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E4RZ68

- E4RZ68_LEAB4

UniProt

E4RZ68 - E4RZ68_LEAB4

Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

Lbys_3538

Organism
Leadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation.SAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBYS649349:GHFA-3591-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
    Gene namesi
    Ordered Locus Names:Lbys_3538Imported
    OrganismiLeadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)Imported
    Taxonomic identifieri649349 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeLeadbetterella
    ProteomesiUP000007435: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000011592.
    KOiK01921.
    OMAiQGLLEWY.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4RZ68-1 [UniParc]FASTAAdd to Basket

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    MDKKIKVGIF FGGQSREREI SFLGGRTAYE HLDKRFFEPV LIFVDSLGNF    50
    IHVEPSILNE ADIRSFYPSK NQNNGYKVYI ESLGPLKVSQ LYKLIYKIGS 100
    QVKIEELKSY MDFAFVVMHG PSAEDGSIQG LLEWLNIPYL GPGILGSAVG 150
    INKPFQNKLM AYATGQEKKY LTISKREWNT SDRSKLFSSV IAKLGFPFVV 200
    KAPHQGSSIG VAIVRKRSLE EFSKAMSQCF FETFITKKEW DKLSPRRKKN 250
    VMEKMSNLDE GIGFPVVLDG EQIYHPATLL KKLDEYLTQH EVAQLNSVNG 300
    EDYVLIEEFI SGQEFSCGVI QDDEGRVLPL PPAEVYGETA TFDFKAKYKS 350
    TVSKKRIPVK TSDANLEKIH EDVLKAFEAT GMSVICRIDG FITEDDVVVL 400
    HDPNTLPGMS PSSFIFKQMA EVGFNITNSL TYFIRQSLIE RIRSGKNQFE 450
    VQQLLNHLST QIKNAPARKR LAVLFGENEK EFILAKKVYN ELCGSEEYEP 500
    VPVCAALNGS RYIIPLNLMY KPDINEFGTA IATPKHPFIQ KNIELVKQVR 550
    AFYAGEVDFS VRKVSEQDYN QIFKHTYDCL TGELH 585
    Length:585
    Mass (Da):66,307
    Last modified:February 8, 2011 - v1
    Checksum:iCC0EBA8B0E9620C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002305 Genomic DNA. Translation: ADQ19186.1.
    RefSeqiWP_013410207.1. NC_014655.1.
    YP_003999539.1. NC_014655.1.

    Genome annotation databases

    EnsemblBacteriaiADQ19186; ADQ19186; Lbys_3538.
    GeneIDi9957424.
    KEGGilby:Lbys_3538.
    PATRICi42657207. VBILeaBys116579_3633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002305 Genomic DNA. Translation: ADQ19186.1 .
    RefSeqi WP_013410207.1. NC_014655.1.
    YP_003999539.1. NC_014655.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ19186 ; ADQ19186 ; Lbys_3538 .
    GeneIDi 9957424.
    KEGGi lby:Lbys_3538.
    PATRICi 42657207. VBILeaBys116579_3633.

    Phylogenomic databases

    HOGENOMi HOG000011592.
    KOi K01921.
    OMAi QGLLEWY.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci LBYS649349:GHFA-3591-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17132.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17132 / KACC 11308 / 4M15Imported.

    Entry informationi

    Entry nameiE4RZ68_LEAB4
    AccessioniPrimary (citable) accession number: E4RZ68
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3