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E4RZ68

- E4RZ68_LEAB4

UniProt

E4RZ68 - E4RZ68_LEAB4

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Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

Lbys_3538

Organism
Leadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBYS649349:GHFA-3591-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
Gene namesi
Ordered Locus Names:Lbys_3538Imported
OrganismiLeadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15)Imported
Taxonomic identifieri649349 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeLeadbetterella
ProteomesiUP000007435: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiQGLLEWY.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4RZ68-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKKIKVGIF FGGQSREREI SFLGGRTAYE HLDKRFFEPV LIFVDSLGNF
60 70 80 90 100
IHVEPSILNE ADIRSFYPSK NQNNGYKVYI ESLGPLKVSQ LYKLIYKIGS
110 120 130 140 150
QVKIEELKSY MDFAFVVMHG PSAEDGSIQG LLEWLNIPYL GPGILGSAVG
160 170 180 190 200
INKPFQNKLM AYATGQEKKY LTISKREWNT SDRSKLFSSV IAKLGFPFVV
210 220 230 240 250
KAPHQGSSIG VAIVRKRSLE EFSKAMSQCF FETFITKKEW DKLSPRRKKN
260 270 280 290 300
VMEKMSNLDE GIGFPVVLDG EQIYHPATLL KKLDEYLTQH EVAQLNSVNG
310 320 330 340 350
EDYVLIEEFI SGQEFSCGVI QDDEGRVLPL PPAEVYGETA TFDFKAKYKS
360 370 380 390 400
TVSKKRIPVK TSDANLEKIH EDVLKAFEAT GMSVICRIDG FITEDDVVVL
410 420 430 440 450
HDPNTLPGMS PSSFIFKQMA EVGFNITNSL TYFIRQSLIE RIRSGKNQFE
460 470 480 490 500
VQQLLNHLST QIKNAPARKR LAVLFGENEK EFILAKKVYN ELCGSEEYEP
510 520 530 540 550
VPVCAALNGS RYIIPLNLMY KPDINEFGTA IATPKHPFIQ KNIELVKQVR
560 570 580
AFYAGEVDFS VRKVSEQDYN QIFKHTYDCL TGELH
Length:585
Mass (Da):66,307
Last modified:February 8, 2011 - v1
Checksum:iCC0EBA8B0E9620C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002305 Genomic DNA. Translation: ADQ19186.1.
RefSeqiYP_003999539.1. NC_014655.1.

Genome annotation databases

EnsemblBacteriaiADQ19186; ADQ19186; Lbys_3538.
GeneIDi9957424.
KEGGilby:Lbys_3538.
PATRICi42657207. VBILeaBys116579_3633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002305 Genomic DNA. Translation: ADQ19186.1 .
RefSeqi YP_003999539.1. NC_014655.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ19186 ; ADQ19186 ; Lbys_3538 .
GeneIDi 9957424.
KEGGi lby:Lbys_3538.
PATRICi 42657207. VBILeaBys116579_3633.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi QGLLEWY.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LBYS649349:GHFA-3591-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17132.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17132 / KACC 11308 / 4M15Imported.

Entry informationi

Entry nameiE4RZ68_LEAB4
AccessioniPrimary (citable) accession number: E4RZ68
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3