ID   E3WET6_ORYLA            Unreviewed;       107 AA.
AC   E3WET6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Cocaine-and amphetamine-regulated transcript ch4 {ECO:0000313|EMBL:BAJ39822.1};
GN   Name=cart ch4 {ECO:0000313|EMBL:BAJ39822.1};
GN   Synonyms=LOC100533498 {ECO:0000313|Ensembl:ENSORLP00000016583.1};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|EMBL:BAJ39822.1};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000016583.1, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016583.1,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|EMBL:BAJ39822.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21078323; DOI=10.1016/j.ygcen.2010.11.005;
RA   Murashita K., Kurokawa T.;
RT   "Multiple cocaine- and amphetamine-regulated transcript (CART) genes in
RT   medaka, Oryzias latipes: cloning, tissue distribution and effect of
RT   starvation.";
RL   Gen. Comp. Endocrinol. 170:494-500(2011).
RN   [3] {ECO:0000313|Ensembl:ENSORLP00000016583.1}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000016583.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the CART family.
CC       {ECO:0000256|ARBA:ARBA00005294}.
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DR   EMBL; AB568293; BAJ39822.1; -; mRNA.
DR   RefSeq; NP_001191709.1; NM_001204780.1.
DR   STRING; 8090.ENSORLP00000016583; -.
DR   Ensembl; ENSORLT00000016584.2; ENSORLP00000016583.1; ENSORLG00000013234.2.
DR   GeneID; 100533498; -.
DR   KEGG; ola:100533498; -.
DR   eggNOG; ENOG502S592; Eukaryota.
DR   GeneTree; ENSGT00390000018319; -.
DR   HOGENOM; CLU_157363_0_0_1; -.
DR   OMA; NFTVLKC; -.
DR   OrthoDB; 3971848at2759; -.
DR   TreeFam; TF332948; -.
DR   Proteomes; UP000001038; Chromosome 4.
DR   Bgee; ENSORLG00000013234; Expressed in brain and 2 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0008343; P:adult feeding behavior; IEA:InterPro.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0032099; P:negative regulation of appetite; IEA:InterPro.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:InterPro.
DR   Gene3D; 4.10.40.30; CART, C-terminal domain; 1.
DR   InterPro; IPR009106; CART.
DR   InterPro; IPR036722; CART_C_sf.
DR   PANTHER; PTHR16655; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN; 1.
DR   PANTHER; PTHR16655:SF4; COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN; 1.
DR   Pfam; PF06373; CART; 1.
DR   SUPFAM; SSF64546; Satiety factor CART (cocaine and amphetamine regulated transcript); 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..107
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015090245"
SQ   SEQUENCE   107 AA;  12069 MW;  D8099066F4D7DD6A CRC64;
     MVSSRMLLLS ASCWLLVALG SCEEQMEERS PEYEAFKTQE EKELIEALQE VLEKLRNKQL
     PSSEKKLGWL PPCNTSEQCA VRKGARVGKL CGCPRGMECD FSILKCL
//