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E4Q3T5

- E4Q3T5_CALOW

UniProt

E4Q3T5 - E4Q3T5_CALOW

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Protein
Alanine racemase
Gene
alr, Calow_1619
Organism
Caldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei139 – 1391Substrate By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei318 – 3181Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCOWE632518:GHVV-1656-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:Calow_1619Imported
OrganismiCaldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL)Imported
Taxonomic identifieri632518 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000006889: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4Q3T5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4Q3T5-1 [UniParc]FASTAAdd to Basket

« Hide

MNKLSLYNRV WAEIDLDNLV YNLENIKKKI LPQTKIMAVV KADAYGHGAV    50
EISRVLVKNG VSMLAVAIID EALQLRHFNF DVPILILGFT PFELSEQVVE 100
NEISQTVYTY EQAYYLSKAA QKIGKKAKIH IKVDTGMGRI GFLCCEQSVN 150
TILNIAKLPN IELEGIFSHF SSADDPDSDD FTHEQFMKFE NFVKELNKNG 200
VYFKYKHIAN SSAAIRFPQY QLDVVRLGLI LYGLYPNSSL KEHINLKPVM 250
SIKARVINVK EVPEGFPISY NRRYITTRKS KIATIPIGYA DGFTRVGSSQ 300
RHVLIKGEFA KVVGSICMDQ CMVDVTDIED VKIGDEVVII GKQGKNEILA 350
DHLAEQIGTI NYEVVCSFSK RIPRVYIKDG RVVKILNYIL 390
Length:390
Mass (Da):44,078
Last modified:February 8, 2011 - v1
Checksum:iDD2EDBE1DC044760
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002216 Genomic DNA. Translation: ADQ05165.1.
RefSeqiYP_004002965.1. NC_014657.1.

Genome annotation databases

EnsemblBacteriaiADQ05165; ADQ05165; Calow_1619.
GeneIDi9961034.
KEGGicow:Calow_1619.
PATRICi42592525. VBICalOwe108203_1718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002216 Genomic DNA. Translation: ADQ05165.1 .
RefSeqi YP_004002965.1. NC_014657.1.

3D structure databases

ProteinModelPortali E4Q3T5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ05165 ; ADQ05165 ; Calow_1619 .
GeneIDi 9961034.
KEGGi cow:Calow_1619.
PATRICi 42592525. VBICalOwe108203_1718.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci COWE632518:GHVV-1656-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: OL.
  2. "Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensensis, and Caldicellulosiruptor lactoaceticus."
    Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M.
    J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700167 / DSM 13100 / OL.

Entry informationi

Entry nameiE4Q3T5_CALOW
AccessioniPrimary (citable) accession number: E4Q3T5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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