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E4R3F9

- E4R3F9_BIFLM

UniProt

E4R3F9 - E4R3F9_BIFLM

Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Bifidobacterium longum subsp. longum (strain BBMN68)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotationSAAS annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotationSAAS annotation
    O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461L-glutamateUniRule annotation
    Binding sitei104 – 1041Pyridoxal phosphateUniRule annotation
    Binding sitei150 – 1501Pyridoxal phosphateUniRule annotation
    Binding sitei174 – 1741Pyridoxal phosphateUniRule annotation
    Binding sitei197 – 1971Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-serine biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Pyridoxine biosynthesisUniRule annotation, Serine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBLON890402:GJ8K-1740-MONOMER.
    UniPathwayiUPA00135; UER00197.
    UPA00244; UER00311.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
    Alternative name(s):
    Phosphohydroxythreonine aminotransferaseUniRule annotation
    Gene namesi
    Name:serCUniRule annotationImported
    Ordered Locus Names:BBMN68_1690Imported
    OrganismiBifidobacterium longum subsp. longum (strain BBMN68)Imported
    Taxonomic identifieri890402 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000006891: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei198 – 1981N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE4R3F9.
    SMRiE4R3F9. Positions 5-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 812Pyridoxal phosphate bindingUniRule annotation
    Regioni255 – 2562Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000239573.
    KOiK00831.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00160. SerC_aminotrans_5.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR022278. Pser_aminoTfrase.
    IPR006272. Pser_aminoTfrase_mycobac.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000525. SerC. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01366. serC_3. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E4R3F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTITLSIPES LKPEDGRFGS GPSKIRPEQI AALDAGATTL LGTSHRQAPV    50
    KQLVASIREG LREFFHLPEG YEVALGNGGA SAFWEIACAS LITRRAAFGT 100
    YGSFSAKFAA SAANAPFLED PVLFPGEPGT YRLPELTEGV DTYCWAHNET 150
    STGVAAPIRR VAGSREAGAL TVIDGTSAAG ALPVDISQTD VYYFSPQKAF 200
    GADGGLWVAI LSPEAIDRAA GVESSAHLEG AHRWVPPFLS LTTALNNSRK 250
    DQTLNTPAVA TLIMMENQIR WLNNNGGLAW ATTRCAKSAS ILYSWAERSE 300
    YAAPFVVDAD ARSNAVVTID LDERVQASQV LSILRENGIV DAAGYRKLGR 350
    NQLRVGVFPS VEPADVMAFT KCVDYVVEHL 380
    Length:380
    Mass (Da):40,632
    Last modified:February 8, 2011 - v1
    Checksum:i2539EEDE1BD38B12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002286 Genomic DNA. Translation: ADQ02734.1.
    RefSeqiYP_004001288.1. NC_014656.1.

    Genome annotation databases

    EnsemblBacteriaiADQ02734; ADQ02734; BBMN68_1690.
    GeneIDi9958421.
    KEGGiblb:BBMN68_1690.
    PATRICi42583113. VBIBifLon171405_1750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002286 Genomic DNA. Translation: ADQ02734.1 .
    RefSeqi YP_004001288.1. NC_014656.1.

    3D structure databases

    ProteinModelPortali E4R3F9.
    SMRi E4R3F9. Positions 5-380.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ02734 ; ADQ02734 ; BBMN68_1690 .
    GeneIDi 9958421.
    KEGGi blb:BBMN68_1690.
    PATRICi 42583113. VBIBifLon171405_1750.

    Phylogenomic databases

    HOGENOMi HOG000239573.
    KOi K00831.

    Enzyme and pathway databases

    UniPathwayi UPA00135 ; UER00197 .
    UPA00244 ; UER00311 .
    BioCyci BLON890402:GJ8K-1740-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00160. SerC_aminotrans_5.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR022278. Pser_aminoTfrase.
    IPR006272. Pser_aminoTfrase_mycobac.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000525. SerC. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01366. serC_3. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Bifidobacterium longum subsp. longum BBMN68, a new strain from a healthy chinese centenarian."
      Hao Y., Huang D., Guo H., Xiao M., An H., Zhao L., Zuo F., Zhang B., Hu S., Song S., Chen S., Ren F.
      J. Bacteriol. 193:787-788(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BBMN68Imported.

    Entry informationi

    Entry nameiE4R3F9_BIFLM
    AccessioniPrimary (citable) accession number: E4R3F9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3