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Protein

D-alanine--D-alanine ligase

Gene

Lbys_3538

Organism
Leadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathway:ipeptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBYS649349:GHFA-3591-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Lbys_3538Imported
OrganismiLeadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)Imported
Taxonomic identifieri649349 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeLeadbetterella
ProteomesiUP000007435 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi649349.Lbys_3538.

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiFKQMAEI.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4RZ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKIKVGIF FGGQSREREI SFLGGRTAYE HLDKRFFEPV LIFVDSLGNF
60 70 80 90 100
IHVEPSILNE ADIRSFYPSK NQNNGYKVYI ESLGPLKVSQ LYKLIYKIGS
110 120 130 140 150
QVKIEELKSY MDFAFVVMHG PSAEDGSIQG LLEWLNIPYL GPGILGSAVG
160 170 180 190 200
INKPFQNKLM AYATGQEKKY LTISKREWNT SDRSKLFSSV IAKLGFPFVV
210 220 230 240 250
KAPHQGSSIG VAIVRKRSLE EFSKAMSQCF FETFITKKEW DKLSPRRKKN
260 270 280 290 300
VMEKMSNLDE GIGFPVVLDG EQIYHPATLL KKLDEYLTQH EVAQLNSVNG
310 320 330 340 350
EDYVLIEEFI SGQEFSCGVI QDDEGRVLPL PPAEVYGETA TFDFKAKYKS
360 370 380 390 400
TVSKKRIPVK TSDANLEKIH EDVLKAFEAT GMSVICRIDG FITEDDVVVL
410 420 430 440 450
HDPNTLPGMS PSSFIFKQMA EVGFNITNSL TYFIRQSLIE RIRSGKNQFE
460 470 480 490 500
VQQLLNHLST QIKNAPARKR LAVLFGENEK EFILAKKVYN ELCGSEEYEP
510 520 530 540 550
VPVCAALNGS RYIIPLNLMY KPDINEFGTA IATPKHPFIQ KNIELVKQVR
560 570 580
AFYAGEVDFS VRKVSEQDYN QIFKHTYDCL TGELH
Length:585
Mass (Da):66,307
Last modified:February 8, 2011 - v1
Checksum:iCC0EBA8B0E9620C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002305 Genomic DNA. Translation: ADQ19186.1.

Genome annotation databases

EnsemblBacteriaiADQ19186; ADQ19186; Lbys_3538.
KEGGilby:Lbys_3538.
PATRICi42657207. VBILeaBys116579_3633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002305 Genomic DNA. Translation: ADQ19186.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi649349.Lbys_3538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADQ19186; ADQ19186; Lbys_3538.
KEGGilby:Lbys_3538.
PATRICi42657207. VBILeaBys116579_3633.

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiFKQMAEI.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciLBYS649349:GHFA-3591-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17132.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17132 / KACC 11308 / 4M15Imported.

Entry informationi

Entry nameiE4RZ68_LEAB4
AccessioniPrimary (citable) accession number: E4RZ68
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 22, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.