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E4RZ68

- E4RZ68_LEAB4

UniProt

E4RZ68 - E4RZ68_LEAB4

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Protein
Submitted name: D-alanine--D-alanine ligase
Gene
Lbys_3538
Organism
Leadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.SAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.SAAS annotations

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotations, Peptidoglycan synthesisSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, MagnesiumSAAS annotations, ManganeseSAAS annotations, Metal-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBYS649349:GHFA-3591-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
Gene namesi
Ordered Locus Names:Lbys_3538Imported
OrganismiLeadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)Imported
Taxonomic identifieri649349 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeLeadbetterella
ProteomesiUP000007435: Chromosome

Subcellular locationi

Cytoplasm By similarity SAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiQGLLEWY.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4RZ68-1 [UniParc]FASTAAdd to Basket

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MDKKIKVGIF FGGQSREREI SFLGGRTAYE HLDKRFFEPV LIFVDSLGNF    50
IHVEPSILNE ADIRSFYPSK NQNNGYKVYI ESLGPLKVSQ LYKLIYKIGS 100
QVKIEELKSY MDFAFVVMHG PSAEDGSIQG LLEWLNIPYL GPGILGSAVG 150
INKPFQNKLM AYATGQEKKY LTISKREWNT SDRSKLFSSV IAKLGFPFVV 200
KAPHQGSSIG VAIVRKRSLE EFSKAMSQCF FETFITKKEW DKLSPRRKKN 250
VMEKMSNLDE GIGFPVVLDG EQIYHPATLL KKLDEYLTQH EVAQLNSVNG 300
EDYVLIEEFI SGQEFSCGVI QDDEGRVLPL PPAEVYGETA TFDFKAKYKS 350
TVSKKRIPVK TSDANLEKIH EDVLKAFEAT GMSVICRIDG FITEDDVVVL 400
HDPNTLPGMS PSSFIFKQMA EVGFNITNSL TYFIRQSLIE RIRSGKNQFE 450
VQQLLNHLST QIKNAPARKR LAVLFGENEK EFILAKKVYN ELCGSEEYEP 500
VPVCAALNGS RYIIPLNLMY KPDINEFGTA IATPKHPFIQ KNIELVKQVR 550
AFYAGEVDFS VRKVSEQDYN QIFKHTYDCL TGELH 585
Length:585
Mass (Da):66,307
Last modified:February 8, 2011 - v1
Checksum:iCC0EBA8B0E9620C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002305 Genomic DNA. Translation: ADQ19186.1.
RefSeqiWP_013410207.1. NC_014655.1.
YP_003999539.1. NC_014655.1.

Genome annotation databases

EnsemblBacteriaiADQ19186; ADQ19186; Lbys_3538.
GeneIDi9957424.
KEGGilby:Lbys_3538.
PATRICi42657207. VBILeaBys116579_3633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002305 Genomic DNA. Translation: ADQ19186.1 .
RefSeqi WP_013410207.1. NC_014655.1.
YP_003999539.1. NC_014655.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ19186 ; ADQ19186 ; Lbys_3538 .
GeneIDi 9957424.
KEGGi lby:Lbys_3538.
PATRICi 42657207. VBILeaBys116579_3633.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi QGLLEWY.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LBYS649349:GHFA-3591-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17132.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17132 / KACC 11308 / 4M15.

Entry informationi

Entry nameiE4RZ68_LEAB4
AccessioniPrimary (citable) accession number: E4RZ68
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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