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E4NXZ0

- E4NXZ0_BIFBP

UniProt

E4NXZ0 - E4NXZ0_BIFBP

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Protein

Alanine racemase

Gene
alr, BBPR_1338
Organism
Bifidobacterium bifidum (strain PRL2010)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Active sitei303 – 3031Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei367 – 3671Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBBIF702459:GHBC-1292-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BBPR_1338Imported
OrganismiBifidobacterium bifidum (strain PRL2010)Imported
Taxonomic identifieri702459 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002312: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4NXZ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4NXZ0-1 [UniParc]FASTAAdd to Basket

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MTLNAASELQ FSSPAGEANY RAARRRYPAQ AIVDLATLRD NMAHLVDVVG    50
GPHSGTAVMG VVKADAYGHG LLPAALAALA GGATWLGTAQ SHEALLLRKL 100
GIGPDRCRIL TWVYNGMDVP FDELIDNDID ISVGSLAGID ALADAARRLG 150
KPARVHVKVD SGFGRNGFTP AGFDAALAKL VPLAHEGVLH IVGQWSHLAV 200
ADSPDVPEFV ASTDRQIESF TEFTRRMEAA GIAPEIRHLA NTAATLNRPE 250
IHLELTRPGI GLYGYEPDPA MGTPRDWHLK PAMTLQAQLG TVKDVEAGHG 300
VSYGRTYLTP DNTSTAIVPL GYADGIHRSA SGFDMQGAKH VEKAGGPVRV 350
MTSAGPRLLH VCGRVCMDQF IVDLHGSAAE LGVHEGDTVE LFGPGRGEQY 400
GEPTADDWAR AADTISYEVF TCLRNRIPRL YLHAADVLPA ADLAKLDPAS 450
LL 452
Length:452
Mass (Da):48,115
Last modified:February 8, 2011 - v1
Checksum:i03D7FFB6AEAA4E45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001840 Genomic DNA. Translation: ADP36388.1.
RefSeqiWP_003813965.1. NC_014638.1.
YP_003971425.1. NC_014638.1.

Genome annotation databases

EnsemblBacteriaiADP36388; ADP36388; BBPR_1338.
GeneIDi9889468.
KEGGibbp:BBPR_1338.
PATRICi42578400. VBIBifBif153886_1385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001840 Genomic DNA. Translation: ADP36388.1 .
RefSeqi WP_003813965.1. NC_014638.1.
YP_003971425.1. NC_014638.1.

3D structure databases

ProteinModelPortali E4NXZ0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADP36388 ; ADP36388 ; BBPR_1338 .
GeneIDi 9889468.
KEGGi bbp:BBPR_1338.
PATRICi 42578400. VBIBifBif153886_1385.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BBIF702459:GHBC-1292-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PRL2010Imported.

Entry informationi

Entry nameiE4NXZ0_BIFBP
AccessioniPrimary (citable) accession number: E4NXZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi