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E4RKM9

- E4RKM9_HALHG

UniProt

E4RKM9 - E4RKM9_HALHG

Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. histidinol-phosphate transaminase activity Source: UniProtKB-HAMAP
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHHYD656519:GHYV-2334-MONOMER.
    UniPathwayiUPA00031; UER00012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
    Alternative name(s):
    Imidazole acetol-phosphate transaminaseUniRule annotation
    Gene namesi
    Name:hisCUniRule annotation
    Ordered Locus Names:Halsa_2268Imported
    OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
    Taxonomic identifieri656519 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
    ProteomesiUP000007434: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei243 – 2431N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00817.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01023. HisC_aminotrans_2.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01141. hisC. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4RKM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIQLESELK KVKKVSNNQK DKEKIIKEML RDEVRSISPY YGEEDDFEVK    50
    INLAGNESPF DLPAKIKDKF INEFQKTDIN RYPEIYSEKI HQELADYLSS 100
    ELNKEVSTKE VIIGNGSDEL LDILIRTFVE KGDIVLSQAP TFSMYRYFSE 150
    LGGGIYEEIP LDKDFTIENI KAKIDRLQPK LIFFCSPNNP TGEILAKDLI 200
    LSITEYFSGP VIVDEAYADF SKEDLMAQVE NHANLAVTRT FSKAFGLAGI 250
    RLGYLYGNSV LVEELKKVLK PYNLNTLTDI LGCIVLNNND IIKERIEFIK 300
    KERERVFEHL KSYSDWDLFP SEANFIYLEG KKTHLFKKAL NQAGIKIRSY 350
    NTKPAAIRIT IGSEEENDAV LRVLEEFKQN N 381
    Length:381
    Mass (Da):43,799
    Last modified:February 8, 2011 - v1
    Checksum:i0578C160B94376C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002304 Genomic DNA. Translation: ADQ15676.1.
    RefSeqiWP_013406740.1. NC_014654.1.
    YP_003996030.1. NC_014654.1.

    Genome annotation databases

    EnsemblBacteriaiADQ15676; ADQ15676; Halsa_2268.
    GeneIDi9969920.
    KEGGihas:Halsa_2268.
    PATRICi42643340. VBIHalSp157090_2359.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002304 Genomic DNA. Translation: ADQ15676.1 .
    RefSeqi WP_013406740.1. NC_014654.1.
    YP_003996030.1. NC_014654.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ15676 ; ADQ15676 ; Halsa_2268 .
    GeneIDi 9969920.
    KEGGi has:Halsa_2268.
    PATRICi 42643340. VBIHalSp157090_2359.

    Phylogenomic databases

    KOi K00817.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00012 .
    BioCyci HHYD656519:GHYV-2334-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01023. HisC_aminotrans_2.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01141. hisC. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: sapolanicusImported.

    Entry informationi

    Entry nameiE4RKM9_HALHG
    AccessioniPrimary (citable) accession number: E4RKM9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3