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E4SKB4

- E4SKB4_LACAR

UniProt

E4SKB4 - E4SKB4_LACAR

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Protein
Ribonuclease 3
Gene
rnc, LA2_07330
Organism
Lactobacillus amylovorus (strain GRL 1112)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity.SAAS annotations
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotations

Cofactori

Mg2+ By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi49 – 491Magnesium By similarityUniRule annotation
Active sitei53 – 531 By similarityUniRule annotation
Metal bindingi122 – 1221Magnesium By similarityUniRule annotation
Metal bindingi125 – 1251Magnesium By similarityUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. rRNA binding Source: UniProtKB-KW
  3. ribonuclease III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotations, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processingUniRule annotationSAAS annotations, rRNA processingUniRule annotationSAAS annotations, tRNA processingUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, RNA-binding, rRNA-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLAMY695560:GI0Z-1445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease III
Gene namesi
Name:rncUniRule annotationImported
Ordered Locus Names:LA2_07330Imported
OrganismiLactobacillus amylovorus (strain GRL 1112)Imported
Taxonomic identifieri695560 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000007033: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 136130RNase III By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.UniRule annotation
Contains DRBM (double-stranded RNA-binding) domain.SAAS annotations
Contains RNase III domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000246808.
KOiK03685.
OMAiYGFQEAR.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4SKB4-1 [UniParc]FASTAAdd to Basket

« Hide

MVSTKFLKKL KDEYNVKFNN EKLLEEAFTH SSYSNEHPDA GIRDYEKLEF    50
LGDAVLELAV SNYLYRHYPK LNEGELTRLR SNIVRTEGFS EFAIECGFQK 100
EIHLGNGEEK AGARNRKTLL EDVFEAFNGA LYLDQGMPAV EHFLHLTVYP 150
LIDKGEFDDS RDYKTDLQEL LQQNGPVNIE YSVISESQLP SHFEVELKIN 200
DEAKTRGEGH NKKAAEQQAA KAALKELE 228
Length:228
Mass (Da):26,091
Last modified:February 8, 2011 - v1
Checksum:iB0FC04BB6088C991
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002338 Genomic DNA. Translation: ADQ59387.1.
RefSeqiYP_004032182.1. NC_014724.1.

Genome annotation databases

EnsemblBacteriaiADQ59387; ADQ59387; LA2_07330.
GeneIDi10023430.
KEGGilam:LA2_07330.
PATRICi43077910. VBILacAmy150400_1445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002338 Genomic DNA. Translation: ADQ59387.1 .
RefSeqi YP_004032182.1. NC_014724.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ59387 ; ADQ59387 ; LA2_07330 .
GeneIDi 10023430.
KEGGi lam:LA2_07330.
PATRICi 43077910. VBILacAmy150400_1445.

Phylogenomic databases

HOGENOMi HOG000246808.
KOi K03685.
OMAi YGFQEAR.

Enzyme and pathway databases

BioCyci LAMY695560:GI0Z-1445-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Lactobacillus amylovorus GRL1112."
    Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.
    J. Bacteriol. 193:789-790(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GRL 1112Imported.

Entry informationi

Entry nameiE4SKB4_LACAR
AccessioniPrimary (citable) accession number: E4SKB4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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