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E4RHW3

- E4RHW3_PSEPB

UniProt

E4RHW3 - E4RHW3_PSEPB

Protein

Alanine racemase

Gene

alr

Organism
Pseudomonas putida (strain BIRD-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPPUT931281:GLIU-2024-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:PPUBIRD1_2040Imported
    OrganismiPseudomonas putida (strain BIRD-1)Imported
    Taxonomic identifieri931281 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000008715: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE4RHW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiQQIPCVA.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4RHW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNGTNTLTV QNSNAWVEVS ASALQHNIRT LQAELAGKSK LCAVLKADAY    50
    GHGIGLVMPS IIAQGVPCVA VASNEEARVV RASGFTGQLV RVRLASLSEL 100
    EDGLQYDMEE LVGSAEFARQ ADAIAARHGK TLRIHMALNS SGMSRNGVEM 150
    ATWSGRGEAL QITDQKHLKL VALMTHFAVE DKDDVRKGLA AFNEQTDWLI 200
    KHAKLDRSKL TLHAANSFAT LEVPEARLDM VRTGGALFGD TVPGRTEYKR 250
    AMQFKSHVAA VHSYPAGNTV GYDRTFTLAR DSRLANITVG YSDGYRRVFT 300
    NKGHVLINGH RVPVVGKVSM NTLMVDVTDF PDVKGGNEVV LFGKQAGGEI 350
    TQAEMEEING ALLADLYTVW GSSNPKMLVD 380
    Length:380
    Mass (Da):41,138
    Last modified:February 8, 2011 - v1
    Checksum:i48DE849B2DD04559
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002290 Genomic DNA. Translation: ADR59688.1.
    RefSeqiWP_014590554.1. NC_017530.1.
    YP_005929893.1. NC_017530.1.

    Genome annotation databases

    EnsemblBacteriaiADR59688; ADR59688; PPUBIRD1_2040.
    GeneIDi12520257.
    KEGGippb:PPUBIRD1_2040.
    PATRICi45406028. VBIPsePut176522_2057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002290 Genomic DNA. Translation: ADR59688.1 .
    RefSeqi WP_014590554.1. NC_017530.1.
    YP_005929893.1. NC_017530.1.

    3D structure databases

    ProteinModelPortali E4RHW3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADR59688 ; ADR59688 ; PPUBIRD1_2040 .
    GeneIDi 12520257.
    KEGGi ppb:PPUBIRD1_2040.
    PATRICi 45406028. VBIPsePut176522_2057.

    Phylogenomic databases

    KOi K01775.
    OMAi QQIPCVA.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci PPUT931281:GLIU-2024-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome of the plant-growth promoting rhizobacteria Pseudomonas putida BIRD-1."
      Matilla M.A., Pizarro P., Roca A., Fernandez M., Duque E., Molina L., van der Lelie D., Gomez M.J., Ramos J.-L.
      Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BIRD-1.
    2. "Complete genome of the plant growth-promoting rhizobacterium Pseudomonas putida BIRD-1."
      Matilla M.A., Pizarro-Tobias P., Roca A., Fernandez M., Duque E., Molina L., Wu X., van der Lelie D., Gomez M.J., Segura A., Ramos J.L.
      J. Bacteriol. 193:1290-1290(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BIRD-1Imported.

    Entry informationi

    Entry nameiE4RHW3_PSEPB
    AccessioniPrimary (citable) accession number: E4RHW3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3