Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHHYD656519:G1GOZ-2316-MONOMER
UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:Halsa_2268Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
Proteomesi
  • UP000007434 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi656519.Halsa_2268

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 373Aminotran_1_2InterPro annotationAdd BLAST324

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
KOiK00817
OMAiWRDPWPV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

E4RKM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIQLESELK KVKKVSNNQK DKEKIIKEML RDEVRSISPY YGEEDDFEVK
60 70 80 90 100
INLAGNESPF DLPAKIKDKF INEFQKTDIN RYPEIYSEKI HQELADYLSS
110 120 130 140 150
ELNKEVSTKE VIIGNGSDEL LDILIRTFVE KGDIVLSQAP TFSMYRYFSE
160 170 180 190 200
LGGGIYEEIP LDKDFTIENI KAKIDRLQPK LIFFCSPNNP TGEILAKDLI
210 220 230 240 250
LSITEYFSGP VIVDEAYADF SKEDLMAQVE NHANLAVTRT FSKAFGLAGI
260 270 280 290 300
RLGYLYGNSV LVEELKKVLK PYNLNTLTDI LGCIVLNNND IIKERIEFIK
310 320 330 340 350
KERERVFEHL KSYSDWDLFP SEANFIYLEG KKTHLFKKAL NQAGIKIRSY
360 370 380
NTKPAAIRIT IGSEEENDAV LRVLEEFKQN N
Length:381
Mass (Da):43,799
Last modified:February 8, 2011 - v1
Checksum:i0578C160B94376C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002304 Genomic DNA Translation: ADQ15676.1
RefSeqiWP_013406740.1, NC_014654.1

Genome annotation databases

EnsemblBacteriaiADQ15676; ADQ15676; Halsa_2268
KEGGihas:Halsa_2268

Similar proteinsi

Entry informationi

Entry nameiE4RKM9_HALHG
AccessioniPrimary (citable) accession number: E4RKM9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 25, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health