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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Alternative name(s):
Protein transport protein SEC61 subunit alpha homologUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:Hbor_10460Imported
ORF Names:C499_02734Imported
OrganismiHalogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)Imported
Taxonomic identifieri469382 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHalogeometricum
Proteomesi
  • UP000006663 Componenti: Chromosome
  • UP000011585 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Transmembranei185 – 205HelicalUniRule annotationAdd BLAST21
Transmembranei240 – 260HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei322 – 342HelicalUniRule annotationAdd BLAST21
Transmembranei366 – 386HelicalUniRule annotationAdd BLAST21
Transmembranei429 – 449HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.UniRule annotation

Protein-protein interaction databases

STRINGi469382.Hbor_10460.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 73Plug_transloconInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiarCOG04169. Archaea.
COG0201. LUCA.
HOGENOMiHOG000231248.
KOiK03076.
OMAiRYIPYVT.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4NQ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWKEAAEPV LTRMPAVARP EGHVPFRRKL GWTAGILVMY FFLTNVTMFG
60 70 80 90 100
LQTQGPGGDF YGQFRSILAG QQGSILQLGI GPIVTASIVL QLLGGADLLG
110 120 130 140 150
LDTDDPRDQI LYQGLQKLLV VVMICLTGLP MVFAGGFLPA DQQVAQSLGV
160 170 180 190 200
GVGGVKTIIF AQMFVGGILI LFMDEIVSKW GVGSGVGLFI IAGVSQQLVA
210 220 230 240 250
GLFSWQALGG TSGFFPTWFG IITGAAEIGS PLSPGGLSDI FLGQGQLLAL
260 270 280 290 300
LTTLFIFGIV VYAESVRIEV PLSHSRVKGA RGRFPVKLIY ASVLPMILVR
310 320 330 340 350
ALQANIQFLG QILNNWTGLP AWLGTYSDGA VTGGLFYYLA PIQSRADWMW
360 370 380 390 400
FLGYTSQDPA QILLRVLIDL AFMIVGGAVF AIFWVETTGM GPESTAEQIQ
410 420 430 440 450
NSGMQIPGFR RNPQIIEQVM ERYIPQVTVI GGALVGLLAV MANMLGTIGS
460 470 480
VSGTGLLLTV SITYKLYEEI AEEQLMEMHP MMRQMFGE
Length:488
Mass (Da):52,527
Last modified:February 8, 2011 - v1
Checksum:i657EDD9C011513BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001690 Genomic DNA. Translation: ADQ66638.1.
AOHT01000008 Genomic DNA. Translation: ELY30745.1.
RefSeqiWP_006053862.1. NZ_AOHT01000008.1.

Genome annotation databases

EnsemblBacteriaiADQ66638; ADQ66638; Hbor_10460.
ELY30745; ELY30745; C499_02734.
GeneIDi9992865.
KEGGihbo:Hbor_10460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001690 Genomic DNA. Translation: ADQ66638.1.
AOHT01000008 Genomic DNA. Translation: ELY30745.1.
RefSeqiWP_006053862.1. NZ_AOHT01000008.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469382.Hbor_10460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADQ66638; ADQ66638; Hbor_10460.
ELY30745; ELY30745; C499_02734.
GeneIDi9992865.
KEGGihbo:Hbor_10460.

Phylogenomic databases

eggNOGiarCOG04169. Archaea.
COG0201. LUCA.
HOGENOMiHOG000231248.
KOiK03076.
OMAiRYIPYVT.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE4NQ76_HALBP
AccessioniPrimary (citable) accession number: E4NQ76
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.