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Protein
Submitted name:

Estrogen receptor alpha

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: InterPro
  3. estrogen receptor activity Source: InterPro
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  5. steroid binding Source: InterPro

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. antral ovarian follicle growth Source: Ensembl
  3. cellular response to estrogen stimulus Source: Ensembl
  4. epithelial cell development Source: Ensembl
  5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  6. male gonad development Source: Ensembl
  7. mammary gland alveolus development Source: Ensembl
  8. mammary gland branching involved in pregnancy Source: Ensembl
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  12. prostate epithelial cord elongation Source: Ensembl
  13. regulation of apoptotic process Source: Ensembl
  14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  15. uterus development Source: Ensembl
  16. vagina development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor alphaImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE3WH18.
ExpressionAtlasiE3WH18. baseline and differential.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR001292. Oestr_rcpt.
[Graphical view]
PfamiPF02159. Oest_recep. 1 hit.
[Graphical view]
PRINTSiPR00543. OESTROGENR.

Sequencei

Sequence statusi: Fragment.

E3WH18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHTKASGM ALLHQIQGNE LEPLNRPQLK IPLERPLGEV YLDSSKPAVY
60 70 80 90 100
NYPEGAAYEF NAAAAANAQV YGQTGLPYGP GSEAAAFGSN GLGGFPPLNS
110 120 130 140 150
VSPSPLMLLH PPPQLSPFLQ PHGQQVPYYL ENEPSGYTVR EAGPPAFYRP
160 170 180 190
NSDNRRQGGR ERLASTNDKG SMAMESAKET RYCAVCNDYA
Length:190
Mass (Da):20,511
Last modified:February 8, 2011 - v1
Checksum:i93EC201CECE902B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei190 – 1901Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB588629 mRNA. Translation: BAJ41265.1.
UniGeneiHs.208124.
Hs.744830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB588629 mRNA. Translation: BAJ41265.1.
UniGeneiHs.208124.
Hs.744830.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiE3WH18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiESR1. human.
NextBioi35497344.

Gene expression databases

BgeeiE3WH18.
ExpressionAtlasiE3WH18. baseline and differential.

Family and domain databases

InterProiIPR001292. Oestr_rcpt.
[Graphical view]
PfamiPF02159. Oest_recep. 1 hit.
[Graphical view]
PRINTSiPR00543. OESTROGENR.
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel splicing events and post-transcriptional regulation of human estrogen receptor ? F isoforms."
    Kobayashi M., Ishii H., Sakuma Y.
    Mol. Cell. Endocrinol. 333:55-61(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.

Entry informationi

Entry nameiE3WH18_HUMAN
AccessioniPrimary (citable) accession number: E3WH18
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.