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E4NB60

- E4NB60_KITSK

UniProt

E4NB60 - E4NB60_KITSK

Protein

Trigger factor

Gene

tig

Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.UniRule annotation
    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    ChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation

    Enzyme and pathway databases

    BioCyciKSET452652:GJFD-2613-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotationImported
    Ordered Locus Names:KSE_26290Imported
    OrganismiKitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)Imported
    Taxonomic identifieri452652 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeKitasatospora
    ProteomesiUP000007076: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini166 – 25186PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    KOiK03545.
    OMAiFKVKVHE.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E4NB60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSAVETLNP TRVRLIVEVP FEELKPSLDA AYKKINQQVT VPGFRKGKIP    50
    NKVIDQRFGR GAVLEEAVND ALPRFYTQAV DEGQIDVLGQ PDITEIEGVE 100
    NLADGGDLKF TAEVDVRPEV TLPEFAEIAV VVDPIEVSDE DVEKSLEQLR 150
    ERFASVKDVE RAATENDIVV IDLEAKVDGE VPEDGTATGV SYEIGSGRLL 200
    DGIDEAVVGL SAGESKTFTT TLKGGTQVGK DSEVTVTVTA VQEKELPELD 250
    DEFAQLASEF DTLEELRADS VKRLERMKEF DQATQAQEKV LDELLSRVEL 300
    DYPEKLLADE IGTRKHNLEH HQLEPMGLTL DTYLASQDKS HEDYEKETEE 350
    QAKKGIKTQF VLDQIVKNEE LGVNQEELTE HLIRRAAGSG LTPDQFAQQV 400
    VQGGQVQLLV GEVARGKALA LVVEAAKVTD TNGETVSFED EEETTEAAGT 450
    TDAAAEATEE SAEA 464
    Length:464
    Mass (Da):50,794
    Last modified:February 8, 2011 - v1
    Checksum:i8DB6C0D9F64027DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010968 Genomic DNA. Translation: BAJ28441.1.
    RefSeqiWP_014135755.1. NC_016109.1.
    YP_004904397.1. NC_016109.1.

    Genome annotation databases

    EnsemblBacteriaiBAJ28441; BAJ28441; KSE_26290.
    GeneIDi11351189.
    KEGGiksk:KSE_26290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010968 Genomic DNA. Translation: BAJ28441.1 .
    RefSeqi WP_014135755.1. NC_016109.1.
    YP_004904397.1. NC_016109.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAJ28441 ; BAJ28441 ; KSE_26290 .
    GeneIDi 11351189.
    KEGGi ksk:KSE_26290.

    Phylogenomic databases

    KOi K03545.
    OMAi FKVKVHE.

    Enzyme and pathway databases

    BioCyci KSET452652:GJFD-2613-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054Imported.

    Entry informationi

    Entry nameiE4NB60_KITSK
    AccessioniPrimary (citable) accession number: E4NB60
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3