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Protein

Beta-galactosidase

Gene

lacZ1

Organism
Bifidobacterium longum subsp. longum (strain BBMN68)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotation, Hydrolase

Enzyme and pathway databases

BioCyciBLON890402:GJ8K-1868-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotationSAAS annotation (EC:3.2.1.23UniRule annotationSAAS annotation)
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZ1Imported
Ordered Locus Names:BBMN68_1812Imported
OrganismiBifidobacterium longum subsp. longum (strain BBMN68)Imported
Taxonomic identifieri890402 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000006891: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252444.
KOiK01190.
OMAiTNRHEHH.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4R489-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQHPIPTTIA SSDWLTDPTV FAVNREPAHS DHRFYDHVPQ PNETMSLKQN
60 70 80 90 100
LDGLWNVAVT TAPVFGFPMN DSGNAESPDF TATDYDDTGF SRIAVPSTLE
110 120 130 140 150
TKGLLNHKYV NVQYPWDGHS DPKAPNIPTD GHVAIYRRTF ETSTPVSAAI
160 170 180 190 200
ENKRRITLTF HGASTAIYVW LNGSFVGYAE DSYTPSEFDV TEALISGTNT
210 220 230 240 250
LAVACYEYAT ASWLEDQDFW RMHGLFRSVE LTAQPTVHIE DLHITADFEA
260 270 280 290 300
TTHAGTIDAH AVIRNIADAK QLSAALMDAN GTPVWQDSYA MSDIVDTSGV
310 320 330 340 350
PCCGTADAAI DSTAVQFRAN LANIRPWSAE KPYLYTLALT VRAADNSIIE
360 370 380 390 400
VVPQRLGFRH FEIVDGIMRL NGKRIIFRGA NRHEFDARLG RAITEQEMLT
410 420 430 440 450
DIITCKRNNI NAIRTSHYPN QTRFYELCDE YGLYLIDETN LETHGSWTIP
460 470 480 490 500
GDVETPETAI PGSNPIWEGP CVDRIASMIG RDRNHPSVLI WSLGNESYAG
510 520 530 540 550
EVFRAMYRFA HAADSTRPVH YEGVVHDRPF DDVTDIETRM YAKPAEIEEY
560 570 580 590 600
LTNDPKKPYI SCEYMHAMGN SVGGMHLYTE LERYPHYQGG FIWDFIDQAL
610 620 630 640 650
WQQLDDGTER LTYGGDWDDR PCDYEFAGDG LVFADHSPSP KLQEVKRLYA
660 670 680 690 700
PVVLTVSDHD VTIENRNLFV STIDFAFTAK LLADGNAIWQ ADYRFDVPAG
710 720 730 740 750
ETRTFPIDFP SVDAAGEITY EVDQSLATAT PWAPADYELA FGQHTVQSVV
760 770 780 790 800
PASAGTDSTA CGAVPSTADS DTSDTGTVTV GRWNIGVVSG DGRTEALLSR
810 820 830 840 850
TQGGMVSFKR DGREMVLRRP AITCFRPLTD NDRGNGSGFD RVRWFGAGRY
860 870 880 890 900
ARIANQQFSQ TETGVIAEYT YTLAEPGETQ VAVRYEVDAA SGRVHLAARY
910 920 930 940 950
AGATDAPTLP AFGLEWTLPK QYENLRFYGL GPEETYRDRL HGGKLGIFER
960 970 980 990 1000
TAAEDNAPYL VPQETGNHED VRWAEVLDAQ GHGMRISQAG SEHFAASLLP
1010 1020 1030 1040 1050
YSSLMLEEAT HQNELPPVRH TFLRLLAAQM GVGGDDSWGA PVHEQYQLPA
1060
DRAYTLDVNL ELF
Length:1,063
Mass (Da):118,086
Last modified:February 8, 2011 - v1
Checksum:i9C92D5242F62A6F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002286 Genomic DNA. Translation: ADQ02870.1.
RefSeqiWP_013410710.1. NC_014656.1.
YP_004001410.1. NC_014656.1.

Genome annotation databases

EnsemblBacteriaiADQ02870; ADQ02870; BBMN68_1812.
GeneIDi9958558.
KEGGiblb:BBMN68_1812.
PATRICi42583375. VBIBifLon171405_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002286 Genomic DNA. Translation: ADQ02870.1.
RefSeqiWP_013410710.1. NC_014656.1.
YP_004001410.1. NC_014656.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADQ02870; ADQ02870; BBMN68_1812.
GeneIDi9958558.
KEGGiblb:BBMN68_1812.
PATRICi42583375. VBIBifLon171405_1875.

Phylogenomic databases

HOGENOMiHOG000252444.
KOiK01190.
OMAiTNRHEHH.

Enzyme and pathway databases

BioCyciBLON890402:GJ8K-1868-MONOMER.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Bifidobacterium longum subsp. longum BBMN68, a new strain from a healthy chinese centenarian."
    Hao Y., Huang D., Guo H., Xiao M., An H., Zhao L., Zuo F., Zhang B., Hu S., Song S., Chen S., Ren F.
    J. Bacteriol. 193:787-788(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BBMN68Imported.

Entry informationi

Entry nameiE4R489_BIFLM
AccessioniPrimary (citable) accession number: E4R489
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.