tdk

Functionⁱ

Catalytic activityⁱ

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	94	Proton acceptorUniRule annotation	1
Metal bindingⁱ	151	ZincUniRule annotation	1
Metal bindingⁱ	154	ZincUniRule annotation	1
Metal bindingⁱ	188	ZincUniRule annotation	1
Metal bindingⁱ	191	ZincUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	9 – 16	ATPUniRule annotation		8
Nucleotide bindingⁱ	93 – 96	ATPUniRule annotation		4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-HAMAP
thymidine kinase activity Source: UniProtKB-HAMAP
zinc ion binding Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

DNA biosynthetic process Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	KinaseUniRule annotationImported, Transferase
Biological process	DNA synthesisUniRule annotation
Ligand	ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesⁱ	Name:tdkUniRule annotationImported Ordered Locus Names:LDBND_0631Imported
Organismⁱ	Lactobacillus delbrueckii subsp. bulgaricus (strain ND02)Imported
Taxonomic identifierⁱ	767455 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus delbrueckii ›
Proteomesⁱ	UP000008717 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00124

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Homotetramer.UniRule annotation

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000076391.
KEGG Orthology (KO) More...KOⁱ	K00857.
OMAⁱ	KEQFGWI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0659.

Family and domain databases

HAMAPⁱ	MF_00124. Thymidine_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS.
PANTHERⁱ	PTHR11441. PTHR11441. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00265. TK. 1 hit.
PIRSFⁱ	PIRSF035805. TK_cell. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E4SY07-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQFFFEYGA MGSGKTIEIL KVAHNYEIQG RKVALLTSSV DTRSGRGVVA 
        60         70         80         90        100
SRIGLSRSAQ PIEPDLDLFD YITALNQQEQ ESDGHPLAAV LIDEAQFLKK 
       110        120        130        140        150
AQVIQCARVV DDLHIPVMAF GLKNDFQNHL FEGSEYLLLY ADKIEEMKTI 
       160        170        180        190        200
CHFCGHKATM ALRYKDGLPV YEGEQVQIGG DEAYYPVCRF HYFHPDQARD

Length:200

Mass (Da):22,552

Last modified:February 8, 2011 - v1

Checksum:ⁱ913DF7EC2CA67DBA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002341 Genomic DNA. Translation: ADQ60678.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013439306.1. NC_014727.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADQ60678; ADQ60678; LDBND_0631.
KEGGⁱ	lde:LDBND_0631.
PATRICⁱ	fig\|767455.3.peg.632.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002341 Genomic DNA. Translation: ADQ60678.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013439306.1. NC_014727.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADQ60678; ADQ60678; LDBND_0631.
KEGGⁱ	lde:LDBND_0631.
PATRICⁱ	fig\|767455.3.peg.632.

Phylogenomic databases

HOGENOMⁱ	HOG000076391.
KEGG Orthology (KO) More...KOⁱ	K00857.
OMAⁱ	KEQFGWI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0659.

Family and domain databases

HAMAPⁱ	MF_00124. Thymidine_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS.
PANTHERⁱ	PTHR11441. PTHR11441. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00265. TK. 1 hit.
PIRSFⁱ	PIRSF035805. TK_cell. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00603. TK_CELLULAR_TYPE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E4SY07_LACDN
Accessionⁱ	E4SY07Primary (citable) accession number: E4SY07
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 8, 2011
	Last sequence update:	February 8, 2011
	Last modified:	July 5, 2017
	This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - E4SY07 (E4SY07_LACDN)

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Thymidine kinase

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Functionⁱ

Catalytic activityⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E4SY07 (E4SY07_LACDN)

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Thymidine kinase

tdk

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ