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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Lactobacillus amylovorus (strain GRL 1112)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (LA2_04990)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei61SubstrateUniRule annotation1
Active sitei88Proton donor/acceptorUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:LA2_01765Imported
OrganismiLactobacillus amylovorus (strain GRL 1112)Imported
Taxonomic identifieri695560 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000007033 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE4SL10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotation8
Regioni21 – 22Substrate bindingUniRule annotation2
Regioni88 – 91Substrate bindingUniRule annotation4
Regioni115 – 116Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000221682.
KOiK01834.
OMAiNLHAVGP.
OrthoDBiPOG091H03E2.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiView protein in InterPro
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiView protein in Pfam
PF00300. His_Phos_1. 1 hit.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

E4SL10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLVLVRHG ESVANAANVY TGWNDVPLTH KGEEQAKQAG ELINTISDFA
60 70 80 90 100
PTHIHTSVLS RAITTANIVA DTCNLLWLPI TKTWRLNERH YGALRGLNKD
110 120 130 140 150
ISRKVFGVEQ VLLWRRGFDS VPPAQGSPMI DRRYKLCDQH LMPRAESLHQ
160 170 180 190 200
TQKRLMPYYY DHIASRLLNG EDQLIVAHGS SLRALIKKLE NINDHDIVNL
210 220
EVPNAEPIVY TMDDQLNIVD KKILH
Length:225
Mass (Da):25,541
Last modified:February 8, 2011 - v1
Checksum:iBECF8D8C57A0F55A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002338 Genomic DNA. Translation: ADQ58346.1.
RefSeqiWP_013437162.1. NC_014724.1.

Genome annotation databases

EnsemblBacteriaiADQ58346; ADQ58346; LA2_01765.
GeneIDi31801451.
KEGGilam:LA2_01765.
PATRICifig|695560.3.peg.350.

Similar proteinsi

Entry informationi

Entry nameiE4SL10_LACAR
AccessioniPrimary (citable) accession number: E4SL10
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 27, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported