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Protein

Thymidine kinase

Gene

tdk

Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciHHYD656519:G1GOZ-396-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Halsa_0388Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
Proteomesi
  • UP000007434 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi656519.Halsa_0388

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
KOiK00857
OMAiCAGLDQD
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

E4RP38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKITKSGWI EVITGPMYCG KSEELIRRLR RVKIAKQKIK VFKALIDDRY
60 70 80 90 100
NKNDVVSHSG NSLEAIPIEK ADEILEQIDG TVNVVGIDEA QFFHDDLIEI
110 120 130 140 150
CEKLADRGIR VIVAGLDRNF RSEPFGPMPE LMARAEYVDK LHAICIQCGE
160 170 180 190
PASRTQRLIN GEPAAYDDPV ILVAASEVYE ARCRSCHQVK GQDKEQD
Length:197
Mass (Da):22,248
Last modified:February 8, 2011 - v1
Checksum:i537E5141139628CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002304 Genomic DNA Translation: ADQ13863.1
RefSeqiWP_013404969.1, NC_014654.1

Genome annotation databases

EnsemblBacteriaiADQ13863; ADQ13863; Halsa_0388
KEGGihas:Halsa_0388

Similar proteinsi

Entry informationi

Entry nameiE4RP38_HALHG
AccessioniPrimary (citable) accession number: E4RP38
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health