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Protein

Trigger factor

Gene

tig

Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.UniRule annotation
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein folding Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation, Isomerase, RotamaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation

Enzyme and pathway databases

BioCyciKSET452652:GJFD-2613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotationImported
Ordered Locus Names:KSE_26290Imported
OrganismiKitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)Imported
Taxonomic identifieri452652 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeKitasatospora
ProteomesiUP000007076: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 25186PPIase FKBP-typeUniRule annotationAdd
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

KOiK03545.
OMAiQRLQMQG.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E4NB60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAVETLNP TRVRLIVEVP FEELKPSLDA AYKKINQQVT VPGFRKGKIP
60 70 80 90 100
NKVIDQRFGR GAVLEEAVND ALPRFYTQAV DEGQIDVLGQ PDITEIEGVE
110 120 130 140 150
NLADGGDLKF TAEVDVRPEV TLPEFAEIAV VVDPIEVSDE DVEKSLEQLR
160 170 180 190 200
ERFASVKDVE RAATENDIVV IDLEAKVDGE VPEDGTATGV SYEIGSGRLL
210 220 230 240 250
DGIDEAVVGL SAGESKTFTT TLKGGTQVGK DSEVTVTVTA VQEKELPELD
260 270 280 290 300
DEFAQLASEF DTLEELRADS VKRLERMKEF DQATQAQEKV LDELLSRVEL
310 320 330 340 350
DYPEKLLADE IGTRKHNLEH HQLEPMGLTL DTYLASQDKS HEDYEKETEE
360 370 380 390 400
QAKKGIKTQF VLDQIVKNEE LGVNQEELTE HLIRRAAGSG LTPDQFAQQV
410 420 430 440 450
VQGGQVQLLV GEVARGKALA LVVEAAKVTD TNGETVSFED EEETTEAAGT
460
TDAAAEATEE SAEA
Length:464
Mass (Da):50,794
Last modified:February 8, 2011 - v1
Checksum:i8DB6C0D9F64027DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA. Translation: BAJ28441.1.
RefSeqiWP_014135755.1. NC_016109.1.
YP_004904397.1. NC_016109.1.

Genome annotation databases

EnsemblBacteriaiBAJ28441; BAJ28441; KSE_26290.
GeneIDi11351189.
KEGGiksk:KSE_26290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA. Translation: BAJ28441.1.
RefSeqiWP_014135755.1. NC_016109.1.
YP_004904397.1. NC_016109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAJ28441; BAJ28441; KSE_26290.
GeneIDi11351189.
KEGGiksk:KSE_26290.

Phylogenomic databases

KOiK03545.
OMAiQRLQMQG.

Enzyme and pathway databases

BioCyciKSET452652:GJFD-2613-MONOMER.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054Imported.

Entry informationi

Entry nameiE4NB60_KITSK
AccessioniPrimary (citable) accession number: E4NB60
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.