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E3WH18

- E3WH18_HUMAN

UniProt

E3WH18 - E3WH18_HUMAN

Protein
Submitted name:

Estrogen receptor alpha

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: InterPro
    3. estrogen receptor activity Source: InterPro
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    5. steroid binding Source: InterPro

    GO - Biological processi

    1. androgen metabolic process Source: Ensembl
    2. antral ovarian follicle growth Source: Ensembl
    3. cellular response to estrogen stimulus Source: Ensembl
    4. epithelial cell development Source: Ensembl
    5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
    6. male gonad development Source: Ensembl
    7. mammary gland alveolus development Source: Ensembl
    8. mammary gland branching involved in pregnancy Source: Ensembl
    9. positive regulation of fibroblast proliferation Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    12. prostate epithelial cord elongation Source: Ensembl
    13. regulation of apoptotic process Source: Ensembl
    14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    15. uterus development Source: Ensembl
    16. vagina development Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Estrogen receptor alphaImported
    Gene namesi
    Name:ESR1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiE3WH18.
    BgeeiE3WH18.

    Family & Domainsi

    Family and domain databases

    InterProiIPR001292. Oestr_rcpt.
    [Graphical view]
    PfamiPF02159. Oest_recep. 1 hit.
    [Graphical view]
    PRINTSiPR00543. OESTROGENR.

    Sequencei

    Sequence statusi: Fragment.

    E3WH18-1 [UniParc]FASTAAdd to Basket

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    MTLHTKASGM ALLHQIQGNE LEPLNRPQLK IPLERPLGEV YLDSSKPAVY    50
    NYPEGAAYEF NAAAAANAQV YGQTGLPYGP GSEAAAFGSN GLGGFPPLNS 100
    VSPSPLMLLH PPPQLSPFLQ PHGQQVPYYL ENEPSGYTVR EAGPPAFYRP 150
    NSDNRRQGGR ERLASTNDKG SMAMESAKET RYCAVCNDYA 190
    Length:190
    Mass (Da):20,511
    Last modified:February 8, 2011 - v1
    Checksum:i93EC201CECE902B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei190 – 1901Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB588629 mRNA. Translation: BAJ41265.1.
    UniGeneiHs.208124.
    Hs.744830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB588629 mRNA. Translation: BAJ41265.1 .
    UniGenei Hs.208124.
    Hs.744830.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi ESR1. human.
    NextBioi 35497344.

    Gene expression databases

    ArrayExpressi E3WH18.
    Bgeei E3WH18.

    Family and domain databases

    InterProi IPR001292. Oestr_rcpt.
    [Graphical view ]
    Pfami PF02159. Oest_recep. 1 hit.
    [Graphical view ]
    PRINTSi PR00543. OESTROGENR.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel splicing events and post-transcriptional regulation of human estrogen receptor ? F isoforms."
      Kobayashi M., Ishii H., Sakuma Y.
      Mol. Cell. Endocrinol. 333:55-61(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: OvaryImported.

    Entry informationi

    Entry nameiE3WH18_HUMAN
    AccessioniPrimary (citable) accession number: E3WH18
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 8, 2011
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.