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Protein

Beta-galactosidase

Gene

lacZ5

Organism
Bifidobacterium bifidum (strain PRL2010)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Active sitei161 – 1611Proton donorUniRule annotation
Active sitei320 – 3201NucleophileUniRule annotation
Binding sitei328 – 3281SubstrateUniRule annotation

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. galactose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Enzyme and pathway databases

BioCyciBBIF702459:GHBC-1312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Gene namesi
Name:lacZ5Imported
Ordered Locus Names:BBPR_1355Imported
OrganismiBifidobacterium bifidum (strain PRL2010)Imported
Taxonomic identifieri702459 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002312: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000117811.
KOiK12308.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

E4NY78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRRKHSWP QPLKGAESRL WYGGDYNPDQ WPEEVWDDDI RLMKKAGVNL
60 70 80 90 100
VSVGIFSWAK IEPEEGKYDF DWLDRAIDKL GKAGIAVDLA SATASPPMWL
110 120 130 140 150
TQAHPEVLWK DERGDTVWPG AREHWRPTSP VFREYALNLC RRMAEHYKGN
160 170 180 190 200
PYVVAWHVSN EYGCHNRFDY SDDAMRAFQK WCKKRYKTID AVNEAWGTAF
210 220 230 240 250
WAQHMNDFSE IIPPRYIGDG NFMNPGKLLD YKRFSSDALK ELYIAERDVL
260 270 280 290 300
ESITPGLPLT TNFMVSAGGS MLDYDDWGAE VDFVSNDHYF TPGEDHFDEV
310 320 330 340 350
AYAASLMDGI SRKEPWFQME HSTSAVNWRP INYRAEPGSV VRDSLAQVAM
360 370 380 390 400
GADAICYFQW RQSKAGAEKW HSSMVPHAGE DSQIFRDVCE LGADLGRLSD
410 420 430 440 450
EGLMGTKTVK SKVAVVFDYE SQWATEYTAN PTQQVDHWTE PLDWFRALAD
460 470 480 490 500
NGITADVVPV RSDWDSYEIA VLPCVYLLSE ETSRRVREFV ANGGKLFVTY
510 520 530 540 550
YTGLSDENDH IWLGGYPGSI RDVVGVRVEE FAPMGNDMPG ALDHLDLDNG
560 570 580 590 600
TVAHDFADVI TSTADTSTVL ASYKAERWTG MNEVPAIVAN GYGDGRTVYV
610 620 630 640 650
GCRLGRQGLA KSLPAMLGSM GLSDLAGDGR VLRVERADAA AASHFEFVFN
660 670 680
RTHEPVTVDV EGEAIAASLA HVDDGRATID PTGVVVLRR
Length:689
Mass (Da):77,234
Last modified:February 8, 2011 - v1
Checksum:iC13E7161F5B63947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001840 Genomic DNA. Translation: ADP36405.1.
RefSeqiYP_003971442.1. NC_014638.1.

Genome annotation databases

EnsemblBacteriaiADP36405; ADP36405; BBPR_1355.
GeneIDi9889488.
KEGGibbp:BBPR_1355.
PATRICi42578442. VBIBifBif153886_1403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001840 Genomic DNA. Translation: ADP36405.1.
RefSeqiYP_003971442.1. NC_014638.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADP36405; ADP36405; BBPR_1355.
GeneIDi9889488.
KEGGibbp:BBPR_1355.
PATRICi42578442. VBIBifBif153886_1403.

Phylogenomic databases

HOGENOMiHOG000117811.
KOiK12308.

Enzyme and pathway databases

BioCyciBBIF702459:GHBC-1312-MONOMER.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRL2010Imported.

Entry informationi

Entry nameiE4NY78_BIFBP
AccessioniPrimary (citable) accession number: E4NY78
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: January 7, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.