Halsa_0353

Functionⁱ

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityⁱ

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactorⁱ

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayⁱ: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Alanine racemase (Halsa_0353)

This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	43	Proton acceptor; specific for D-alanineUniRule annotation	1
Binding siteⁱ	141	SubstrateUniRule annotation	1
Active siteⁱ	270	Proton acceptor; specific for L-alanineUniRule annotation	1
Binding siteⁱ	318	Substrate; via amide nitrogenUniRule annotation	1

GO - Molecular functionⁱ

alanine racemase activity Source: UniProtKB-UniRule
pyridoxal phosphate binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

D-alanine biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IsomeraseUniRule annotationSAAS annotationImported
Ligand	Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCycⁱ	HHYD656519:G1GOZ-361-MONOMER.
UniPathwayⁱ	UPA00042; UER00497.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesⁱ	Ordered Locus Names:Halsa_0353Imported
Organismⁱ	Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifierⁱ	656519 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Halanaerobiales › Halanaerobiaceae › Halanaerobium
Proteomesⁱ	UP000007434 Componentⁱ: Chromosome

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	43	N6-(pyridoxal phosphate)lysineUniRule annotation		1

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	656519.Halsa_0353.

STRINGⁱ

656519.Halsa_0353.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E4RPE3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	249 – 377	Ala_racemase_CInterPro annotationAdd BLAST		129

Sequence similaritiesⁱ

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CJ4. Bacteria. COG0787. LUCA.
KEGG Orthology (KO) More...KOⁱ	K01775.
OMAⁱ	WRGPILL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H022F.

Family and domain databases

Gene3Dⁱ	2.40.37.10. 2 hits. 3.20.20.10. 1 hit.
HAMAPⁱ	MF_01201. Ala_racemase. 1 hit.
InterProⁱ	View protein in InterPro IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. IPR029066. PLP-binding_barrel.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit.
PRINTSⁱ	PR00992. ALARACEMASE.
SMARTⁱ	View protein in SMART SM01005. Ala_racemase_C. 1 hit.
SUPFAMⁱ	SSF50621. SSF50621. 1 hit. SSF51419. SSF51419. 1 hit.
TIGRFAMsⁱ	TIGR00492. alr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00395. ALANINE_RACEMASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E4RPE3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLKKLEKSKR PVWVEIDLNN LKFNIKEIKK TLNSDTIFTA VVKADGYGHG 
        60         70         80         90        100
AVPTAEAAIE AGADRLAVAI PEEGIELREA GIAAPIEILG ELLPEQLPEL 
       110        120        130        140        150
IRYDLIPTIS KFKTAERLNN LCAGYNLKKK IHLNIDTGMN RVGVNYKKAL 
       160        170        180        190        200
PLLKKITELP NLEIEGIMTH FARADELEKE YTLIQWERFN QLIEKLEAEN 
       210        220        230        240        250
IEIPIKHCAN SAAVIDFPEF ALDMVRAGIM IYGLKPSPDL KNNFNLKAVL 
       260        270        280        290        300
SWKSRIVRLK DVPAGEGISY GSEYITPKRE KIATIPLGYA DGYARILGNK 
       310        320        330        340        350
ASVLVKGKRA PIRGRICMDQ FMVDVSGIEG VKVGDEVVLI GSQNGLSLSA 
       360        370 
DKLAEQAGTI NYEIVSRISK RVARIYK

Length:377

Mass (Da):41,849

Last modified:February 8, 2011 - v1

Checksum:ⁱFD06B63011385E11

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002304 Genomic DNA. Translation: ADQ13828.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013404934.1. NC_014654.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADQ13828; ADQ13828; Halsa_0353.
KEGGⁱ	has:Halsa_0353.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002304 Genomic DNA. Translation: ADQ13828.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013404934.1. NC_014654.1.

3D structure databases

ProteinModelPortalⁱ	E4RPE3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	656519.Halsa_0353.

STRINGⁱ

656519.Halsa_0353.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADQ13828; ADQ13828; Halsa_0353.
KEGGⁱ	has:Halsa_0353.

Phylogenomic databases

eggNOGⁱ	ENOG4105CJ4. Bacteria. COG0787. LUCA.
KEGG Orthology (KO) More...KOⁱ	K01775.
OMAⁱ	WRGPILL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H022F.

Enzyme and pathway databases

UniPathwayⁱ	UPA00042; UER00497.
BioCycⁱ	HHYD656519:G1GOZ-361-MONOMER.

Family and domain databases

Gene3Dⁱ	2.40.37.10. 2 hits. 3.20.20.10. 1 hit.
HAMAPⁱ	MF_01201. Ala_racemase. 1 hit.
InterProⁱ	View protein in InterPro IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. IPR029066. PLP-binding_barrel.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit.
PRINTSⁱ	PR00992. ALARACEMASE.
SMARTⁱ	View protein in SMART SM01005. Ala_racemase_C. 1 hit.
SUPFAMⁱ	SSF50621. SSF50621. 1 hit. SSF51419. SSF51419. 1 hit.
TIGRFAMsⁱ	TIGR00492. alr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00395. ALANINE_RACEMASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E4RPE3_HALHG
Accessionⁱ	E4RPE3Primary (citable) accession number: E4RPE3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 8, 2011
	Last sequence update:	February 8, 2011
	Last modified:	February 28, 2018
	This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E4RPE3 (E4RPE3_HALHG)

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Alanine racemase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: D-alanine biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: D-alanine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ