E4RN22 (E4RN22_HALSL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glycine dehydrogenase (Decarboxylating) EMBL ADQ14239.1
EC=1.4.4.2 EMBL ADQ14239.1

Gene names

Ordered Locus Names:

Halsa_0792

Organism

Halanaerobium sp. (strain sapolanicus) [Complete proteome] [HAMAP]

Taxonomic identifier

656519 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Halanaerobiales › Halanaerobiaceae › Halanaerobium

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. SAAS SAAS020581
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. SAAS SAAS020581
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020581
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. SAAS SAAS020581

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020581
Molecular function	Oxidoreductase SAAS SAAS020581 EMBL ADQ14239.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E4RN22 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 9D19C691EF533039	FASTA	478	53,320
	10 20 30 40 50 60 MIIVKDDNIK GEEKKLAKRA FPYIPNSVEE IKAELLEDIG LSDVEDIFKE IPDHLRFDGK 70 80 90 100 110 120 LNIPEPKLSE YELKKHVERI LSKNESAQNN LNFKGGGVWQ HYVPSVCRTI AGRDEFLTAY 130 140 150 160 170 180 VGDAYADHGK FQALFETASM IGELVELDAV NTPTYDWSNA IVRSIRMASR INGRKEVLIP 190 200 210 220 230 240 ASMSPSRKKV VLNYCKPDIK VTEVDFDQDT ALINLDDLQA KLSDQVSSVY IENPNYLGYL 250 260 270 280 290 300 EISAQKIGEL THQHGAEFIV GVDPSSLGVL EAPANYGADM VCGELQPFGL NMKWGGALSG 310 320 330 340 350 360 FIASPDEEKY VGEYPSLLFG ITPTVEEGEY GFGHVAFERT SYAQREKGKD FIGTSTALYG 370 380 390 400 410 420 IVAGVYLALV GPKGLIELGE GIMQRCEYAK KKFAEIEGVS VPIKTPSFKE FVVDFSGCNK 430 440 450 460 470 SVKEINQLLE EENIFGGIDL GEKMEEYENC ALFCFTEVHD RYDINKLINS IEMIIEKY

References

[1]

"Complete sequence of Halanaerobium sp. sapolanicus." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Begemann M.B. , Mormile M.R., Wall J.D., Elias D.A., Woyke T. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: sapolanicus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002304 Genomic DNA. Translation: ADQ14239.1.
RefSeq	YP_003994593.1. NC_014654.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADQ14239; ADQ14239; Halsa_0792.
GeneID	9968382.
KEGG	has:Halsa_0792.
PATRIC	42640166. VBIHalSp157090_0832.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00282.
Enzyme and pathway databases
BioCyc	HHYD656519:GHYV-795-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E4RN22_HALSL

Accession

Primary (citable) accession number: E4RN22

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)