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E4QIT0 (E4QIT0_METS6) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL ADQ83666.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:MPQ_0484 EMBL ADQ83666.1
OrganismMethylovorus sp. (strain MP688) [Complete proteome] [HAMAP] EMBL ADQ83666.1
Taxonomic identifier887061 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain120 – 315196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding146 – 20156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2691Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E4QIT0 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 005FA910B3B43C3B

FASTA32034,571
        10         20         30         40         50         60 
MRRVASKAHL QTHEPADVMM KNFGKVAVLM GGRSGEREVS LKSGGAVLAA LLRQGVEAAA 

        70         80         90        100        110        120 
FDPAERDLHE LLAFDRVFIS LHGRFGEDGT VQGALELMGI PYTGSGVLAS SVGMDKWRTK 

       130        140        150        160        170        180 
LLWRSAGIAT PDFELLDASS DFAAVEQRLG LPMFVKPANE GSSIGISKVK QSGALKAAYE 

       190        200        210        220        230        240 
LAAKSDPLVI AERFVGGGEY TVGILGDEAL PIIRIVPANE FYDFEAKYLR DDTQYLCPCG 

       250        260        270        280        290        300 
LPAEQEARIR AEALQAFRAI GGRGWGRVDF LMDEAGRHYF LEVNTSPGMT DHSLVPMAAK 

       310        320 
ANGISFDELV IRILELARVG 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of the PQQ high-production bacteria Methylovorus sp. MP688."
Xiong X., Wang J., Zhang W., Yang L., Zhi J., Wang X., Cui Y., Dong F., Li M., Yang Y., Du B.
Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MP688.
[2]"Complete genome sequence of the bacterium Methylovorus sp. strain MP688, a high-level producer of pyrroloquinolone quinone."
Xiong X.H., Zhi J.J., Yang L., Wang J.H., Zhao Y., Wang X., Cui Y.J., Dong F., Li M.X., Yang Y.X., Wei N., An J.J., Du B.H., Liang L., Zhang J.S., Zhou W., Cheng S.F., He T. expand/collapse author list , Wang L., Chen H.P., Liu D.S., Zhang W.C.
J. Bacteriol. 193:1012-1013(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MP688 EMBL ADQ83666.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002252 Genomic DNA. Translation: ADQ83666.1.
RefSeqYP_004038902.1. NC_014733.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ83666; ADQ83666; MPQ_0484.
GeneID9995322.
KEGGmep:MPQ_0484.
PATRIC45263230. VBIMetSp170262_0465.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMACSGYSRV.

Enzyme and pathway databases

BioCycMSP887061:GHJT-484-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4QIT0_METS6
AccessionPrimary (citable) accession number: E4QIT0
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)