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E4NPX6

- E4NPX6_HALBP

UniProt

E4NPX6 - E4NPX6_HALBP

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561Proton acceptorUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation
Metal bindingi182 – 1821Magnesium; via carbamate groupUniRule annotation
Metal bindingi184 – 1841MagnesiumUniRule annotation
Metal bindingi185 – 1851MagnesiumUniRule annotation
Active sitei274 – 2741Proton acceptorUniRule annotation
Binding sitei275 – 2751SubstrateUniRule annotation
Binding sitei307 – 3071SubstrateUniRule annotation
Sitei315 – 3151Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHBOR469382:GCNS-2156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotationImported
Ordered Locus Names:Hbor_21570Imported
ORF Names:C499_17644Imported
OrganismiHalogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)Imported
Taxonomic identifieri469382 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalogeometricum
ProteomesiUP000006663: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei182 – 1821N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE4NPX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 3453Substrate bindingUniRule annotation
Regioni365 – 3684Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation
Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

E4NPX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGITYEDFL DLSYEPDESD LVCTFRIAPA EGMDVEAAAS RVASESSNGT
60 70 80 90 100
WAALPTGEGF TDMGATTFDI RGSDDSAEVD VAYPAGLFEP GSMPQILSCI
110 120 130 140 150
AGNIMGMKAV DTIRLADCQW PEALVSSFAG PQFGSSVREE IFGIEEDRPI
160 170 180 190 200
LATVPKPKVG LSTDRHAEVG YEAWLGGVDL LKDDENLTDQ SFNPYHDRLV
210 220 230 240 250
ESLALRDDAE DETGEKKSYL INVTADTNTM LERVDLAAEE GCEYVMVDVI
260 270 280 290 300
TTGWAAVQTV RERCEDHGIA IHAHRAMHAA FDRLENHGVS MRVLAQISRL
310 320 330 340 350
CGVDQLHTGT AGLGKLANED TVGINDWMRS ELYGLNDVLP VASGGLHPGL
360 370 380 390 400
IPDLLDATGT NVCVQAGGGI HGHPDGTRAG AAALRAAVDG YAAGKSLEES
410 420
ADDSPELATA IDEWGTETPR
Length:420
Mass (Da):44,775
Last modified:February 8, 2011 - v1
Checksum:i4CF3B80193853A63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001690 Genomic DNA. Translation: ADQ67721.1.
AOHT01000051 Genomic DNA. Translation: ELY23598.1.
RefSeqiYP_004037166.1. NC_014729.1.

Genome annotation databases

EnsemblBacteriaiADQ67721; ADQ67721; Hbor_21570.
ELY23598; ELY23598; C499_17644.
GeneIDi9993976.
KEGGihbo:Hbor_21570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001690 Genomic DNA. Translation: ADQ67721.1 .
AOHT01000051 Genomic DNA. Translation: ELY23598.1 .
RefSeqi YP_004037166.1. NC_014729.1.

3D structure databases

ProteinModelPortali E4NPX6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ67721 ; ADQ67721 ; Hbor_21570 .
ELY23598 ; ELY23598 ; C499_17644 .
GeneIDi 9993976.
KEGGi hbo:Hbor_21570.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci HBOR469382:GCNS-2156-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700274 / DSM 11551 / JCM 10706 / PR3Imported and PR 3Imported.
  2. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11551Imported.

Entry informationi

Entry nameiE4NPX6_HALBP
AccessioniPrimary (citable) accession number: E4NPX6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3