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Protein

Trigger factor

Gene

tig

Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation
Biological processCell cycle, Cell divisionUniRule annotation

Enzyme and pathway databases

BioCyciKSET452652:G1H62-2663-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotationImported
Ordered Locus Names:KSE_26290Imported
OrganismiKitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)Imported
Taxonomic identifieri452652 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeKitasatospora
Proteomesi
  • UP000007076 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi452652.KSE_26290

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 219PPIase FKBP-typeInterPro annotationAdd BLAST54

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DEA Bacteria
COG0544 LUCA
KOiK03545
OMAiMAMIEDR
OrthoDBiPOG091H01T7

Family and domain databases

Gene3Di1.10.3120.10, 2 hits
3.30.70.1050, 1 hit
HAMAPiMF_00303 Trigger_factor_Tig, 1 hit
InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
IPR005215 Trig_fac
IPR008880 Trigger_fac_C
IPR037041 Trigger_fac_C_sf
IPR008881 Trigger_fac_ribosome-bd_bac
IPR036611 Trigger_fac_ribosome-bd_sf
IPR027304 Trigger_fact/SurA_dom_sf
PANTHERiPTHR30560 PTHR30560, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF05698 Trigger_C, 1 hit
PF05697 Trigger_N, 1 hit
PIRSFiPIRSF003095 Trigger_factor, 1 hit
SUPFAMiSSF102735 SSF102735, 1 hit
SSF109998 SSF109998, 1 hit
TIGRFAMsiTIGR00115 tig, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

E4NB60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAVETLNP TRVRLIVEVP FEELKPSLDA AYKKINQQVT VPGFRKGKIP
60 70 80 90 100
NKVIDQRFGR GAVLEEAVND ALPRFYTQAV DEGQIDVLGQ PDITEIEGVE
110 120 130 140 150
NLADGGDLKF TAEVDVRPEV TLPEFAEIAV VVDPIEVSDE DVEKSLEQLR
160 170 180 190 200
ERFASVKDVE RAATENDIVV IDLEAKVDGE VPEDGTATGV SYEIGSGRLL
210 220 230 240 250
DGIDEAVVGL SAGESKTFTT TLKGGTQVGK DSEVTVTVTA VQEKELPELD
260 270 280 290 300
DEFAQLASEF DTLEELRADS VKRLERMKEF DQATQAQEKV LDELLSRVEL
310 320 330 340 350
DYPEKLLADE IGTRKHNLEH HQLEPMGLTL DTYLASQDKS HEDYEKETEE
360 370 380 390 400
QAKKGIKTQF VLDQIVKNEE LGVNQEELTE HLIRRAAGSG LTPDQFAQQV
410 420 430 440 450
VQGGQVQLLV GEVARGKALA LVVEAAKVTD TNGETVSFED EEETTEAAGT
460
TDAAAEATEE SAEA
Length:464
Mass (Da):50,794
Last modified:February 8, 2011 - v1
Checksum:i8DB6C0D9F64027DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA Translation: BAJ28441.1
RefSeqiWP_014135755.1, NC_016109.1

Genome annotation databases

EnsemblBacteriaiBAJ28441; BAJ28441; KSE_26290
KEGGiksk:KSE_26290
PATRICifig|452652.3.peg.2635

Similar proteinsi

Entry informationi

Entry nameiE4NB60_KITSK
AccessioniPrimary (citable) accession number: E4NB60
Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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