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Protein

Argininosuccinate synthase

Gene

argG

Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei92CitrullineUniRule annotation1
Binding sitei122ATP; via amide nitrogenUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei128AspartateUniRule annotation1
Binding sitei128CitrullineUniRule annotation1
Binding sitei129AspartateUniRule annotation1
Binding sitei132CitrullineUniRule annotation1
Binding sitei181CitrullineUniRule annotation1
Binding sitei190CitrullineUniRule annotation1
Binding sitei266CitrullineUniRule annotation1
Binding sitei278CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHYD656519:G1GOZ-732-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Halsa_0733Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
Proteomesi
  • UP000007434 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi656519.Halsa_0733.

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CDH. Bacteria.
COG0137. LUCA.
KOiK01940.
OMAiGVGRIDM.
OrthoDBiPOG091H01U0.

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR11587. PTHR11587. 1 hit.
PfamiView protein in Pfam
PF00764. Arginosuc_synth. 1 hit.
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiView protein in PROSITE
PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E4RMW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEKDKINK ILLAYSGGLD TSVAIKWLQD KYDAEIITYT ADLGQKQDWD
60 70 80 90 100
EVEAKALKTG ASKAYIDDIR EEFITDYVYP ALKVNALYQE KYPLATALAR
110 120 130 140 150
PLIAKRMVEV AKKENVDALA HGCTGKGNDQ VRFEVTFKAL APELAILAPL
160 170 180 190 200
RDWGFTSRDD EIEYAAENNI DVKATKDSPY SIDQNLWGVS IECGILEDPW
210 220 230 240 250
AEPPSDAYLW TKDVDDTPEE PKYIEIEFEK GVPTAVDGEK LSPIQIVNKL
260 270 280 290 300
NEAGSEYGVG RIDMVEDRLV GIKSREIYEA PAGEILITAH KALESLTLDR
310 320 330 340 350
ESKNYKAEMA AKYAELCYYG LWFSPLRDAL DAFVDKTQSY VSGTVKVKLY
360 370 380 390 400
KGNCTLAGRK SDYSLYDHGL ATYDESDVFD HESAAGFINL WALPVQVANE

KNRK
Length:404
Mass (Da):45,293
Last modified:February 8, 2011 - v1
Checksum:iFA05D9FDB44268CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002304 Genomic DNA. Translation: ADQ14183.1.
RefSeqiWP_013405275.1. NC_014654.1.

Genome annotation databases

EnsemblBacteriaiADQ14183; ADQ14183; Halsa_0733.
KEGGihas:Halsa_0733.

Similar proteinsi

Entry informationi

Entry nameiE4RMW6_HALHG
AccessioniPrimary (citable) accession number: E4RMW6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported