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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

Halsa_0792

Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.SAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1SAAS annotation (EC:1.4.4.2SAAS annotation)
Gene namesi
Ordered Locus Names:Halsa_0792Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
Proteomesi
  • UP000007434 Componenti: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.SAAS annotation

Protein-protein interaction databases

STRINGi656519.Halsa_0792

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
KOiK00282
OMAiMEYPSRL
OrthoDBiPOG091H0JKN

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

E4RN22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIVKDDNIK GEEKKLAKRA FPYIPNSVEE IKAELLEDIG LSDVEDIFKE
60 70 80 90 100
IPDHLRFDGK LNIPEPKLSE YELKKHVERI LSKNESAQNN LNFKGGGVWQ
110 120 130 140 150
HYVPSVCRTI AGRDEFLTAY VGDAYADHGK FQALFETASM IGELVELDAV
160 170 180 190 200
NTPTYDWSNA IVRSIRMASR INGRKEVLIP ASMSPSRKKV VLNYCKPDIK
210 220 230 240 250
VTEVDFDQDT ALINLDDLQA KLSDQVSSVY IENPNYLGYL EISAQKIGEL
260 270 280 290 300
THQHGAEFIV GVDPSSLGVL EAPANYGADM VCGELQPFGL NMKWGGALSG
310 320 330 340 350
FIASPDEEKY VGEYPSLLFG ITPTVEEGEY GFGHVAFERT SYAQREKGKD
360 370 380 390 400
FIGTSTALYG IVAGVYLALV GPKGLIELGE GIMQRCEYAK KKFAEIEGVS
410 420 430 440 450
VPIKTPSFKE FVVDFSGCNK SVKEINQLLE EENIFGGIDL GEKMEEYENC
460 470
ALFCFTEVHD RYDINKLINS IEMIIEKY
Length:478
Mass (Da):53,320
Last modified:February 8, 2011 - v1
Checksum:i9D19C691EF533039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002304 Genomic DNA Translation: ADQ14239.1

Genome annotation databases

EnsemblBacteriaiADQ14239; ADQ14239; Halsa_0792
KEGGihas:Halsa_0792

Similar proteinsi

Entry informationi

Entry nameiE4RN22_HALHG
AccessioniPrimary (citable) accession number: E4RN22
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 25, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health