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E4S4W9

- E4S4W9_CALKI

UniProt

E4S4W9 - E4S4W9_CALKI

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Protein

Xylose isomerase

Gene

xylA

Organism
Caldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001UniRule annotation
Active sitei103 – 1031UniRule annotation
Metal bindingi231 – 2311Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 2UniRule annotation
Metal bindingi270 – 2701Magnesium 2UniRule annotation
Metal bindingi295 – 2951Magnesium 1UniRule annotation
Metal bindingi306 – 3061Magnesium 2UniRule annotation
Metal bindingi308 – 3081Magnesium 2UniRule annotation
Metal bindingi338 – 3381Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCKRI632335:GI3P-2048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Calkr_1997Imported
OrganismiCaldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B)Imported
Taxonomic identifieri632335 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000009256: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE4S4W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4S4W9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYFKDIPEV KYEGPQSDNP FAFKYYNPDE VIDGKPLKDH LRFAIAYWHT
60 70 80 90 100
FCATGSDPFG QPTINRPWDR FSNPMDNAKA RVEAAFEFFE KLNVPFFCFH
110 120 130 140 150
DRDIAPEGEN LRETNKNLDE IVSMIKEYLK TSKTRVLWGT ANLFSHPRYV
160 170 180 190 200
HGAATSCNAD VFAYAAAQVK KALEVTKELG GENYVFWGGR EGYETLLNTD
210 220 230 240 250
MELELDNLAR FLHMAVDYAK EIGFDGQFLI EPKPKEPTKH QYDFDAAHVY
260 270 280 290 300
GFLKKYDLDK YFKLNIEVNH ATLAGHDFHH ELRFARINNM LGSIDANMGD
310 320 330 340 350
LLLGWDTDQF PTDVRLTTLA MYEVIKAGGF DKGGLNFDAK VRRGSFELED
360 370 380 390 400
LVIGHIAGMD AFAKGFKIAY KLVKDGVFDK FIEERYRSYK EGIGAKIVSG
410 420 430
QADFKTLEEY ALNLSKIENK SGKQELLEMI LNKYMFSE
Length:438
Mass (Da):50,214
Last modified:February 8, 2011 - v1
Checksum:i5DD57730E80210EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002326 Genomic DNA. Translation: ADQ41469.1.
RefSeqiYP_004027082.1. NC_014721.1.

Genome annotation databases

EnsemblBacteriaiADQ41469; ADQ41469; Calkr_1997.
GeneIDi9984678.
KEGGicki:Calkr_1997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002326 Genomic DNA. Translation: ADQ41469.1 .
RefSeqi YP_004027082.1. NC_014721.1.

3D structure databases

ProteinModelPortali E4S4W9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ41469 ; ADQ41469 ; Calkr_1997 .
GeneIDi 9984678.
KEGGi cki:Calkr_1997.

Phylogenomic databases

HOGENOMi HOG000252293.
KOi K01805.

Enzyme and pathway databases

BioCyci CKRI632335:GI3P-2048-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Caldicellulosiruptor kristjanssonii 177R1B."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Blumer-Schuette S.E., Kelly R.M., Woyke T.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 177R1B.
  2. "Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus."
    Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M.
    J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700853 / DSM 12137 / I77R1BImported.

Entry informationi

Entry nameiE4S4W9_CALKI
AccessioniPrimary (citable) accession number: E4S4W9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3