E4RKM9 (E4RKM9_HALSL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase HAMAP-Rule MF_01023
EC=2.6.1.9 HAMAP-Rule MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase HAMAP-Rule MF_01023

Gene names

Name:	hisC1
Synonyms:	hisC HAMAP-Rule MF_01023
Ordered Locus Names:	Halsa_2268

Organism

Halanaerobium sp. (strain sapolanicus) [Complete proteome] [HAMAP]

Taxonomic identifier

656519 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Halanaerobiales › Halanaerobiaceae › Halanaerobium

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP-Rule MF_01023 SAAS SAAS005861
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_01023 SAAS SAAS005861
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP-Rule MF_01023 SAAS SAAS005861
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP-Rule MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP-Rule MF_01023 SAAS SAAS005861
Ligand	Pyridoxal phosphate HAMAP-Rule MF_01023 SAAS SAAS005861
Molecular function	Aminotransferase HAMAP-Rule MF_01023 SAAS SAAS005861 EMBL ADQ15676.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	243	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01023

Sequences

	Sequence		Length	Mass (Da)
	E4RKM9 [UniParc]. Last modified February 8, 2011. Version 1. Checksum: 0578C160B94376C8	FASTA	381	43,799
	10 20 30 40 50 60 MQIQLESELK KVKKVSNNQK DKEKIIKEML RDEVRSISPY YGEEDDFEVK INLAGNESPF 70 80 90 100 110 120 DLPAKIKDKF INEFQKTDIN RYPEIYSEKI HQELADYLSS ELNKEVSTKE VIIGNGSDEL 130 140 150 160 170 180 LDILIRTFVE KGDIVLSQAP TFSMYRYFSE LGGGIYEEIP LDKDFTIENI KAKIDRLQPK 190 200 210 220 230 240 LIFFCSPNNP TGEILAKDLI LSITEYFSGP VIVDEAYADF SKEDLMAQVE NHANLAVTRT 250 260 270 280 290 300 FSKAFGLAGI RLGYLYGNSV LVEELKKVLK PYNLNTLTDI LGCIVLNNND IIKERIEFIK 310 320 330 340 350 360 KERERVFEHL KSYSDWDLFP SEANFIYLEG KKTHLFKKAL NQAGIKIRSY NTKPAAIRIT 370 380 IGSEEENDAV LRVLEEFKQN N

References

[1]

"Complete sequence of Halanaerobium sp. sapolanicus." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Begemann M.B. , Mormile M.R., Wall J.D., Elias D.A., Woyke T. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: sapolanicus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002304 Genomic DNA. Translation: ADQ15676.1.
RefSeq	YP_003996030.1. NC_014654.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADQ15676; ADQ15676; Halsa_2268.
GeneID	9969920.
KEGG	has:Halsa_2268.
PATRIC	42643340. VBIHalSp157090_2359.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00817.
Enzyme and pathway databases
BioCyc	HHYD656519:GHYV-2333-MONOMER.
UniPathway	UPA00031; UER00012.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAP	MF_01023. HisC_aminotrans_2.
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E4RKM9_HALSL

Accession

Primary (citable) accession number: E4RKM9

Entry history

Integrated into UniProtKB/TrEMBL:	February 8, 2011
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)