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Protein

Xylose isomerase

Gene

xylA

Organism
Caldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001UniRule annotation
Active sitei103 – 1031UniRule annotation
Metal bindingi231 – 2311Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 2UniRule annotation
Metal bindingi270 – 2701Magnesium 2UniRule annotation
Metal bindingi295 – 2951Magnesium 1UniRule annotation
Metal bindingi306 – 3061Magnesium 2UniRule annotation
Metal bindingi308 – 3081Magnesium 2UniRule annotation
Metal bindingi338 – 3381Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCKRI632335:GI3P-2048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Calkr_1997Imported
OrganismiCaldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B)Imported
Taxonomic identifieri632335 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000009256 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi632335.Calkr_1997.

Structurei

3D structure databases

ProteinModelPortaliE4S4W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4S4W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYFKDIPEV KYEGPQSDNP FAFKYYNPDE VIDGKPLKDH LRFAIAYWHT
60 70 80 90 100
FCATGSDPFG QPTINRPWDR FSNPMDNAKA RVEAAFEFFE KLNVPFFCFH
110 120 130 140 150
DRDIAPEGEN LRETNKNLDE IVSMIKEYLK TSKTRVLWGT ANLFSHPRYV
160 170 180 190 200
HGAATSCNAD VFAYAAAQVK KALEVTKELG GENYVFWGGR EGYETLLNTD
210 220 230 240 250
MELELDNLAR FLHMAVDYAK EIGFDGQFLI EPKPKEPTKH QYDFDAAHVY
260 270 280 290 300
GFLKKYDLDK YFKLNIEVNH ATLAGHDFHH ELRFARINNM LGSIDANMGD
310 320 330 340 350
LLLGWDTDQF PTDVRLTTLA MYEVIKAGGF DKGGLNFDAK VRRGSFELED
360 370 380 390 400
LVIGHIAGMD AFAKGFKIAY KLVKDGVFDK FIEERYRSYK EGIGAKIVSG
410 420 430
QADFKTLEEY ALNLSKIENK SGKQELLEMI LNKYMFSE
Length:438
Mass (Da):50,214
Last modified:February 8, 2011 - v1
Checksum:i5DD57730E80210EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002326 Genomic DNA. Translation: ADQ41469.1.
RefSeqiWP_013433194.1. NC_014721.1.

Genome annotation databases

EnsemblBacteriaiADQ41469; ADQ41469; Calkr_1997.
KEGGicki:Calkr_1997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002326 Genomic DNA. Translation: ADQ41469.1.
RefSeqiWP_013433194.1. NC_014721.1.

3D structure databases

ProteinModelPortaliE4S4W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi632335.Calkr_1997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADQ41469; ADQ41469; Calkr_1997.
KEGGicki:Calkr_1997.

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Enzyme and pathway databases

BioCyciCKRI632335:GI3P-2048-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Caldicellulosiruptor kristjanssonii 177R1B."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Blumer-Schuette S.E., Kelly R.M., Woyke T.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 177R1B.
  2. "Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus."
    Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M.
    J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700853 / DSM 12137 / I77R1BImported.

Entry informationi

Entry nameiE4S4W9_CALKI
AccessioniPrimary (citable) accession number: E4S4W9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 22, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.