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E4NQ76 (E4NQ76_HALBP) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY RuleBase RU000537 HAMAP-Rule MF_01465
Alternative name(s):
Protein transport protein SEC61 subunit alpha homolog HAMAP-Rule MF_01465
Gene names
Name:secY HAMAP-Rule MF_01465
Ordered Locus Names:Hbor_10460 EMBL ADQ66638.1
ORF Names:C499_02734 EMBL ELY30745.1
OrganismHalogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3) [Complete proteome] [HAMAP] EMBL ADQ66638.1
Taxonomic identifier469382 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalogeometricum

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. RuleBase RU000537 HAMAP-Rule MF_01465

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved By similarity. HAMAP-Rule MF_01465

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Membrane; Multi-pass membrane protein By similarity RuleBase RU003484.

Sequence similarities

Belongs to the SecY/SEC61-alpha family. RuleBase RU004349 HAMAP-Rule MF_01465

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane30 – 5021Helical; By similarity HAMAP-Rule MF_01465
Transmembrane75 – 9521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane118 – 13821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane152 – 17221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane185 – 20521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane240 – 26021Helical; By similarity HAMAP-Rule MF_01465
Transmembrane288 – 30821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane322 – 34221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane366 – 38621Helical; By similarity HAMAP-Rule MF_01465
Transmembrane429 – 44921Helical; By similarity HAMAP-Rule MF_01465

Sequences

Sequence LengthMass (Da)Tools
E4NQ76 [UniParc].

Last modified February 8, 2011. Version 1.
Checksum: 657EDD9C011513BA

FASTA48852,527
        10         20         30         40         50         60 
MGWKEAAEPV LTRMPAVARP EGHVPFRRKL GWTAGILVMY FFLTNVTMFG LQTQGPGGDF 

        70         80         90        100        110        120 
YGQFRSILAG QQGSILQLGI GPIVTASIVL QLLGGADLLG LDTDDPRDQI LYQGLQKLLV 

       130        140        150        160        170        180 
VVMICLTGLP MVFAGGFLPA DQQVAQSLGV GVGGVKTIIF AQMFVGGILI LFMDEIVSKW 

       190        200        210        220        230        240 
GVGSGVGLFI IAGVSQQLVA GLFSWQALGG TSGFFPTWFG IITGAAEIGS PLSPGGLSDI 

       250        260        270        280        290        300 
FLGQGQLLAL LTTLFIFGIV VYAESVRIEV PLSHSRVKGA RGRFPVKLIY ASVLPMILVR 

       310        320        330        340        350        360 
ALQANIQFLG QILNNWTGLP AWLGTYSDGA VTGGLFYYLA PIQSRADWMW FLGYTSQDPA 

       370        380        390        400        410        420 
QILLRVLIDL AFMIVGGAVF AIFWVETTGM GPESTAEQIQ NSGMQIPGFR RNPQIIEQVM 

       430        440        450        460        470        480 
ERYIPQVTVI GGALVGLLAV MANMLGTIGS VSGTGLLLTV SITYKLYEEI AEEQLMEMHP 


MMRQMFGE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001690 Genomic DNA. Translation: ADQ66638.1.
AOHT01000008 Genomic DNA. Translation: ELY30745.1.
RefSeqYP_004036083.1. NC_014729.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADQ66638; ADQ66638; Hbor_10460.
ELY30745; ELY30745; C499_02734.
GeneID9992865.
KEGGhbo:Hbor_10460.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000231248.
KOK03076.
OMAIFWIETT.

Enzyme and pathway databases

BioCycHBOR469382:GCNS-1045-MONOMER.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SSF103491. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4NQ76_HALBP
AccessionPrimary (citable) accession number: E4NQ76
Entry history
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 14, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)