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E4R3F9

- E4R3F9_BIFLM

UniProt

E4R3F9 - E4R3F9_BIFLM

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Protein
Phosphoserine aminotransferase
Gene
serC, BBMN68_1690
Organism
Bifidobacterium longum subsp. longum (strain BBMN68)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotationSAAS annotations
O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotationSAAS annotations

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461L-glutamate By similarityUniRule annotation
Binding sitei104 – 1041Pyridoxal phosphate By similarityUniRule annotation
Binding sitei150 – 1501Pyridoxal phosphate By similarityUniRule annotation
Binding sitei174 – 1741Pyridoxal phosphate By similarityUniRule annotation
Binding sitei197 – 1971Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-serine biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Pyridoxine biosynthesisUniRule annotation, Serine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBLON890402:GJ8K-1740-MONOMER.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Gene namesi
Name:serCUniRule annotationImported
Ordered Locus Names:BBMN68_1690Imported
OrganismiBifidobacterium longum subsp. longum (strain BBMN68)Imported
Taxonomic identifieri890402 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000006891: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE4R3F9.
SMRiE4R3F9. Positions 5-380.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 812Pyridoxal phosphate binding By similarityUniRule annotation
Regioni255 – 2562Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000239573.
KOiK00831.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR022278. Pser_aminoTfrase.
IPR006272. Pser_aminoTfrase_mycobac.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01366. serC_3. 1 hit.

Sequencei

Sequence statusi: Complete.

E4R3F9-1 [UniParc]FASTAAdd to Basket

« Hide

MTITLSIPES LKPEDGRFGS GPSKIRPEQI AALDAGATTL LGTSHRQAPV    50
KQLVASIREG LREFFHLPEG YEVALGNGGA SAFWEIACAS LITRRAAFGT 100
YGSFSAKFAA SAANAPFLED PVLFPGEPGT YRLPELTEGV DTYCWAHNET 150
STGVAAPIRR VAGSREAGAL TVIDGTSAAG ALPVDISQTD VYYFSPQKAF 200
GADGGLWVAI LSPEAIDRAA GVESSAHLEG AHRWVPPFLS LTTALNNSRK 250
DQTLNTPAVA TLIMMENQIR WLNNNGGLAW ATTRCAKSAS ILYSWAERSE 300
YAAPFVVDAD ARSNAVVTID LDERVQASQV LSILRENGIV DAAGYRKLGR 350
NQLRVGVFPS VEPADVMAFT KCVDYVVEHL 380
Length:380
Mass (Da):40,632
Last modified:February 8, 2011 - v1
Checksum:i2539EEDE1BD38B12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002286 Genomic DNA. Translation: ADQ02734.1.
RefSeqiYP_004001288.1. NC_014656.1.

Genome annotation databases

EnsemblBacteriaiADQ02734; ADQ02734; BBMN68_1690.
GeneIDi9958421.
KEGGiblb:BBMN68_1690.
PATRICi42583113. VBIBifLon171405_1750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002286 Genomic DNA. Translation: ADQ02734.1 .
RefSeqi YP_004001288.1. NC_014656.1.

3D structure databases

ProteinModelPortali E4R3F9.
SMRi E4R3F9. Positions 5-380.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ02734 ; ADQ02734 ; BBMN68_1690 .
GeneIDi 9958421.
KEGGi blb:BBMN68_1690.
PATRICi 42583113. VBIBifLon171405_1750.

Phylogenomic databases

HOGENOMi HOG000239573.
KOi K00831.

Enzyme and pathway databases

UniPathwayi UPA00135 ; UER00197 .
UPA00244 ; UER00311 .
BioCyci BLON890402:GJ8K-1740-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00160. SerC_aminotrans_5.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR022278. Pser_aminoTfrase.
IPR006272. Pser_aminoTfrase_mycobac.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF000525. SerC. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01366. serC_3. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Bifidobacterium longum subsp. longum BBMN68, a new strain from a healthy chinese centenarian."
    Hao Y., Huang D., Guo H., Xiao M., An H., Zhao L., Zuo F., Zhang B., Hu S., Song S., Chen S., Ren F.
    J. Bacteriol. 193:787-788(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BBMN68Imported.

Entry informationi

Entry nameiE4R3F9_BIFLM
AccessioniPrimary (citable) accession number: E4R3F9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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