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E4Q797

- E4Q797_CALH1

UniProt

E4Q797 - E4Q797_CALH1

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Protein

Alanine racemase

Gene

alr

Organism
Caldicellulosiruptor hydrothermalis (strain DSM 18901 / VKM B-2411 / 108)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei318 – 3181Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCHYD632292:GHA8-905-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:Calhy_0881Imported
OrganismiCaldicellulosiruptor hydrothermalis (strain DSM 18901 / VKM B-2411 / 108)Imported
Taxonomic identifieri632292 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000006890: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4Q797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4Q797-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLSLYNRV WAEIDLDNLV YNLENIKKKI LPQTHIMAVV KADAYGHGAV
60 70 80 90 100
EISRVLVKNG VSMLAVAIID EALQLRHFNF DVPILILGFT PFELSEQVVE
110 120 130 140 150
NEISQTVYTY EQAYYLSQAA QKVGKKAKIH IKVDTGMGRI GFLCCDESIQ
160 170 180 190 200
TVLNIAKLPN IELEGIFSHF SSADDPDSDN FTHEQFMKFE NFVKELNKNG
210 220 230 240 250
VYFKYKHIAN SSAAIRFPQY QLDVVRLGLI LYGLYPNSSL KEHISIKPVM
260 270 280 290 300
SVKARVINVK EVPEGFPISY NRRYITTRKS KIATIPIGYA DGFTRVGSSQ
310 320 330 340 350
RHVLIKGEFA KVVGSICMDQ CMVDVTDIED VKIGDEVVII GKQGKNEILA
360 370 380 390
DHLAEQIGTI NYEIVCSFSK RIPRVYIKDG RVVKILNYIL
Length:390
Mass (Da):44,046
Last modified:February 8, 2011 - v1
Checksum:i1E6D81719C1ABC8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002219 Genomic DNA. Translation: ADQ06610.1.
RefSeqiWP_013402806.1. NC_014652.1.
YP_003991979.1. NC_014652.1.

Genome annotation databases

EnsemblBacteriaiADQ06610; ADQ06610; Calhy_0881.
GeneIDi9935412.
KEGGichd:Calhy_0881.
PATRICi42585338. VBICalHyd101559_0951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002219 Genomic DNA. Translation: ADQ06610.1 .
RefSeqi WP_013402806.1. NC_014652.1.
YP_003991979.1. NC_014652.1.

3D structure databases

ProteinModelPortali E4Q797.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ06610 ; ADQ06610 ; Calhy_0881 .
GeneIDi 9935412.
KEGGi chd:Calhy_0881.
PATRICi 42585338. VBICalHyd101559_0951.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CHYD632292:GHA8-905-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 108.
  2. "Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus."
    Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M.
    J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18901 / VKM B-2411 / 108Imported.

Entry informationi

Entry nameiE4Q797_CALH1
AccessioniPrimary (citable) accession number: E4Q797
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3