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Protein

Thymidine kinase

Gene

tdk

Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciKSET452652:GJFD-5434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:KSE_54240Imported
OrganismiKitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)Imported
Taxonomic identifieri452652 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeKitasatospora
ProteomesiUP000007076 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi452652.KSE_54240.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiRATHNAR.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

E4NI69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELVFFSGT MDCGKSTLAL QMDHNHAARG RQGMIFTRND RAGAATISSR
60 70 80 90 100
LGLRADAVEA GDDFDFQAYV VQLLSAGGKV DYLICDEAQF FSADQIDQLA
110 120 130 140 150
RIVDELGIDV FTFGITTDFR TRLFPGSQRL IELADRVEVL QVEALCWCGA
160 170 180 190 200
RATHNARTVG GVMVVEGAQV VVGDVTVRED EIGYEVLCRR HHRRRLTAAT
210
ARAAVLSPDV LPFEG
Length:215
Mass (Da):23,526
Last modified:February 8, 2011 - v1
Checksum:iC4A27E82691D8F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA. Translation: BAJ31199.1.
RefSeqiWP_014138496.1. NC_016109.1.
YP_004907155.1. NC_016109.1.

Genome annotation databases

EnsemblBacteriaiBAJ31199; BAJ31199; KSE_54240.
KEGGiksk:KSE_54240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA. Translation: BAJ31199.1.
RefSeqiWP_014138496.1. NC_016109.1.
YP_004907155.1. NC_016109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi452652.KSE_54240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAJ31199; BAJ31199; KSE_54240.
KEGGiksk:KSE_54240.

Phylogenomic databases

KOiK00857.
OMAiRATHNAR.

Enzyme and pathway databases

BioCyciKSET452652:GJFD-5434-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054Imported.

Entry informationi

Entry nameiE4NI69_KITSK
AccessioniPrimary (citable) accession number: E4NI69
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 24, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.