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Protein

Peptidoglycan D,D-transpeptidase FtsI

Gene

ftsI

Organism
Marinobacter adhaerens (strain DSM 23420 / HP15)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.UniRule annotation

Catalytic activityi

Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei305Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, Protease
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation, SeptationUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan D,D-transpeptidase FtsIUniRule annotation (EC:3.4.16.4UniRule annotation)
Alternative name(s):
Penicillin-binding protein 3UniRule annotation
Short name:
PBP-3UniRule annotation
Gene namesi
Name:ftsIUniRule annotation
Ordered Locus Names:HP15_558Imported
OrganismiMarinobacter adhaerens (strain DSM 23420 / HP15)Imported
Taxonomic identifieri225937 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000007077 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 42HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi225937.HP15_558

Structurei

3D structure databases

ProteinModelPortaliE4PP10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 218PBP_dimerInterPro annotationAdd BLAST150
Domaini258 – 553TranspeptidaseInterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the transpeptidase family. FtsI subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJN Bacteria
COG0768 LUCA
KOiK03587
OMAiNVGMIKI
OrthoDBiPOG091H01T5

Family and domain databases

HAMAPiMF_02080 FtsI_transpept, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR037532 FtsI_transpept
IPR005311 PBP_dimer
IPR036138 PBP_dimer_sf
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF03717 PBP_dimer, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56519 SSF56519, 1 hit
SSF56601 SSF56601, 1 hit

Sequencei

Sequence statusi: Complete.

E4PP10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDVSDQGKK TTWGQRLASG LAAWRFGSVV GVFLLVVGVL GWRLVDLHVV
60 70 80 90 100
DNDFLRKQGD VRTIRVESID AHRGVVTDRY DEPLAVSTPV QTIWANPSEA
110 120 130 140 150
NPSEARLTNL ARLLDINEAS LRQRLEEYSG REFIYLRRKV QPDLARKVLE
160 170 180 190 200
LEIDGIYTRQ EYRRYYPAGE VTAHVVGFTD IDERGQEGIE LAYNQWLSGE
210 220 230 240 250
TGRKRVLKDN RGRVIKDLTL IRDASPGQNL ALSIDLRLQY LAYRELKAVV
260 270 280 290 300
AAHNARGGTL VMLDVDTGEV LAMVNQGSYN PNDRSQLAAE NLRNKAITDL
310 320 330 340 350
FEPGSTMKPI TMAAALESGS YSVNSTIDTN PGFRRFGRFT IRDHRNYGVM
360 370 380 390 400
DMTEIIVKSS NVGISRIATD LGGDVIRDLY ARLGLGQPTG IGFPGEAVGV
410 420 430 440 450
LPSPPKWRPV EEATLSYGYG MSVNALQLAQ AYMVIANGGV RYPLSLVRQD
460 470 480 490 500
KKPEGQRVLS EQVTLQVRNM LREAVSRGTG KRAQPGFYSA GGKTGTVHLV
510 520 530 540 550
GAQGYEDSQY KAIFAGMAPI DNPRLVTVVA VDAPQSGEYY GGEVAAPVFS
560 570 580
RVMSDALRLL NVKPELEVGE AEMAASASGE RG
Length:582
Mass (Da):63,907
Last modified:February 8, 2011 - v1
Checksum:iB0DDDAB7B62B5D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001978 Genomic DNA Translation: ADP96322.1

Genome annotation databases

EnsemblBacteriaiADP96322; ADP96322; HP15_558
KEGGimad:HP15_558
PATRICifig|225937.3.peg.565

Similar proteinsi

Entry informationi

Entry nameiE4PP10_MARAH
AccessioniPrimary (citable) accession number: E4PP10
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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