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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma leachii (strain DSM 21131 / NCTC 10133 / N29 / PG50)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptorUniRule annotation
Metal bindingi160 – 1601ZincUniRule annotation
Metal bindingi163 – 1631ZincUniRule annotation
Metal bindingi198 – 1981ZincUniRule annotation
Metal bindingi201 – 2011ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 328ATPUniRule annotation
Nucleotide bindingi103 – 1064ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMLEA880447:GC0N-191-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:MSB_A0193Imported
OrganismiMycoplasma leachii (strain DSM 21131 / NCTC 10133 / N29 / PG50)Imported
Taxonomic identifieri880447 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000008712 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4PTG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELDINEIE AYNSNKMGWI ELITGCMFAG KTEEFIRRLK VLSYAKKRVL
60 70 80 90 100
AFKPSIDNRY SVENIISHSG SKLDSYLVKS SDEIKQIVEK ENQIQQVDVI
110 120 130 140 150
GIDEVQFFDE NVVDIVEQLA DNGIIVIVNG LDKDFRGLPF KNVDKLLVKA
160 170 180 190 200
EFVTKLRARC HLCGSFANRS QRIVNGQPAL WNSPLILVDG KESYEARCRK

CFIAPKKDV
Length:209
Mass (Da):23,802
Last modified:February 8, 2011 - v1
Checksum:i0E65FD0FECD1BB2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002108 Genomic DNA. Translation: ADR23822.1.
RefSeqiWP_013447508.1. NC_014751.1.
YP_004046950.1. NC_014751.1.

Genome annotation databases

EnsemblBacteriaiADR23822; ADR23822; MSB_A0193.
KEGGimlc:MSB_A0193.
PATRICi45296257. VBIMycLea173401_0190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002108 Genomic DNA. Translation: ADR23822.1.
RefSeqiWP_013447508.1. NC_014751.1.
YP_004046950.1. NC_014751.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADR23822; ADR23822; MSB_A0193.
KEGGimlc:MSB_A0193.
PATRICi45296257. VBIMycLea173401_0190.

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Enzyme and pathway databases

BioCyciMLEA880447:GC0N-191-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Mycoplasma leachii PG50 MU clone A8."
    Wise K., Calcutt M.J., Foecking M.F., Madupu R., DeBoy R.T., Roske K., Martin T.R., Hvinden M.L., Durkin A.S., Glass J., Methe B.A.
    Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21131 / NCTC 10133 / N29 / PG50Imported.

Entry informationi

Entry nameiE4PTG4_MYCLG
AccessioniPrimary (citable) accession number: E4PTG4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 27, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.