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Protein

Alanine racemase

Gene

alr

Organism
Pseudomonas putida (strain BIRD-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation
Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPPUT931281:GLIU-2024-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:PPUBIRD1_2040Imported
OrganismiPseudomonas putida (strain BIRD-1)Imported
Taxonomic identifieri931281 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000008715: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4RHW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiNTVMVDV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4RHW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNGTNTLTV QNSNAWVEVS ASALQHNIRT LQAELAGKSK LCAVLKADAY
60 70 80 90 100
GHGIGLVMPS IIAQGVPCVA VASNEEARVV RASGFTGQLV RVRLASLSEL
110 120 130 140 150
EDGLQYDMEE LVGSAEFARQ ADAIAARHGK TLRIHMALNS SGMSRNGVEM
160 170 180 190 200
ATWSGRGEAL QITDQKHLKL VALMTHFAVE DKDDVRKGLA AFNEQTDWLI
210 220 230 240 250
KHAKLDRSKL TLHAANSFAT LEVPEARLDM VRTGGALFGD TVPGRTEYKR
260 270 280 290 300
AMQFKSHVAA VHSYPAGNTV GYDRTFTLAR DSRLANITVG YSDGYRRVFT
310 320 330 340 350
NKGHVLINGH RVPVVGKVSM NTLMVDVTDF PDVKGGNEVV LFGKQAGGEI
360 370 380
TQAEMEEING ALLADLYTVW GSSNPKMLVD
Length:380
Mass (Da):41,138
Last modified:February 8, 2011 - v1
Checksum:i48DE849B2DD04559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002290 Genomic DNA. Translation: ADR59688.1.
RefSeqiWP_014590554.1. NC_017530.1.
YP_005929893.1. NC_017530.1.

Genome annotation databases

EnsemblBacteriaiADR59688; ADR59688; PPUBIRD1_2040.
GeneIDi12520257.
KEGGippb:PPUBIRD1_2040.
PATRICi45406028. VBIPsePut176522_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002290 Genomic DNA. Translation: ADR59688.1.
RefSeqiWP_014590554.1. NC_017530.1.
YP_005929893.1. NC_017530.1.

3D structure databases

ProteinModelPortaliE4RHW3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADR59688; ADR59688; PPUBIRD1_2040.
GeneIDi12520257.
KEGGippb:PPUBIRD1_2040.
PATRICi45406028. VBIPsePut176522_2057.

Phylogenomic databases

KOiK01775.
OMAiNTVMVDV.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPPUT931281:GLIU-2024-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome of the plant-growth promoting rhizobacteria Pseudomonas putida BIRD-1."
    Matilla M.A., Pizarro P., Roca A., Fernandez M., Duque E., Molina L., van der Lelie D., Gomez M.J., Ramos J.-L.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BIRD-1.
  2. "Complete genome of the plant growth-promoting rhizobacterium Pseudomonas putida BIRD-1."
    Matilla M.A., Pizarro-Tobias P., Roca A., Fernandez M., Duque E., Molina L., Wu X., van der Lelie D., Gomez M.J., Segura A., Ramos J.L.
    J. Bacteriol. 193:1290-1290(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BIRD-1Imported.

Entry informationi

Entry nameiE4RHW3_PSEPB
AccessioniPrimary (citable) accession number: E4RHW3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.