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E4NXZ0

- E4NXZ0_BIFBP

UniProt

E4NXZ0 - E4NXZ0_BIFBP

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Protein

Alanine racemase

Gene

alr

Organism
Bifidobacterium bifidum (strain PRL2010)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Active sitei303 – 3031Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei367 – 3671Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBBIF702459:GHBC-1292-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BBPR_1338Imported
OrganismiBifidobacterium bifidum (strain PRL2010)Imported
Taxonomic identifieri702459 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002312: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4NXZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4NXZ0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLNAASELQ FSSPAGEANY RAARRRYPAQ AIVDLATLRD NMAHLVDVVG
60 70 80 90 100
GPHSGTAVMG VVKADAYGHG LLPAALAALA GGATWLGTAQ SHEALLLRKL
110 120 130 140 150
GIGPDRCRIL TWVYNGMDVP FDELIDNDID ISVGSLAGID ALADAARRLG
160 170 180 190 200
KPARVHVKVD SGFGRNGFTP AGFDAALAKL VPLAHEGVLH IVGQWSHLAV
210 220 230 240 250
ADSPDVPEFV ASTDRQIESF TEFTRRMEAA GIAPEIRHLA NTAATLNRPE
260 270 280 290 300
IHLELTRPGI GLYGYEPDPA MGTPRDWHLK PAMTLQAQLG TVKDVEAGHG
310 320 330 340 350
VSYGRTYLTP DNTSTAIVPL GYADGIHRSA SGFDMQGAKH VEKAGGPVRV
360 370 380 390 400
MTSAGPRLLH VCGRVCMDQF IVDLHGSAAE LGVHEGDTVE LFGPGRGEQY
410 420 430 440 450
GEPTADDWAR AADTISYEVF TCLRNRIPRL YLHAADVLPA ADLAKLDPAS

LL
Length:452
Mass (Da):48,115
Last modified:February 8, 2011 - v1
Checksum:i03D7FFB6AEAA4E45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001840 Genomic DNA. Translation: ADP36388.1.
RefSeqiWP_003813965.1. NC_014638.1.
YP_003971425.1. NC_014638.1.

Genome annotation databases

EnsemblBacteriaiADP36388; ADP36388; BBPR_1338.
GeneIDi9889468.
KEGGibbp:BBPR_1338.
PATRICi42578400. VBIBifBif153886_1385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001840 Genomic DNA. Translation: ADP36388.1 .
RefSeqi WP_003813965.1. NC_014638.1.
YP_003971425.1. NC_014638.1.

3D structure databases

ProteinModelPortali E4NXZ0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP36388 ; ADP36388 ; BBPR_1338 .
GeneIDi 9889468.
KEGGi bbp:BBPR_1338.
PATRICi 42578400. VBIBifBif153886_1385.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BBIF702459:GHBC-1292-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRL2010Imported.

Entry informationi

Entry nameiE4NXZ0_BIFBP
AccessioniPrimary (citable) accession number: E4NXZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3