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Protein

Glutamate decarboxylase

Gene

KSE_25120

Organism
Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciKSET452652:GJFD-2495-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:KSE_25120Imported
OrganismiKitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae)Imported
Taxonomic identifieri452652 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeKitasatospora
ProteomesiUP000007076 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiFVGTWMD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

E4NAU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHKGQGRG EDERRLPVSP LHVLTDPLGS MQLAPPLHRL PRVPIPPPVA
60 70 80 90 100
YQLIHDELML DGNARLNLAT FVTTQMDEHA DRLMAECRDK NMIDKDEYPQ
110 120 130 140 150
TAELERRCVA ILADLWHAPD PAAAVGCSTT GSSEACMLAG MALKRRWTAR
160 170 180 190 200
NADRYAAGAR PNLVMGVNVQ VCWEKFCNFW EVEARLVPME GERFHLSAEE
210 220 230 240 250
AVARCDENTI GVVGILGSTF DGSYEPIAEI CAALDAFQER TGLDVPVHVD
260 270 280 290 300
GASGGMVAPF LDPELKWDFR LPRVASINAS GHKYGLVYPG VGWALWRDGE
310 320 330 340 350
ALPEELVFKV NYLGGEMPTF ALNFSRPGAE VVAQYYAFLR LGFGGYHAIQ
360 370 380 390 400
QACRDVAEYL AAEIAKCGPF RLITKGDQLP VFAFTTVDGC PFDVFDVSRR
410 420 430 440 450
LRERGWQVPA YTFPEGRTDL AVLRVVCRNG FSRDLADLLL ADLRRLLPEL
460 470
ERQPAPLSEL GMPQRSGFHH
Length:470
Mass (Da):52,116
Last modified:February 8, 2011 - v1
Checksum:iB6550DCC020918C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA. Translation: BAJ28326.1.
RefSeqiWP_014135640.1. NC_016109.1.
YP_004904282.1. NC_016109.1.

Genome annotation databases

EnsemblBacteriaiBAJ28326; BAJ28326; KSE_25120.
KEGGiksk:KSE_25120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010968 Genomic DNA. Translation: BAJ28326.1.
RefSeqiWP_014135640.1. NC_016109.1.
YP_004904282.1. NC_016109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAJ28326; BAJ28326; KSE_25120.
KEGGiksk:KSE_25120.

Phylogenomic databases

KOiK01580.
OMAiFVGTWMD.

Enzyme and pathway databases

BioCyciKSET452652:GJFD-2495-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054Imported.

Entry informationi

Entry nameiE4NAU5_KITSK
AccessioniPrimary (citable) accession number: E4NAU5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: April 29, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.