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E4QIT0

- E4QIT0_METS6

UniProt

E4QIT0 - E4QIT0_METS6

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Protein

D-alanine--D-alanine ligase

Gene
ddlA, ddl, MPQ_0484
Organism
Methylovorus sp. (strain MP688)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi269 – 2691Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi282 – 2821Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi282 – 2821Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi284 – 2841Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi146 – 20156ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP887061:GHJT-484-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:MPQ_0484Imported
OrganismiMethylovorus sp. (strain MP688)Imported
Taxonomic identifieri887061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus
ProteomesiUP000007036: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 315196ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiCSGYSRV.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4QIT0-1 [UniParc]FASTAAdd to Basket

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MRRVASKAHL QTHEPADVMM KNFGKVAVLM GGRSGEREVS LKSGGAVLAA    50
LLRQGVEAAA FDPAERDLHE LLAFDRVFIS LHGRFGEDGT VQGALELMGI 100
PYTGSGVLAS SVGMDKWRTK LLWRSAGIAT PDFELLDASS DFAAVEQRLG 150
LPMFVKPANE GSSIGISKVK QSGALKAAYE LAAKSDPLVI AERFVGGGEY 200
TVGILGDEAL PIIRIVPANE FYDFEAKYLR DDTQYLCPCG LPAEQEARIR 250
AEALQAFRAI GGRGWGRVDF LMDEAGRHYF LEVNTSPGMT DHSLVPMAAK 300
ANGISFDELV IRILELARVG 320
Length:320
Mass (Da):34,571
Last modified:February 8, 2011 - v1
Checksum:i005FA910B3B43C3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002252 Genomic DNA. Translation: ADQ83666.1.
RefSeqiWP_013441289.1. NC_014733.1.
YP_004038902.1. NC_014733.1.

Genome annotation databases

EnsemblBacteriaiADQ83666; ADQ83666; MPQ_0484.
GeneIDi9995322.
KEGGimep:MPQ_0484.
PATRICi45263230. VBIMetSp170262_0465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002252 Genomic DNA. Translation: ADQ83666.1 .
RefSeqi WP_013441289.1. NC_014733.1.
YP_004038902.1. NC_014733.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ83666 ; ADQ83666 ; MPQ_0484 .
GeneIDi 9995322.
KEGGi mep:MPQ_0484.
PATRICi 45263230. VBIMetSp170262_0465.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi CSGYSRV.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MSP887061:GHJT-484-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the PQQ high-production bacteria Methylovorus sp. MP688."
    Xiong X., Wang J., Zhang W., Yang L., Zhi J., Wang X., Cui Y., Dong F., Li M., Yang Y., Du B.
    Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MP688.
  2. "Complete genome sequence of the bacterium Methylovorus sp. strain MP688, a high-level producer of pyrroloquinolone quinone."
    Xiong X.H., Zhi J.J., Yang L., Wang J.H., Zhao Y., Wang X., Cui Y.J., Dong F., Li M.X., Yang Y.X., Wei N., An J.J., Du B.H., Liang L., Zhang J.S., Zhou W., Cheng S.F., He T.
    , Wang L., Chen H.P., Liu D.S., Zhang W.C.
    J. Bacteriol. 193:1012-1013(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MP688Imported.

Entry informationi

Entry nameiE4QIT0_METS6
AccessioniPrimary (citable) accession number: E4QIT0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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