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E4Q3T5

- E4Q3T5_CALOW

UniProt

E4Q3T5 - E4Q3T5_CALOW

Protein

Alanine racemase

Gene

alr

Organism
Caldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation
    Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei318 – 3181Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCOWE632518:GHVV-1656-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:Calow_1619Imported
    OrganismiCaldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL)Imported
    Taxonomic identifieri632518 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000006889: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE4Q3T5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4Q3T5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKLSLYNRV WAEIDLDNLV YNLENIKKKI LPQTKIMAVV KADAYGHGAV    50
    EISRVLVKNG VSMLAVAIID EALQLRHFNF DVPILILGFT PFELSEQVVE 100
    NEISQTVYTY EQAYYLSKAA QKIGKKAKIH IKVDTGMGRI GFLCCEQSVN 150
    TILNIAKLPN IELEGIFSHF SSADDPDSDD FTHEQFMKFE NFVKELNKNG 200
    VYFKYKHIAN SSAAIRFPQY QLDVVRLGLI LYGLYPNSSL KEHINLKPVM 250
    SIKARVINVK EVPEGFPISY NRRYITTRKS KIATIPIGYA DGFTRVGSSQ 300
    RHVLIKGEFA KVVGSICMDQ CMVDVTDIED VKIGDEVVII GKQGKNEILA 350
    DHLAEQIGTI NYEVVCSFSK RIPRVYIKDG RVVKILNYIL 390
    Length:390
    Mass (Da):44,078
    Last modified:February 8, 2011 - v1
    Checksum:iDD2EDBE1DC044760
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002216 Genomic DNA. Translation: ADQ05165.1.
    RefSeqiYP_004002965.1. NC_014657.1.

    Genome annotation databases

    EnsemblBacteriaiADQ05165; ADQ05165; Calow_1619.
    GeneIDi9961034.
    KEGGicow:Calow_1619.
    PATRICi42592525. VBICalOwe108203_1718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002216 Genomic DNA. Translation: ADQ05165.1 .
    RefSeqi YP_004002965.1. NC_014657.1.

    3D structure databases

    ProteinModelPortali E4Q3T5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ05165 ; ADQ05165 ; Calow_1619 .
    GeneIDi 9961034.
    KEGGi cow:Calow_1619.
    PATRICi 42592525. VBICalOwe108203_1718.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci COWE632518:GHVV-1656-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: OL.
    2. "Complete genome sequences for the anaerobic, extremely thermophilic plant biomass-degrading bacteria Caldicellulosiruptor hydrothermalis, Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis, Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus."
      Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T., Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C., Walston-Davenport K., Han S., Adams M.W., Kelly R.M.
      J. Bacteriol. 193:1483-1484(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700167 / DSM 13100 / OLImported.

    Entry informationi

    Entry nameiE4Q3T5_CALOW
    AccessioniPrimary (citable) accession number: E4Q3T5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3