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E4PP18 (E4PP18_MARAH) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL ADP96330.1
Ordered Locus Names:HP15_566 EMBL ADP96330.1
OrganismMarinobacter adhaerens (strain HP15) [Complete proteome] [HAMAP] EMBL ADP96330.1
Taxonomic identifier225937 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain118 – 315198ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding144 – 19956ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2691Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E4PP18 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 0271E105B7E0E9E6

FASTA32334,954
        10         20         30         40         50         60 
MHHGEPQAYQ ADPELVRSLG RVAVFMGGDS AEREVSLKSG KAVLAALVSA GVDAFAVDVR 

        70         80         90        100        110        120 
GCLLRTVDNP DFDRVFIALH GRGGEDGTLQ AILSQAGIPY TGSDVLASAL AMDKLRTKYV 

       130        140        150        160        170        180 
FEGCGLPTPK FRTMSGADQA EQIIDELRAP LSVKPSREGS SIGIRKVHTA AELAHAYEAA 

       190        200        210        220        230        240 
AALDNLVLVE EWIEGPEFTV SLLQDRALPA IGLSASTEHV FYDYEAKYLA DDTRYRIPCG 

       250        260        270        280        290        300 
LAPEDEVRLQ HLALEAFRVV GCRTWGRVDI MQDSDGKFWL LEVNTVPGMT DHSLVPMAAK 

       310        320 
AAGISFEELV VRILKDSLED ANA 

« Hide

References

[1]"Complete genome sequence of Marinobacter adhaerens type strain (HP15)."
Gaerdes A.A.M., Kaeppel E., Shezad A., Seebah S., Teeling H., Yarza P., Gloeckner F.O., Ullrich M.S.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HP15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001978 Genomic DNA. Translation: ADP96330.1.
RefSeqYP_005884258.1. NC_017506.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADP96330; ADP96330; HP15_566.
GeneID12400581.
KEGGmad:HP15_566.
PATRIC43113279. VBIMarBac104501_0573.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMADTQYRIP.

Enzyme and pathway databases

BioCycMADH225937:GLG5-583-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4PP18_MARAH
AccessionPrimary (citable) accession number: E4PP18
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)