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E4RN22 (E4RN22_HALHG) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=1.4.4.2 EMBL ADQ14239.1
Gene names
Ordered Locus Names:Halsa_0792 EMBL ADQ14239.1
OrganismHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)) [Complete proteome] [HAMAP] EMBL ADQ14239.1
Taxonomic identifier656519 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. SAAS SAAS020580

Catalytic activity

Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2.

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. SAAS SAAS020580

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS020580

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. SAAS SAAS020580

Sequences

Sequence LengthMass (Da)Tools
E4RN22 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 9D19C691EF533039

FASTA47853,320
        10         20         30         40         50         60 
MIIVKDDNIK GEEKKLAKRA FPYIPNSVEE IKAELLEDIG LSDVEDIFKE IPDHLRFDGK 

        70         80         90        100        110        120 
LNIPEPKLSE YELKKHVERI LSKNESAQNN LNFKGGGVWQ HYVPSVCRTI AGRDEFLTAY 

       130        140        150        160        170        180 
VGDAYADHGK FQALFETASM IGELVELDAV NTPTYDWSNA IVRSIRMASR INGRKEVLIP 

       190        200        210        220        230        240 
ASMSPSRKKV VLNYCKPDIK VTEVDFDQDT ALINLDDLQA KLSDQVSSVY IENPNYLGYL 

       250        260        270        280        290        300 
EISAQKIGEL THQHGAEFIV GVDPSSLGVL EAPANYGADM VCGELQPFGL NMKWGGALSG 

       310        320        330        340        350        360 
FIASPDEEKY VGEYPSLLFG ITPTVEEGEY GFGHVAFERT SYAQREKGKD FIGTSTALYG 

       370        380        390        400        410        420 
IVAGVYLALV GPKGLIELGE GIMQRCEYAK KKFAEIEGVS VPIKTPSFKE FVVDFSGCNK 

       430        440        450        460        470 
SVKEINQLLE EENIFGGIDL GEKMEEYENC ALFCFTEVHD RYDINKLINS IEMIIEKY 

« Hide

References

[1]"Complete sequence of Halanaerobium sp. sapolanicus."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Begemann M.B. expand/collapse author list , Mormile M.R., Wall J.D., Elias D.A., Woyke T.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: sapolanicus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002304 Genomic DNA. Translation: ADQ14239.1.
RefSeqYP_003994593.1. NC_014654.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ14239; ADQ14239; Halsa_0792.
GeneID9968382.
KEGGhas:Halsa_0792.
PATRIC42640166. VBIHalSp157090_0832.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00282.

Enzyme and pathway databases

BioCycHHYD656519:GHYV-796-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE4RN22_HALHG
AccessionPrimary (citable) accession number: E4RN22
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)