Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E4RPE3 (E4RPE3_HALHG) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. RuleBase RU004247 HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site431Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2701Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1411Substrate By similarity HAMAP-Rule MF_01201
Binding site3181Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue431N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
E4RPE3 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: FD06B63011385E11

FASTA37741,849
        10         20         30         40         50         60 
MLKKLEKSKR PVWVEIDLNN LKFNIKEIKK TLNSDTIFTA VVKADGYGHG AVPTAEAAIE 

        70         80         90        100        110        120 
AGADRLAVAI PEEGIELREA GIAAPIEILG ELLPEQLPEL IRYDLIPTIS KFKTAERLNN 

       130        140        150        160        170        180 
LCAGYNLKKK IHLNIDTGMN RVGVNYKKAL PLLKKITELP NLEIEGIMTH FARADELEKE 

       190        200        210        220        230        240 
YTLIQWERFN QLIEKLEAEN IEIPIKHCAN SAAVIDFPEF ALDMVRAGIM IYGLKPSPDL 

       250        260        270        280        290        300 
KNNFNLKAVL SWKSRIVRLK DVPAGEGISY GSEYITPKRE KIATIPLGYA DGYARILGNK 

       310        320        330        340        350        360 
ASVLVKGKRA PIRGRICMDQ FMVDVSGIEG VKVGDEVVLI GSQNGLSLSA DKLAEQAGTI 

       370 
NYEIVSRISK RVARIYK

« Hide

References

[1]"Complete sequence of Halanaerobium sp. sapolanicus."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Begemann M.B. expand/collapse author list , Mormile M.R., Wall J.D., Elias D.A., Woyke T.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: sapolanicus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002304 Genomic DNA. Translation: ADQ13828.1.
RefSeqYP_003994182.1. NC_014654.1.

3D structure databases

ProteinModelPortalE4RPE3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ13828; ADQ13828; Halsa_0353.
GeneID9967943.
KEGGhas:Halsa_0353.
PATRIC42639256. VBIHalSp157090_0377.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycHHYD656519:GHYV-362-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4RPE3_HALHG
AccessionPrimary (citable) accession number: E4RPE3
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info