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E4RPE3

- E4RPE3_HALHG

UniProt

E4RPE3 - E4RPE3_HALHG

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Protein

Alanine racemase

Gene
Halsa_0353
Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei141 – 1411Substrate By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei318 – 3181Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHHYD656519:GHYV-362-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Halsa_0353Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
ProteomesiUP000007434: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4RPE3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4RPE3-1 [UniParc]FASTAAdd to Basket

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MLKKLEKSKR PVWVEIDLNN LKFNIKEIKK TLNSDTIFTA VVKADGYGHG    50
AVPTAEAAIE AGADRLAVAI PEEGIELREA GIAAPIEILG ELLPEQLPEL 100
IRYDLIPTIS KFKTAERLNN LCAGYNLKKK IHLNIDTGMN RVGVNYKKAL 150
PLLKKITELP NLEIEGIMTH FARADELEKE YTLIQWERFN QLIEKLEAEN 200
IEIPIKHCAN SAAVIDFPEF ALDMVRAGIM IYGLKPSPDL KNNFNLKAVL 250
SWKSRIVRLK DVPAGEGISY GSEYITPKRE KIATIPLGYA DGYARILGNK 300
ASVLVKGKRA PIRGRICMDQ FMVDVSGIEG VKVGDEVVLI GSQNGLSLSA 350
DKLAEQAGTI NYEIVSRISK RVARIYK 377
Length:377
Mass (Da):41,849
Last modified:February 8, 2011 - v1
Checksum:iFD06B63011385E11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002304 Genomic DNA. Translation: ADQ13828.1.
RefSeqiWP_013404934.1. NC_014654.1.
YP_003994182.1. NC_014654.1.

Genome annotation databases

EnsemblBacteriaiADQ13828; ADQ13828; Halsa_0353.
GeneIDi9967943.
KEGGihas:Halsa_0353.
PATRICi42639256. VBIHalSp157090_0377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002304 Genomic DNA. Translation: ADQ13828.1 .
RefSeqi WP_013404934.1. NC_014654.1.
YP_003994182.1. NC_014654.1.

3D structure databases

ProteinModelPortali E4RPE3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ13828 ; ADQ13828 ; Halsa_0353 .
GeneIDi 9967943.
KEGGi has:Halsa_0353.
PATRICi 42639256. VBIHalSp157090_0377.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HHYD656519:GHYV-362-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: sapolanicus.

Entry informationi

Entry nameiE4RPE3_HALHG
AccessioniPrimary (citable) accession number: E4RPE3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi