Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E4SKB4 (E4SKB4_LACAR) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3 HAMAP-Rule MF_00104

EC=3.1.26.3 HAMAP-Rule MF_00104
Alternative name(s):
Ribonuclease III HAMAP-Rule MF_00104
Gene names
Name:rnc HAMAP-Rule MF_00104 EMBL ADQ59387.1
Ordered Locus Names:LA2_07330 EMBL ADQ59387.1
OrganismLactobacillus amylovorus (strain GRL 1112) [Complete proteome] [HAMAP] EMBL ADQ59387.1
Taxonomic identifier695560 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104 SAAS SAAS011907

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104 SAAS SAAS011907

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104 SAAS SAAS011907

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104 SAAS SAAS011907

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104 SAAS SAAS011907.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain. HAMAP-Rule MF_00104

Contains 1 RNase III domain. HAMAP-Rule MF_00104

Contains DRBM (double-stranded RNA-binding) domain. SAAS SAAS011907

Contains RNase III domain. SAAS SAAS011907

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain7 – 136130RNase III By similarity HAMAP-Rule MF_00104

Sites

Active site531 By similarity HAMAP-Rule MF_00104
Metal binding491Magnesium By similarity HAMAP-Rule MF_00104
Metal binding1221Magnesium By similarity HAMAP-Rule MF_00104
Metal binding1251Magnesium By similarity HAMAP-Rule MF_00104

Sequences

Sequence LengthMass (Da)Tools
E4SKB4 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: B0FC04BB6088C991

FASTA22826,091
        10         20         30         40         50         60 
MVSTKFLKKL KDEYNVKFNN EKLLEEAFTH SSYSNEHPDA GIRDYEKLEF LGDAVLELAV 

        70         80         90        100        110        120 
SNYLYRHYPK LNEGELTRLR SNIVRTEGFS EFAIECGFQK EIHLGNGEEK AGARNRKTLL 

       130        140        150        160        170        180 
EDVFEAFNGA LYLDQGMPAV EHFLHLTVYP LIDKGEFDDS RDYKTDLQEL LQQNGPVNIE 

       190        200        210        220 
YSVISESQLP SHFEVELKIN DEAKTRGEGH NKKAAEQQAA KAALKELE 

« Hide

References

[1]"Genome sequence of Lactobacillus amylovorus GRL1112."
Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
J. Bacteriol. 193:789-790(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GRL 1112 EMBL ADQ59387.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002338 Genomic DNA. Translation: ADQ59387.1.
RefSeqYP_004032182.1. NC_014724.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ59387; ADQ59387; LA2_07330.
GeneID10023430.
KEGGlam:LA2_07330.
PATRIC43077910. VBILacAmy150400_1445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000246808.
KOK03685.
OMALTHKSCK.

Enzyme and pathway databases

BioCycLAMY695560:GI0Z-1445-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4SKB4_LACAR
AccessionPrimary (citable) accession number: E4SKB4
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)