ID   E4NGS0_KITSK            Unreviewed;       464 AA.
AC   E4NGS0;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=HD-GYP domain-containing protein {ECO:0000259|PROSITE:PS51832};
GN   OrderedLocusNames=KSE_49220 {ECO:0000313|EMBL:BAJ30700.1};
OS   Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS   / NBRC 14216 / KM-6054) (Streptomyces setae).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Kitasatospora.
OX   NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ30700.1, ECO:0000313|Proteomes:UP000007076};
RN   [1] {ECO:0000313|EMBL:BAJ30700.1, ECO:0000313|Proteomes:UP000007076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC   KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX   PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA   Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA   Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA   Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA   Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA   Takahashi Y., Fujita N.;
RT   "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT   snapshot of the family Streptomycetaceae.";
RL   DNA Res. 17:393-406(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP010968; BAJ30700.1; -; Genomic_DNA.
DR   RefSeq; WP_014137999.1; NC_016109.1.
DR   AlphaFoldDB; E4NGS0; -.
DR   STRING; 452652.KSE_49220; -.
DR   KEGG; ksk:KSE_49220; -.
DR   PATRIC; fig|452652.3.peg.4914; -.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_000445_92_14_11; -.
DR   Proteomes; UP000007076; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   PANTHER; PTHR45228:SF1; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186; 1.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007076};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..464
FT                   /note="HD-GYP domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038345728"
FT   TRANSMEM        78..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        113..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          235..430
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   REGION          421..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  48687 MW;  C084B3A2C1E7BD0F CRC64;
     MLYLAAVLTA AAAVLLPLAA AGPEFDWPRI GLLALLHLCL ESLAQGARTP CARIWRWVRG
     RSADEAHADP RGSGFFPVLF AGVLMLPPAA AALVALPGAL LGPAAPPRGP RRLWNGAQLA
     LAAAAAAEVF RLLGGARLLL GTRFPGAALG ALAAILTFCL VNGVLVAGMI RLTRGAVGPG
     ALGALRRAAP AALLHGAGGL MIAVLWQGPY GAFAAVLGLL PLTITAWLSA QGHRERAAHR
     ATVQALVQAV EIKDAYTRGH SERVGRASVL IARQLGLAEE RVRTLHFAGT LHDVGKLAVA
     TELLRRNGPL TDAERRAVEV HPVFGHELVR QLDFLGEGRD GILHHHERMD GRGYPHGLAG
     ERIPEFARII SVADAFDSMT STRSYRRGRP VPEAVAELER CAGSQFDPVM VGALVRAVAE
     HGWQPEPPPP GGWDGEVPDI PLGVPEPARL PQQSGTGLPT GGAA
//