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E4NPX6

- E4NPX6_HALBP

UniProt

E4NPX6 - E4NPX6_HALBP

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, Hbor_21570, C499_17644
Organism
Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561Proton acceptor By similarityUniRule annotation
Binding sitei158 – 1581Substrate By similarityUniRule annotation
Metal bindingi182 – 1821Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi184 – 1841Magnesium By similarityUniRule annotation
Metal bindingi185 – 1851Magnesium By similarityUniRule annotation
Active sitei274 – 2741Proton acceptor By similarityUniRule annotation
Binding sitei275 – 2751Substrate By similarityUniRule annotation
Binding sitei307 – 3071Substrate By similarityUniRule annotation
Sitei315 – 3151Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHBOR469382:GCNS-2156-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotationImported
Ordered Locus Names:Hbor_21570Imported
ORF Names:C499_17644Imported
OrganismiHalogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)Imported
Taxonomic identifieri469382 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalogeometricum
ProteomesiUP000006663: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei182 – 1821N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 3453Substrate binding By similarityUniRule annotation
Regioni365 – 3684Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

E4NPX6-1 [UniParc]FASTAAdd to Basket

« Hide

MAGITYEDFL DLSYEPDESD LVCTFRIAPA EGMDVEAAAS RVASESSNGT    50
WAALPTGEGF TDMGATTFDI RGSDDSAEVD VAYPAGLFEP GSMPQILSCI 100
AGNIMGMKAV DTIRLADCQW PEALVSSFAG PQFGSSVREE IFGIEEDRPI 150
LATVPKPKVG LSTDRHAEVG YEAWLGGVDL LKDDENLTDQ SFNPYHDRLV 200
ESLALRDDAE DETGEKKSYL INVTADTNTM LERVDLAAEE GCEYVMVDVI 250
TTGWAAVQTV RERCEDHGIA IHAHRAMHAA FDRLENHGVS MRVLAQISRL 300
CGVDQLHTGT AGLGKLANED TVGINDWMRS ELYGLNDVLP VASGGLHPGL 350
IPDLLDATGT NVCVQAGGGI HGHPDGTRAG AAALRAAVDG YAAGKSLEES 400
ADDSPELATA IDEWGTETPR 420
Length:420
Mass (Da):44,775
Last modified:February 8, 2011 - v1
Checksum:i4CF3B80193853A63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001690 Genomic DNA. Translation: ADQ67721.1.
AOHT01000051 Genomic DNA. Translation: ELY23598.1.
RefSeqiWP_006056824.1. NZ_AOHT01000051.1.
YP_004037166.1. NC_014729.1.

Genome annotation databases

EnsemblBacteriaiADQ67721; ADQ67721; Hbor_21570.
ELY23598; ELY23598; C499_17644.
GeneIDi9993976.
KEGGihbo:Hbor_21570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001690 Genomic DNA. Translation: ADQ67721.1 .
AOHT01000051 Genomic DNA. Translation: ELY23598.1 .
RefSeqi WP_006056824.1. NZ_AOHT01000051.1.
YP_004037166.1. NC_014729.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADQ67721 ; ADQ67721 ; Hbor_21570 .
ELY23598 ; ELY23598 ; C499_17644 .
GeneIDi 9993976.
KEGGi hbo:Hbor_21570.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci HBOR469382:GCNS-2156-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700274 / DSM 11551 / JCM 10706 / PR3 and PR 3Imported.
  2. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 11551Imported.

Entry informationi

Entry nameiE4NPX6_HALBP
AccessioniPrimary (citable) accession number: E4NPX6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi