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E4SKB4

- E4SKB4_LACAR

UniProt

E4SKB4 - E4SKB4_LACAR

Protein

Ribonuclease 3

Gene

rnc

Organism
Lactobacillus amylovorus (strain GRL 1112)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

    Cofactori

    Mg2+.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi49 – 491MagnesiumUniRule annotation
    Active sitei53 – 531UniRule annotation
    Metal bindingi122 – 1221MagnesiumUniRule annotation
    Metal bindingi125 – 1251MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLAMY695560:GI0Z-1445-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotationImported
    Ordered Locus Names:LA2_07330Imported
    OrganismiLactobacillus amylovorus (strain GRL 1112)Imported
    Taxonomic identifieri695560 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000007033: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 136130RNase IIIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
    Contains 1 RNase III domain.UniRule annotation
    Contains DRBM (double-stranded RNA-binding) domain.SAAS annotation
    Contains RNase III domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000246808.
    KOiK03685.
    OMAiYGFQEAR.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4SKB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSTKFLKKL KDEYNVKFNN EKLLEEAFTH SSYSNEHPDA GIRDYEKLEF    50
    LGDAVLELAV SNYLYRHYPK LNEGELTRLR SNIVRTEGFS EFAIECGFQK 100
    EIHLGNGEEK AGARNRKTLL EDVFEAFNGA LYLDQGMPAV EHFLHLTVYP 150
    LIDKGEFDDS RDYKTDLQEL LQQNGPVNIE YSVISESQLP SHFEVELKIN 200
    DEAKTRGEGH NKKAAEQQAA KAALKELE 228
    Length:228
    Mass (Da):26,091
    Last modified:February 8, 2011 - v1
    Checksum:iB0FC04BB6088C991
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002338 Genomic DNA. Translation: ADQ59387.1.
    RefSeqiYP_004032182.1. NC_014724.1.

    Genome annotation databases

    EnsemblBacteriaiADQ59387; ADQ59387; LA2_07330.
    GeneIDi10023430.
    KEGGilam:LA2_07330.
    PATRICi43077910. VBILacAmy150400_1445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002338 Genomic DNA. Translation: ADQ59387.1 .
    RefSeqi YP_004032182.1. NC_014724.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ59387 ; ADQ59387 ; LA2_07330 .
    GeneIDi 10023430.
    KEGGi lam:LA2_07330.
    PATRICi 43077910. VBILacAmy150400_1445.

    Phylogenomic databases

    HOGENOMi HOG000246808.
    KOi K03685.
    OMAi YGFQEAR.

    Enzyme and pathway databases

    BioCyci LAMY695560:GI0Z-1445-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Lactobacillus amylovorus GRL1112."
      Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
      J. Bacteriol. 193:789-790(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GRL 1112Imported.

    Entry informationi

    Entry nameiE4SKB4_LACAR
    AccessioniPrimary (citable) accession number: E4SKB4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3