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E4NQ76

- E4NQ76_HALBP

UniProt

E4NQ76 - E4NQ76_HALBP

Protein

Protein translocase subunit SecY

Gene

secY

Organism
Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein targeting Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, TranslocationUniRule annotation, Transport

    Enzyme and pathway databases

    BioCyciHBOR469382:GCNS-1045-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecYUniRule annotation
    Alternative name(s):
    Protein transport protein SEC61 subunit alpha homologUniRule annotation
    Gene namesi
    Name:secYUniRule annotation
    Ordered Locus Names:Hbor_10460Imported
    ORF Names:C499_02734Imported
    OrganismiHalogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)Imported
    Taxonomic identifieri469382 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalogeometricum
    ProteomesiUP000006663: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: GOC
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.UniRule annotation

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical;UniRule annotationAdd
    BLAST
    Transmembranei75 – 9521Helical;UniRule annotationAdd
    BLAST
    Transmembranei118 – 13821Helical;UniRule annotationAdd
    BLAST
    Transmembranei152 – 17221Helical;UniRule annotationAdd
    BLAST
    Transmembranei185 – 20521Helical;UniRule annotationAdd
    BLAST
    Transmembranei240 – 26021Helical;UniRule annotationAdd
    BLAST
    Transmembranei288 – 30821Helical;UniRule annotationAdd
    BLAST
    Transmembranei322 – 34221Helical;UniRule annotationAdd
    BLAST
    Transmembranei366 – 38621Helical;UniRule annotationAdd
    BLAST
    Transmembranei429 – 44921Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000231248.
    KOiK03076.
    OMAiIFWIETT.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    HAMAPiMF_01465. SecY.
    InterProiIPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    IPR019561. Translocon_Sec61/SecY_plug_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF10559. Plug_translocon. 1 hit.
    PF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4NQ76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWKEAAEPV LTRMPAVARP EGHVPFRRKL GWTAGILVMY FFLTNVTMFG    50
    LQTQGPGGDF YGQFRSILAG QQGSILQLGI GPIVTASIVL QLLGGADLLG 100
    LDTDDPRDQI LYQGLQKLLV VVMICLTGLP MVFAGGFLPA DQQVAQSLGV 150
    GVGGVKTIIF AQMFVGGILI LFMDEIVSKW GVGSGVGLFI IAGVSQQLVA 200
    GLFSWQALGG TSGFFPTWFG IITGAAEIGS PLSPGGLSDI FLGQGQLLAL 250
    LTTLFIFGIV VYAESVRIEV PLSHSRVKGA RGRFPVKLIY ASVLPMILVR 300
    ALQANIQFLG QILNNWTGLP AWLGTYSDGA VTGGLFYYLA PIQSRADWMW 350
    FLGYTSQDPA QILLRVLIDL AFMIVGGAVF AIFWVETTGM GPESTAEQIQ 400
    NSGMQIPGFR RNPQIIEQVM ERYIPQVTVI GGALVGLLAV MANMLGTIGS 450
    VSGTGLLLTV SITYKLYEEI AEEQLMEMHP MMRQMFGE 488
    Length:488
    Mass (Da):52,527
    Last modified:February 8, 2011 - v1
    Checksum:i657EDD9C011513BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001690 Genomic DNA. Translation: ADQ66638.1.
    AOHT01000008 Genomic DNA. Translation: ELY30745.1.
    RefSeqiYP_004036083.1. NC_014729.1.

    Genome annotation databases

    EnsemblBacteriaiADQ66638; ADQ66638; Hbor_10460.
    ELY30745; ELY30745; C499_02734.
    GeneIDi9992865.
    KEGGihbo:Hbor_10460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001690 Genomic DNA. Translation: ADQ66638.1 .
    AOHT01000008 Genomic DNA. Translation: ELY30745.1 .
    RefSeqi YP_004036083.1. NC_014729.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADQ66638 ; ADQ66638 ; Hbor_10460 .
    ELY30745 ; ELY30745 ; C499_02734 .
    GeneIDi 9992865.
    KEGGi hbo:Hbor_10460.

    Phylogenomic databases

    HOGENOMi HOG000231248.
    KOi K03076.
    OMAi IFWIETT.

    Enzyme and pathway databases

    BioCyci HBOR469382:GCNS-1045-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    HAMAPi MF_01465. SecY.
    InterProi IPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    IPR019561. Translocon_Sec61/SecY_plug_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF10559. Plug_translocon. 1 hit.
    PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700274 / DSM 11551 / JCM 10706 / PR3Imported and PR 3Imported.
    2. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
      Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSM 11551Imported.

    Entry informationi

    Entry nameiE4NQ76_HALBP
    AccessioniPrimary (citable) accession number: E4NQ76
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3