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Protein

Alanine racemase

Gene

alr

Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Active sitei283Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei331Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciKSET452652:G1H62-3167-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:KSE_31220Imported
OrganismiKitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)Imported
Taxonomic identifieri452652 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeKitasatospora
Proteomesi
  • UP000007076 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi452652.KSE_31220

Structurei

3D structure databases

ProteinModelPortaliE4NCK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 389Ala_racemase_CInterPro annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili17 – 37Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

E4NCK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTANTTGTP ALAQGARAEA TVDLAALRDN LAALRARTSG AELMAVVKAD
60 70 80 90 100
AYGHGALRCA REAVAAGAGW LGTATPEEAL ALRAAGIGPE QARILCWLWT
110 120 130 140 150
PGGPWARALR ESVDISISGQ WALDELLAAV RETGVPARVH LKADTGLGRN
160 170 180 190 200
GCQPHDWPDL VENAVKAQAA GLLRVVGVWS HFAAADEPGH PSIQAQLDSF
210 220 230 240 250
AQALAFAERT GVDPEVRHLA NSPATLLLPQ SHYDLVRPGL AMYGLSPVPD
260 270 280 290 300
VGAPADFGLR PVMSLAARLA LVKRVPGGHG ISYGHHYTTS GPTTLGLVPL
310 320 330 340 350
GYADGVPRHA SNTGPVQIGS SWYRVAGRVA MDQFVVDLGG DLPDVGEEVL
360 370 380 390
LFGSGERGEP TAEDWARACG TIAYEIITRI GGRVPRRYVG GSRG
Length:394
Mass (Da):41,189
Last modified:February 8, 2011 - v1
Checksum:i5CFB4BE7ED533D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA Translation: BAJ28932.1
RefSeqiWP_014136244.1, NC_016109.1

Genome annotation databases

EnsemblBacteriaiBAJ28932; BAJ28932; KSE_31220
KEGGiksk:KSE_31220
PATRICifig|452652.3.peg.3134

Similar proteinsi

Entry informationi

Entry nameiE4NCK1_KITSK
AccessioniPrimary (citable) accession number: E4NCK1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health