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E4R3F9 (E4R3F9_BIFLM) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoserine aminotransferase HAMAP-Rule MF_00160

EC=2.6.1.52 HAMAP-Rule MF_00160
Alternative name(s):
Phosphohydroxythreonine aminotransferase HAMAP-Rule MF_00160
Gene names
Name:serC HAMAP-Rule MF_00160 EMBL ADQ02734.1
Ordered Locus Names:BBMN68_1690 EMBL ADQ02734.1
OrganismBifidobacterium longum subsp. longum (strain BBMN68) [Complete proteome] [HAMAP] EMBL ADQ02734.1
Taxonomic identifier890402 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. HAMAP-Rule MF_00160

Catalytic activity

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP-Rule MF_00160 SAAS SAAS022278

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP-Rule MF_00160 SAAS SAAS022278

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP-Rule MF_00160 SAAS SAAS022278

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP-Rule MF_00160 SAAS SAAS022278

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP-Rule MF_00160

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00160 SAAS SAAS022278

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00160 SAAS SAAS022278.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. HAMAP-Rule MF_00160

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region80 – 812Pyridoxal phosphate binding By similarity HAMAP-Rule MF_00160
Region255 – 2562Pyridoxal phosphate binding By similarity HAMAP-Rule MF_00160

Sites

Binding site461L-glutamate By similarity HAMAP-Rule MF_00160
Binding site1041Pyridoxal phosphate By similarity HAMAP-Rule MF_00160
Binding site1501Pyridoxal phosphate By similarity HAMAP-Rule MF_00160
Binding site1741Pyridoxal phosphate By similarity HAMAP-Rule MF_00160
Binding site1971Pyridoxal phosphate By similarity HAMAP-Rule MF_00160

Amino acid modifications

Modified residue1981N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00160

Sequences

Sequence LengthMass (Da)Tools
E4R3F9 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 2539EEDE1BD38B12

FASTA38040,632
        10         20         30         40         50         60 
MTITLSIPES LKPEDGRFGS GPSKIRPEQI AALDAGATTL LGTSHRQAPV KQLVASIREG 

        70         80         90        100        110        120 
LREFFHLPEG YEVALGNGGA SAFWEIACAS LITRRAAFGT YGSFSAKFAA SAANAPFLED 

       130        140        150        160        170        180 
PVLFPGEPGT YRLPELTEGV DTYCWAHNET STGVAAPIRR VAGSREAGAL TVIDGTSAAG 

       190        200        210        220        230        240 
ALPVDISQTD VYYFSPQKAF GADGGLWVAI LSPEAIDRAA GVESSAHLEG AHRWVPPFLS 

       250        260        270        280        290        300 
LTTALNNSRK DQTLNTPAVA TLIMMENQIR WLNNNGGLAW ATTRCAKSAS ILYSWAERSE 

       310        320        330        340        350        360 
YAAPFVVDAD ARSNAVVTID LDERVQASQV LSILRENGIV DAAGYRKLGR NQLRVGVFPS 

       370        380 
VEPADVMAFT KCVDYVVEHL 

« Hide

References

[1]"Complete genome sequence of Bifidobacterium longum subsp. longum BBMN68, a new strain from a healthy chinese centenarian."
Hao Y., Huang D., Guo H., Xiao M., An H., Zhao L., Zuo F., Zhang B., Hu S., Song S., Chen S., Ren F.
J. Bacteriol. 193:787-788(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BBMN68 EMBL ADQ02734.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002286 Genomic DNA. Translation: ADQ02734.1.
RefSeqYP_004001288.1. NC_014656.1.

3D structure databases

ProteinModelPortalE4R3F9.
SMRE4R3F9. Positions 5-380.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ02734; ADQ02734; BBMN68_1690.
GeneID9958421.
KEGGblb:BBMN68_1690.
PATRIC42583113. VBIBifLon171405_1750.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000239573.
KOK00831.

Enzyme and pathway databases

BioCycBLON890402:GJ8K-1740-MONOMER.
UniPathwayUPA00135; UER00197.
UPA00244; UER00311.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00160. SerC_aminotrans_5.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR022278. Pser_aminoTfrase.
IPR006272. Pser_aminoTfrase_mycobac.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR21152:SF8. PTHR21152:SF8. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000525. SerC. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01366. serC_3. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE4R3F9_BIFLM
AccessionPrimary (citable) accession number: E4R3F9
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)