UniProtKB - E4RPE3 (E4RPE3_HALHG)
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Protein
Alanine racemase
Gene
Halsa_0353
Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Functioni
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation
Catalytic activityi
L-alanine = D-alanine.UniRule annotationSAAS annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotationSAAS annotation
: D-alanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Alanine racemase (Halsa_0353)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 43 | Proton acceptor; specific for D-alanineUniRule annotation | 1 | |
Binding sitei | 141 | SubstrateUniRule annotation | 1 | |
Active sitei | 270 | Proton acceptor; specific for L-alanineUniRule annotation | 1 | |
Binding sitei | 318 | Substrate; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- alanine racemase activity Source: UniProtKB-UniRule
- pyridoxal phosphate binding Source: UniProtKB-UniRule
GO - Biological processi
- D-alanine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | IsomeraseUniRule annotationSAAS annotationImported |
Ligand | Pyridoxal phosphateUniRule annotationSAAS annotation |
Enzyme and pathway databases
BioCyci | HHYD656519:G1GOZ-361-MONOMER. |
UniPathwayi | UPA00042; UER00497. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:Halsa_0353Imported |
Organismi | Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported |
Taxonomic identifieri | 656519 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Halanaerobiales › Halanaerobiaceae › Halanaerobium |
Proteomesi |
|
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 43 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 249 – 377 | Ala_racemase_CInterPro annotationAdd BLAST | 129 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105CJ4. Bacteria. COG0787. LUCA. |
KOi | K01775. |
OMAi | WRGPILL. |
OrthoDBi | POG091H022F. |
Family and domain databases
Gene3Di | 2.40.37.10. 2 hits. 3.20.20.10. 1 hit. |
HAMAPi | MF_01201. Ala_racemase. 1 hit. |
InterProi | View protein in InterPro IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. IPR029066. PLP-binding_barrel. |
Pfami | View protein in Pfam PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. |
PRINTSi | PR00992. ALARACEMASE. |
SMARTi | View protein in SMART SM01005. Ala_racemase_C. 1 hit. |
SUPFAMi | SSF50621. SSF50621. 1 hit. SSF51419. SSF51419. 1 hit. |
TIGRFAMsi | TIGR00492. alr. 1 hit. |
PROSITEi | View protein in PROSITE PS00395. ALANINE_RACEMASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
E4RPE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKKLEKSKR PVWVEIDLNN LKFNIKEIKK TLNSDTIFTA VVKADGYGHG
60 70 80 90 100
AVPTAEAAIE AGADRLAVAI PEEGIELREA GIAAPIEILG ELLPEQLPEL
110 120 130 140 150
IRYDLIPTIS KFKTAERLNN LCAGYNLKKK IHLNIDTGMN RVGVNYKKAL
160 170 180 190 200
PLLKKITELP NLEIEGIMTH FARADELEKE YTLIQWERFN QLIEKLEAEN
210 220 230 240 250
IEIPIKHCAN SAAVIDFPEF ALDMVRAGIM IYGLKPSPDL KNNFNLKAVL
260 270 280 290 300
SWKSRIVRLK DVPAGEGISY GSEYITPKRE KIATIPLGYA DGYARILGNK
310 320 330 340 350
ASVLVKGKRA PIRGRICMDQ FMVDVSGIEG VKVGDEVVLI GSQNGLSLSA
360 370
DKLAEQAGTI NYEIVSRISK RVARIYK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP002304 Genomic DNA. Translation: ADQ13828.1. |
RefSeqi | WP_013404934.1. NC_014654.1. |
Genome annotation databases
EnsemblBacteriai | ADQ13828; ADQ13828; Halsa_0353. |
KEGGi | has:Halsa_0353. |
Entry informationi
Entry namei | E4RPE3_HALHG | |
Accessioni | E4RPE3Primary (citable) accession number: E4RPE3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 28, 2018 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |