DEAYYPVCRF HYFHPDQARD

References

[1]

"Complete genome sequence of Lactobacillus delbrueckii subsp. bulgaricus strain ND02." Chen W., Zhang H., Sun Z., Chen X., Guo Z., Wang J., Wu L., Zhang X., Zhou Z., Sun T., Wang L., Meng H. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ND02.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002341 Genomic DNA. Translation: ADQ60678.1.
RefSeq	YP_004033655.1. NC_014727.1.
3D structure databases
ModBase	Search...
MobiDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADQ60678; ADQ60678; LDBND_0631.
GeneID	9990292.
KEGG	lde:LDBND_0631.
PATRIC	43080586. VBILacDel160915_0632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000076391.
KO	K00857.
OMA	AIPITAD.
Enzyme and pathway databases
BioCyc	LDEL767455:GHXE-650-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E4SY07_LACDN

Accession

Primary (citable) accession number: E4SY07

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)