ID   E4SN66_LACAR            Unreviewed;       365 AA.
AC   E4SN66;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Spermidine/putrescine import ATP-binding protein PotA {ECO:0000256|RuleBase:RU364083};
DE            EC=7.6.2.11 {ECO:0000256|RuleBase:RU364083};
GN   Name=potA {ECO:0000256|RuleBase:RU364083};
GN   OrderedLocusNames=LA2_03675 {ECO:0000313|EMBL:ADQ58713.1};
OS   Lactobacillus amylovorus (strain GRL 1112).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=695560 {ECO:0000313|EMBL:ADQ58713.1, ECO:0000313|Proteomes:UP000007033};
RN   [1] {ECO:0000313|EMBL:ADQ58713.1, ECO:0000313|Proteomes:UP000007033}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GRL 1112 {ECO:0000313|EMBL:ADQ58713.1,
RC   ECO:0000313|Proteomes:UP000007033};
RX   PubMed=21131492; DOI=10.1128/JB.01365-10;
RA   Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.;
RT   "Genome sequence of Lactobacillus amylovorus GRL1112.";
RL   J. Bacteriol. 193:789-790(2011).
CC   -!- FUNCTION: Part of the ABC transporter complex PotABCD involved in
CC       spermidine/putrescine import. Responsible for energy coupling to the
CC       transport system. {ECO:0000256|RuleBase:RU364083}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + polyamine-[polyamine-binding protein]Side 1 = ADP
CC         + phosphate + polyamineSide 2 + [polyamine-binding protein]Side 1.;
CC         EC=7.6.2.11; Evidence={ECO:0000256|RuleBase:RU364083};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (PotA),
CC       two transmembrane proteins (PotB and PotC) and a solute-binding protein
CC       (PotD). {ECO:0000256|RuleBase:RU364083}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Spermidine/putrescine importer (TC 3.A.1.11.1) family.
CC       {ECO:0000256|RuleBase:RU364083}.
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DR   EMBL; CP002338; ADQ58713.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4SN66; -.
DR   KEGG; lam:LA2_03675; -.
DR   PATRIC; fig|695560.3.peg.732; -.
DR   HOGENOM; CLU_000604_1_1_9; -.
DR   Proteomes; UP000007033; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0015594; F:ABC-type putrescine transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd03300; ABC_PotA_N; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005893; PotA-like.
DR   InterPro; IPR017879; PotA_ATP-bd.
DR   InterPro; IPR013611; Transp-assoc_OB_typ2.
DR   NCBIfam; TIGR01187; potA; 1.
DR   PANTHER; PTHR42781; SPERMIDINE/PUTRESCINE IMPORT ATP-BINDING PROTEIN POTA; 1.
DR   PANTHER; PTHR42781:SF4; SPERMIDINE_PUTRESCINE IMPORT ATP-BINDING PROTEIN POTA; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08402; TOBE_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; MOP-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364083};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU364083};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364083};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU364083};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU364083};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU364083}.
FT   DOMAIN          4..235
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   365 AA;  41108 MW;  34ED46349EF16FA0 CRC64;
     MDIIKLKHIT KQYDDGFVAL KDINLTIESG KFYSLLGPSG SGKSTILRII AGFTQPTDGK
     VYFDGKDITN LDAAKRHINT VFQNYALFPH LNVFENVAFG LKIKKKPMNE IKPAVKDALH
     MVQLDGYANR EISELSGGQQ QRVAIARAIV NEPKVLLLDE SLSALDKRLR KDMQFELRAI
     QKKLGITFIF VTHDQEEALS MSDEIFVLND GEIQQSGSPV AIYDEPVNDF VARFIGDSNI
     LSGRMIKDYE VEFANNKFKC ADGGIKPNEK VEVVIRPEDL DIVDPEKGKI VVTAQTQLFL
     GDHFEIKAID ADENEWLIHS TNGVKLGQRI GLFFDPEDIH VMRLNESQAD FDARIEKYEG
     DENED
//