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E4NQ76

- E4NQ76_HALBP

UniProt

E4NQ76 - E4NQ76_HALBP

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Protein
Protein translocase subunit SecY
Gene
secY, Hbor_10460, C499_02734
Organism
Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity.UniRule annotation

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, TranslocationUniRule annotation, Transport

Enzyme and pathway databases

BioCyciHBOR469382:GCNS-1045-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Alternative name(s):
Protein transport protein SEC61 subunit alpha homolog
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:Hbor_10460Imported
ORF Names:C499_02734Imported
OrganismiHalogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)Imported
Taxonomic identifieri469382 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalogeometricum
ProteomesiUP000006663: Chromosome

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei75 – 9521Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei118 – 13821Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei152 – 17221Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei185 – 20521Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei240 – 26021Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei288 – 30821Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei322 – 34221Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei366 – 38621Helical; By similarityUniRule annotation
Add
BLAST
Transmembranei429 – 44921Helical; By similarityUniRule annotation
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000231248.
KOiK03076.
OMAiIFWIETT.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4NQ76-1 [UniParc]FASTAAdd to Basket

« Hide

MGWKEAAEPV LTRMPAVARP EGHVPFRRKL GWTAGILVMY FFLTNVTMFG    50
LQTQGPGGDF YGQFRSILAG QQGSILQLGI GPIVTASIVL QLLGGADLLG 100
LDTDDPRDQI LYQGLQKLLV VVMICLTGLP MVFAGGFLPA DQQVAQSLGV 150
GVGGVKTIIF AQMFVGGILI LFMDEIVSKW GVGSGVGLFI IAGVSQQLVA 200
GLFSWQALGG TSGFFPTWFG IITGAAEIGS PLSPGGLSDI FLGQGQLLAL 250
LTTLFIFGIV VYAESVRIEV PLSHSRVKGA RGRFPVKLIY ASVLPMILVR 300
ALQANIQFLG QILNNWTGLP AWLGTYSDGA VTGGLFYYLA PIQSRADWMW 350
FLGYTSQDPA QILLRVLIDL AFMIVGGAVF AIFWVETTGM GPESTAEQIQ 400
NSGMQIPGFR RNPQIIEQVM ERYIPQVTVI GGALVGLLAV MANMLGTIGS 450
VSGTGLLLTV SITYKLYEEI AEEQLMEMHP MMRQMFGE 488
Length:488
Mass (Da):52,527
Last modified:February 8, 2011 - v1
Checksum:i657EDD9C011513BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001690 Genomic DNA. Translation: ADQ66638.1.
AOHT01000008 Genomic DNA. Translation: ELY30745.1.
RefSeqiYP_004036083.1. NC_014729.1.

Genome annotation databases

EnsemblBacteriaiADQ66638; ADQ66638; Hbor_10460.
ELY30745; ELY30745; C499_02734.
GeneIDi9992865.
KEGGihbo:Hbor_10460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001690 Genomic DNA. Translation: ADQ66638.1 .
AOHT01000008 Genomic DNA. Translation: ELY30745.1 .
RefSeqi YP_004036083.1. NC_014729.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ66638 ; ADQ66638 ; Hbor_10460 .
ELY30745 ; ELY30745 ; C499_02734 .
GeneIDi 9992865.
KEGGi hbo:Hbor_10460.

Phylogenomic databases

HOGENOMi HOG000231248.
KOi K03076.
OMAi IFWIETT.

Enzyme and pathway databases

BioCyci HBOR469382:GCNS-1045-MONOMER.

Family and domain databases

Gene3Di 1.10.3370.10. 1 hit.
HAMAPi MF_01465. SecY.
InterProi IPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view ]
PANTHERi PTHR10906. PTHR10906. 1 hit.
Pfami PF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view ]
PIRSFi PIRSF004557. SecY. 1 hit.
SUPFAMi SSF103491. SSF103491. 1 hit.
TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
PROSITEi PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700274 / DSM 11551 / JCM 10706 / PR3 and PR 3Imported.
  2. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11551Imported.

Entry informationi

Entry nameiE4NQ76_HALBP
AccessioniPrimary (citable) accession number: E4NQ76
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 14, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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