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E4PTG4

- E4PTG4_MYCLG

UniProt

E4PTG4 - E4PTG4_MYCLG

Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma leachii (strain DSM 21131 / NCTC 10133 / N29 / PG50)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Proton acceptorUniRule annotation
    Metal bindingi160 – 1601ZincUniRule annotation
    Metal bindingi163 – 1631ZincUniRule annotation
    Metal bindingi198 – 1981ZincUniRule annotation
    Metal bindingi201 – 2011ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi25 – 328ATPUniRule annotation
    Nucleotide bindingi103 – 1064ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMLEA880447:GC0N-191-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:MSB_A0193Imported
    OrganismiMycoplasma leachii (strain DSM 21131 / NCTC 10133 / N29 / PG50)Imported
    Taxonomic identifieri880447 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000008712: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4PTG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIELDINEIE AYNSNKMGWI ELITGCMFAG KTEEFIRRLK VLSYAKKRVL    50
    AFKPSIDNRY SVENIISHSG SKLDSYLVKS SDEIKQIVEK ENQIQQVDVI 100
    GIDEVQFFDE NVVDIVEQLA DNGIIVIVNG LDKDFRGLPF KNVDKLLVKA 150
    EFVTKLRARC HLCGSFANRS QRIVNGQPAL WNSPLILVDG KESYEARCRK 200
    CFIAPKKDV 209
    Length:209
    Mass (Da):23,802
    Last modified:February 8, 2011 - v1
    Checksum:i0E65FD0FECD1BB2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002108 Genomic DNA. Translation: ADR23822.1.
    RefSeqiWP_013447508.1. NC_014751.1.
    YP_004046950.1. NC_014751.1.

    Genome annotation databases

    EnsemblBacteriaiADR23822; ADR23822; MSB_A0193.
    GeneIDi10004528.
    KEGGimlc:MSB_A0193.
    PATRICi45296257. VBIMycLea173401_0190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002108 Genomic DNA. Translation: ADR23822.1 .
    RefSeqi WP_013447508.1. NC_014751.1.
    YP_004046950.1. NC_014751.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADR23822 ; ADR23822 ; MSB_A0193 .
    GeneIDi 10004528.
    KEGGi mlc:MSB_A0193.
    PATRICi 45296257. VBIMycLea173401_0190.

    Phylogenomic databases

    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.

    Enzyme and pathway databases

    BioCyci MLEA880447:GC0N-191-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Mycoplasma leachii PG50 MU clone A8."
      Wise K., Calcutt M.J., Foecking M.F., Madupu R., DeBoy R.T., Roske K., Martin T.R., Hvinden M.L., Durkin A.S., Glass J., Methe B.A.
      Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21131 / NCTC 10133 / N29 / PG50Imported.

    Entry informationi

    Entry nameiE4PTG4_MYCLG
    AccessioniPrimary (citable) accession number: E4PTG4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3