Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cellular tumor antigen p53

Gene

TP53

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. chromatin binding Source: Ensembl
  3. copper ion binding Source: Ensembl
  4. histone deacetylase regulator activity Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. B cell lineage commitment Source: Ensembl
  2. cellular response to drug Source: Ensembl
  3. cellular response to glucose starvation Source: Ensembl
  4. cellular response to hypoxia Source: Ensembl
  5. cellular response to ionizing radiation Source: Ensembl
  6. cellular response to UV Source: Ensembl
  7. cerebellum development Source: Ensembl
  8. chromatin assembly Source: Ensembl
  9. determination of adult lifespan Source: Ensembl
  10. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
  11. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  12. DNA strand renaturation Source: Ensembl
  13. double-strand break repair Source: Ensembl
  14. embryonic organ development Source: Ensembl
  15. ER overload response Source: Ensembl
  16. gastrulation Source: Ensembl
  17. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  18. in utero embryonic development Source: Ensembl
  19. mitochondrial DNA repair Source: Ensembl
  20. mitotic cell cycle arrest Source: Ensembl
  21. multicellular organism growth Source: Ensembl
  22. necroptotic process Source: Ensembl
  23. negative regulation of apoptotic process Source: Ensembl
  24. negative regulation of cell growth Source: Ensembl
  25. negative regulation of DNA replication Source: Ensembl
  26. negative regulation of fibroblast proliferation Source: Ensembl
  27. negative regulation of macromitophagy Source: Ensembl
  28. negative regulation of neuroblast proliferation Source: Ensembl
  29. negative regulation of reactive oxygen species metabolic process Source: Ensembl
  30. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  31. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  32. neuron apoptotic process Source: Ensembl
  33. nucleotide-excision repair Source: Ensembl
  34. oligodendrocyte apoptotic process Source: Ensembl
  35. oxidative stress-induced premature senescence Source: Ensembl
  36. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  37. positive regulation of cell aging Source: Ensembl
  38. positive regulation of histone deacetylation Source: Ensembl
  39. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  40. positive regulation of mitochondrial membrane permeability Source: Ensembl
  41. positive regulation of neuron apoptotic process Source: Ensembl
  42. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  43. positive regulation of protein oligomerization Source: Ensembl
  44. positive regulation of reactive oxygen species metabolic process Source: Ensembl
  45. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  46. positive regulation of thymocyte apoptotic process Source: Ensembl
  47. protein import into nucleus, translocation Source: Ensembl
  48. protein tetramerization Source: InterPro
  49. Ras protein signal transduction Source: Ensembl
  50. regulation of fibroblast apoptotic process Source: Ensembl
  51. regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  52. regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
  53. regulation of tissue remodeling Source: Ensembl
  54. release of cytochrome c from mitochondria Source: Ensembl
  55. replicative senescence Source: Ensembl
  56. response to antibiotic Source: Ensembl
  57. response to gamma radiation Source: Ensembl
  58. response to ischemia Source: Ensembl
  59. response to salt stress Source: Ensembl
  60. response to X-ray Source: Ensembl
  61. rRNA transcription Source: Ensembl
  62. somitogenesis Source: Ensembl
  63. T cell differentiation in thymus Source: Ensembl
  64. T cell lineage commitment Source: Ensembl
  65. T cell proliferation involved in immune response Source: Ensembl
  66. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

ApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cellular tumor antigen p53Imported
Submitted name:
Cellular tumor antigen p53 isoform aImported
Submitted name:
Tumor suppressor p53Imported
Gene namesi
Name:TP53Imported
ORF Names:EGK_08142Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrial matrix Source: Ensembl
  3. nuclear chromatin Source: Ensembl
  4. nuclear matrix Source: Ensembl
  5. nucleolus Source: Ensembl
  6. PML body Source: Ensembl
  7. replication fork Source: Ensembl
  8. transcription factor TFIID complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressorUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiE3U906. baseline.

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE3U906.
SMRiE3U906. Positions 94-297, 325-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

KOiK04451.
OMAiSQKTYPG.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3U906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPQSDPSI EPPLSQETFS DLWKLLPENN VLSPLPSQAV DDLMLSPDDL
60 70 80 90 100
AQWLTEDPGP DEAPRMSEAA PPMAPTPAAP TPAAPAPAPS WPLSSSVPSQ
110 120 130 140 150
KTYHGSYGFR LGFLHSGTAK SVTCTYSPDL NKMFCQLAKT CPVQLWVDST
160 170 180 190 200
PPPGSRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN
210 220 230 240 250
LRVEYSDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP
260 270 280 290 300
ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENFR KKGEPCHQLP
310 320 330 340 350
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL
360 370 380 390
KDAQAGKEPA GSRAHSSHLK SKKGQSTSRH KKFMFKTEGP DSD
Length:393
Mass (Da):43,655
Last modified:January 11, 2011 - v1
Checksum:iE212E5E4FE650103
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM104190 mRNA. Translation: ADO78765.1.
HM104191 mRNA. Translation: ADO78766.1.
JU472158 mRNA. Translation: AFH28962.1.
JU472159 mRNA. Translation: AFH28963.1.
JU472160 mRNA. Translation: AFH28964.1.
JV044751 mRNA. Translation: AFI34822.1.
CM001268 Genomic DNA. Translation: EHH24484.1.
RefSeqiNP_001040616.1. NM_001047151.2.
UniGeneiMmu.3286.

Genome annotation databases

GeneIDi716170.
KEGGimcc:716170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM104190 mRNA. Translation: ADO78765.1.
HM104191 mRNA. Translation: ADO78766.1.
JU472158 mRNA. Translation: AFH28962.1.
JU472159 mRNA. Translation: AFH28963.1.
JU472160 mRNA. Translation: AFH28964.1.
JV044751 mRNA. Translation: AFI34822.1.
CM001268 Genomic DNA. Translation: EHH24484.1.
RefSeqiNP_001040616.1. NM_001047151.2.
UniGeneiMmu.3286.

3D structure databases

ProteinModelPortaliE3U906.
SMRiE3U906. Positions 94-297, 325-356.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi716170.
KEGGimcc:716170.

Organism-specific databases

CTDi7157.

Phylogenomic databases

KOiK04451.
OMAiSQKTYPG.

Miscellaneous databases

NextBioi19971313.

Gene expression databases

ExpressionAtlasiE3U906. baseline.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CR-5Imported.
  2. "Elevated Rate of Fixation of Endogenous Retroviral Elements in Haplorhini TRIM5 and TRIM22 Genomic Sequences: Impact on Transcriptional Regulation."
    Diehl W.E., Johnson W.E., Hunter E.
    PLoS ONE 8:E58532-E58532(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported and ThymusImported.

Entry informationi

Entry nameiE3U906_MACMU
AccessioniPrimary (citable) accession number: E3U906
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.