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E4RKM9

- E4RKM9_HALHG

UniProt

E4RKM9 - E4RKM9_HALHG

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Protein
Histidinol-phosphate aminotransferase
Gene
hisC, Halsa_2268
Organism
Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. histidinol-phosphate transaminase activity Source: UniProtKB-HAMAP
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHHYD656519:GHYV-2334-MONOMER.
UniPathwayiUPA00031; UER00012.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:Halsa_2268Imported
OrganismiHalanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus))Imported
Taxonomic identifieri656519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalanaerobium
ProteomesiUP000007434: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00817.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4RKM9-1 [UniParc]FASTAAdd to Basket

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MQIQLESELK KVKKVSNNQK DKEKIIKEML RDEVRSISPY YGEEDDFEVK    50
INLAGNESPF DLPAKIKDKF INEFQKTDIN RYPEIYSEKI HQELADYLSS 100
ELNKEVSTKE VIIGNGSDEL LDILIRTFVE KGDIVLSQAP TFSMYRYFSE 150
LGGGIYEEIP LDKDFTIENI KAKIDRLQPK LIFFCSPNNP TGEILAKDLI 200
LSITEYFSGP VIVDEAYADF SKEDLMAQVE NHANLAVTRT FSKAFGLAGI 250
RLGYLYGNSV LVEELKKVLK PYNLNTLTDI LGCIVLNNND IIKERIEFIK 300
KERERVFEHL KSYSDWDLFP SEANFIYLEG KKTHLFKKAL NQAGIKIRSY 350
NTKPAAIRIT IGSEEENDAV LRVLEEFKQN N 381
Length:381
Mass (Da):43,799
Last modified:February 8, 2011 - v1
Checksum:i0578C160B94376C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002304 Genomic DNA. Translation: ADQ15676.1.
RefSeqiWP_013406740.1. NC_014654.1.
YP_003996030.1. NC_014654.1.

Genome annotation databases

EnsemblBacteriaiADQ15676; ADQ15676; Halsa_2268.
GeneIDi9969920.
KEGGihas:Halsa_2268.
PATRICi42643340. VBIHalSp157090_2359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002304 Genomic DNA. Translation: ADQ15676.1 .
RefSeqi WP_013406740.1. NC_014654.1.
YP_003996030.1. NC_014654.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ15676 ; ADQ15676 ; Halsa_2268 .
GeneIDi 9969920.
KEGGi has:Halsa_2268.
PATRICi 42643340. VBIHalSp157090_2359.

Phylogenomic databases

KOi K00817.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00012 .
BioCyci HHYD656519:GHYV-2334-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01023. HisC_aminotrans_2.
InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01141. hisC. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: sapolanicus.

Entry informationi

Entry nameiE4RKM9_HALHG
AccessioniPrimary (citable) accession number: E4RKM9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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