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E4QIT0

- E4QIT0_METS6

UniProt

E4QIT0 - E4QIT0_METS6

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Protein

D-alanine--D-alanine ligase

Gene

ddlA

Organism
Methylovorus sp. (strain MP688)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi269 – 2691Magnesium or manganese 1UniRule annotation
Metal bindingi282 – 2821Magnesium or manganese 1UniRule annotation
Metal bindingi282 – 2821Magnesium or manganese 2UniRule annotation
Metal bindingi284 – 2841Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi146 – 20156ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP887061:GHJT-484-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:MPQ_0484Imported
OrganismiMethylovorus sp. (strain MP688)Imported
Taxonomic identifieri887061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaMethylophilalesMethylophilaceaeMethylovorus
ProteomesiUP000007036: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 315196ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.
OMAiCSGYSRV.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4QIT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRVASKAHL QTHEPADVMM KNFGKVAVLM GGRSGEREVS LKSGGAVLAA
60 70 80 90 100
LLRQGVEAAA FDPAERDLHE LLAFDRVFIS LHGRFGEDGT VQGALELMGI
110 120 130 140 150
PYTGSGVLAS SVGMDKWRTK LLWRSAGIAT PDFELLDASS DFAAVEQRLG
160 170 180 190 200
LPMFVKPANE GSSIGISKVK QSGALKAAYE LAAKSDPLVI AERFVGGGEY
210 220 230 240 250
TVGILGDEAL PIIRIVPANE FYDFEAKYLR DDTQYLCPCG LPAEQEARIR
260 270 280 290 300
AEALQAFRAI GGRGWGRVDF LMDEAGRHYF LEVNTSPGMT DHSLVPMAAK
310 320
ANGISFDELV IRILELARVG
Length:320
Mass (Da):34,571
Last modified:February 8, 2011 - v1
Checksum:i005FA910B3B43C3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002252 Genomic DNA. Translation: ADQ83666.1.
RefSeqiWP_013441289.1. NC_014733.1.
YP_004038902.1. NC_014733.1.

Genome annotation databases

EnsemblBacteriaiADQ83666; ADQ83666; MPQ_0484.
GeneIDi9995322.
KEGGimep:MPQ_0484.
PATRICi45263230. VBIMetSp170262_0465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002252 Genomic DNA. Translation: ADQ83666.1 .
RefSeqi WP_013441289.1. NC_014733.1.
YP_004038902.1. NC_014733.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ83666 ; ADQ83666 ; MPQ_0484 .
GeneIDi 9995322.
KEGGi mep:MPQ_0484.
PATRICi 45263230. VBIMetSp170262_0465.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.
OMAi CSGYSRV.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MSP887061:GHJT-484-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the PQQ high-production bacteria Methylovorus sp. MP688."
    Xiong X., Wang J., Zhang W., Yang L., Zhi J., Wang X., Cui Y., Dong F., Li M., Yang Y., Du B.
    Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MP688.
  2. "Complete genome sequence of the bacterium Methylovorus sp. strain MP688, a high-level producer of pyrroloquinolone quinone."
    Xiong X.H., Zhi J.J., Yang L., Wang J.H., Zhao Y., Wang X., Cui Y.J., Dong F., Li M.X., Yang Y.X., Wei N., An J.J., Du B.H., Liang L., Zhang J.S., Zhou W., Cheng S.F., He T.
    , Wang L., Chen H.P., Liu D.S., Zhang W.C.
    J. Bacteriol. 193:1012-1013(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MP688Imported.

Entry informationi

Entry nameiE4QIT0_METS6
AccessioniPrimary (citable) accession number: E4QIT0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3