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E4S4W9

- E4S4W9_CALKI

UniProt

E4S4W9 - E4S4W9_CALKI

Protein

Xylose isomerase

Gene

xylA

Organism
Caldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001UniRule annotation
    Active sitei103 – 1031UniRule annotation
    Metal bindingi231 – 2311Magnesium 1UniRule annotation
    Metal bindingi267 – 2671Magnesium 1UniRule annotation
    Metal bindingi267 – 2671Magnesium 2UniRule annotation
    Metal bindingi270 – 2701Magnesium 2UniRule annotation
    Metal bindingi295 – 2951Magnesium 1UniRule annotation
    Metal bindingi306 – 3061Magnesium 2UniRule annotation
    Metal bindingi308 – 3081Magnesium 2UniRule annotation
    Metal bindingi338 – 3381Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCKRI632335:GI3P-2048-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    Ordered Locus Names:Calkr_1997Imported
    OrganismiCaldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B)Imported
    Taxonomic identifieri632335 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000009256: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE4S4W9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252293.
    KOiK01805.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4S4W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYFKDIPEV KYEGPQSDNP FAFKYYNPDE VIDGKPLKDH LRFAIAYWHT    50
    FCATGSDPFG QPTINRPWDR FSNPMDNAKA RVEAAFEFFE KLNVPFFCFH 100
    DRDIAPEGEN LRETNKNLDE IVSMIKEYLK TSKTRVLWGT ANLFSHPRYV 150
    HGAATSCNAD VFAYAAAQVK KALEVTKELG GENYVFWGGR EGYETLLNTD 200
    MELELDNLAR FLHMAVDYAK EIGFDGQFLI EPKPKEPTKH QYDFDAAHVY 250
    GFLKKYDLDK YFKLNIEVNH ATLAGHDFHH ELRFARINNM LGSIDANMGD 300
    LLLGWDTDQF PTDVRLTTLA MYEVIKAGGF DKGGLNFDAK VRRGSFELED 350
    LVIGHIAGMD AFAKGFKIAY KLVKDGVFDK FIEERYRSYK EGIGAKIVSG 400
    QADFKTLEEY ALNLSKIENK SGKQELLEMI LNKYMFSE 438
    Length:438
    Mass (Da):50,214
    Last modified:February 8, 2011 - v1
    Checksum:i5DD57730E80210EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002326 Genomic DNA. Translation: ADQ41469.1.
    RefSeqiYP_004027082.1. NC_014721.1.

    Genome annotation databases

    EnsemblBacteriaiADQ41469; ADQ41469; Calkr_1997.
    GeneIDi9984678.
    KEGGicki:Calkr_1997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002326 Genomic DNA. Translation: ADQ41469.1 .
    RefSeqi YP_004027082.1. NC_014721.1.

    3D structure databases

    ProteinModelPortali E4S4W9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ41469 ; ADQ41469 ; Calkr_1997 .
    GeneIDi 9984678.
    KEGGi cki:Calkr_1997.

    Phylogenomic databases

    HOGENOMi HOG000252293.
    KOi K01805.

    Enzyme and pathway databases

    BioCyci CKRI632335:GI3P-2048-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Caldicellulosiruptor kristjanssonii 177R1B."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Blumer-Schuette S.E., Kelly R.M., Woyke T.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 177R1B.
    2. "Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus."
      Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M.
      J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700853 / DSM 12137 / I77R1BImported.

    Entry informationi

    Entry nameiE4S4W9_CALKI
    AccessioniPrimary (citable) accession number: E4S4W9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3