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E4SY07

- E4SY07_LACDN

UniProt

E4SY07 - E4SY07_LACDN

Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ND02)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Proton acceptorUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi154 – 1541ZincUniRule annotation
    Metal bindingi188 – 1881ZincUniRule annotation
    Metal bindingi191 – 1911ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi93 – 964ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLDEL767455:GHXE-650-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:LDBND_0631Imported
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ND02)Imported
    Taxonomic identifieri767455 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000008717: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiAIPITAD.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4SY07-1 [UniParc]FASTAAdd to Basket

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    MAQFFFEYGA MGSGKTIEIL KVAHNYEIQG RKVALLTSSV DTRSGRGVVA    50
    SRIGLSRSAQ PIEPDLDLFD YITALNQQEQ ESDGHPLAAV LIDEAQFLKK 100
    AQVIQCARVV DDLHIPVMAF GLKNDFQNHL FEGSEYLLLY ADKIEEMKTI 150
    CHFCGHKATM ALRYKDGLPV YEGEQVQIGG DEAYYPVCRF HYFHPDQARD 200
    Length:200
    Mass (Da):22,552
    Last modified:February 8, 2011 - v1
    Checksum:i913DF7EC2CA67DBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002341 Genomic DNA. Translation: ADQ60678.1.
    RefSeqiYP_004033655.1. NC_014727.1.

    Genome annotation databases

    EnsemblBacteriaiADQ60678; ADQ60678; LDBND_0631.
    GeneIDi9990292.
    KEGGilde:LDBND_0631.
    PATRICi43080586. VBILacDel160915_0632.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002341 Genomic DNA. Translation: ADQ60678.1 .
    RefSeqi YP_004033655.1. NC_014727.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ60678 ; ADQ60678 ; LDBND_0631 .
    GeneIDi 9990292.
    KEGGi lde:LDBND_0631.
    PATRICi 43080586. VBILacDel160915_0632.

    Phylogenomic databases

    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi AIPITAD.

    Enzyme and pathway databases

    BioCyci LDEL767455:GHXE-650-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Lactobacillus delbrueckii subsp. bulgaricus strain ND02."
      Chen W., Zhang H., Sun Z., Chen X., Guo Z., Wang J., Wu L., Zhang X., Zhou Z., Sun T., Wang L., Meng H.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ND02Imported.

    Entry informationi

    Entry nameiE4SY07_LACDN
    AccessioniPrimary (citable) accession number: E4SY07
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3