E4SEY5 (E4SEY5_CALK2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartokinase RuleBase RU003448
EC=2.7.2.4 RuleBase RU003448

Gene names

Ordered Locus Names:

Calkro_0731

Organism

Caldicellulosiruptor kronotskyensis (strain DSM 18902 / VKM B-2412 / 2002) [Complete proteome] [HAMAP] EMBL ADQ45622.1

Taxonomic identifier

632348 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor › Caldicellulosiruptor kronotskyensis

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. RuleBase RU004249 Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. RuleBase RU004249 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. RuleBase RU004249
Sequence similarities	Belongs to the aspartokinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004249
Molecular function	Kinase RuleBase RU003448 EMBL ADQ45622.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: UniProtKB-UniPathway threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E4SEY5 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 02D82E92E2097E7B	FASTA	409	44,589
	10 20 30 40 50 60 MGIVVQKYGG TSVADKERIF RAARRAISEY EKGNKVVVVV SAQGDTTDEL IEKAKEINEN 70 80 90 100 110 120 PSKREMDMLL STGEQISIAL MAMAIEKLGY PVISLTGWQA GIKTDSHYSN ARIIEIDSER 130 140 150 160 170 180 LQRELDKRNI VVVAGFQGIN KYDDITTLGR GGSDTTAVAL AAALKADKCE IYTDVDGVYT 190 200 210 220 230 240 ADPRIVPNAS KLKEISYDEM LELATLGAKV LHNRSVELAK KYNIPLVVRS SFNDNEGTIV 250 260 270 280 290 300 KEVNSVEKLL VSGVACDKDI ARVAVIGVEN VPGKAFQIFS LLAKENINVD IILQSIGREK 310 320 330 340 350 360 TKDISFTVSK SNLKQTLDVL TKNLHIIGAK DITYADNVAK VSIVGAGMVN NPGVAAMMFE 370 380 390 400 ALYDAGINIE MISTSEIKIS VLIDEKDAEK AVRAIHDKFK LHLLNSNGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence of Caldicellulosiruptor kronotskyensis 2002." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Blumer-Schuette S.E., Kelly R.M., Woyke T. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 2002.
[2]	"Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensensis, and Caldicellulosiruptor lactoaceticus." Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M. J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 18902 / VKM B-2412 / 2002.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002330 Genomic DNA. Translation: ADQ45622.1.
RefSeq	YP_004023441.1. NC_014720.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADQ45622; ADQ45622; Calkro_0731.
GeneID	9980678.
KEGG	ckn:Calkro_0731.
PATRIC	42808329. VBICalKro6863_0776.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000293093.
KO	K00928.
Enzyme and pathway databases
BioCyc	CKRO632348:GI5C-750-MONOMER.
UniPathway	UPA00034; UER00015. UPA00050; UER00461. UPA00051; UER00462.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
InterPro	IPR002912. ACT_dom. IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. PF01842. ACT. 1 hit. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00656. asp_kin_monofn. 1 hit. TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E4SEY5_CALK2

Accession

Primary (citable) accession number: E4SEY5

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)