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E3U906

- E3U906_MACMU

UniProt

E3U906 - E3U906_MACMU

Protein

Cellular tumor antigen p53

Gene

TP53

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation
    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity.

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit By similarity.

    GO - Molecular functioni

    1. ATP binding Source: Ensembl
    2. chromatin binding Source: Ensembl
    3. copper ion binding Source: Ensembl
    4. histone deacetylase regulator activity Source: Ensembl
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    6. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. B cell lineage commitment Source: Ensembl
    2. cellular response to drug Source: Ensembl
    3. cellular response to glucose starvation Source: Ensembl
    4. cellular response to hypoxia Source: Ensembl
    5. cellular response to ionizing radiation Source: Ensembl
    6. cellular response to UV Source: Ensembl
    7. central nervous system development Source: Ensembl
    8. chromatin assembly Source: Ensembl
    9. determination of adult lifespan Source: Ensembl
    10. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
    11. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
    12. DNA strand renaturation Source: Ensembl
    13. double-strand break repair Source: Ensembl
    14. embryonic organ development Source: Ensembl
    15. ER overload response Source: Ensembl
    16. gastrulation Source: Ensembl
    17. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    18. in utero embryonic development Source: Ensembl
    19. mitotic cell cycle arrest Source: Ensembl
    20. multicellular organism growth Source: Ensembl
    21. negative regulation of apoptotic process Source: Ensembl
    22. negative regulation of cell growth Source: Ensembl
    23. negative regulation of DNA replication Source: Ensembl
    24. negative regulation of fibroblast proliferation Source: Ensembl
    25. negative regulation of macromitophagy Source: Ensembl
    26. negative regulation of neuroblast proliferation Source: Ensembl
    27. negative regulation of reactive oxygen species metabolic process Source: Ensembl
    28. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    29. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    30. neuron apoptotic process Source: Ensembl
    31. nucleotide-excision repair Source: Ensembl
    32. oligodendrocyte apoptotic process Source: Ensembl
    33. oxidative stress-induced premature senescence Source: Ensembl
    34. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
    35. positive regulation of cell aging Source: Ensembl
    36. positive regulation of histone deacetylation Source: Ensembl
    37. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    38. positive regulation of neuron apoptotic process Source: Ensembl
    39. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    40. positive regulation of protein oligomerization Source: Ensembl
    41. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    42. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
    43. positive regulation of thymocyte apoptotic process Source: Ensembl
    44. protein import into nucleus, translocation Source: Ensembl
    45. protein tetramerization Source: InterPro
    46. Ras protein signal transduction Source: Ensembl
    47. regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
    48. regulation of tissue remodeling Source: Ensembl
    49. release of cytochrome c from mitochondria Source: Ensembl
    50. replicative senescence Source: Ensembl
    51. response to antibiotic Source: Ensembl
    52. response to gamma radiation Source: Ensembl
    53. response to ischemia Source: Ensembl
    54. response to salt stress Source: Ensembl
    55. response to X-ray Source: Ensembl
    56. rRNA transcription Source: Ensembl
    57. somitogenesis Source: Ensembl
    58. T cell differentiation in thymus Source: Ensembl
    59. T cell lineage commitment Source: Ensembl
    60. T cell proliferation involved in immune response Source: Ensembl
    61. transforming growth factor beta receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    ActivatorUniRule annotation

    Keywords - Biological processi

    ApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cellular tumor antigen p53UniRule annotation
    Gene namesi
    Name:TP53Imported
    ORF Names:EGK_08142Imported
    OrganismiMacaca mulatta (Rhesus macaque)Imported
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation
    Cytoplasm. Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. nuclear chromatin Source: Ensembl
    4. nuclear matrix Source: Ensembl
    5. nucleolus Source: Ensembl
    6. PML body Source: Ensembl
    7. replication fork Source: Ensembl
    8. transcription factor TFIID complex Source: Ensembl

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressorUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Interactioni

    Subunit structurei

    Binds DNA as a homotetramer.UniRule annotation
    Binds DNA as a homotetramer By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliE3U906.
    SMRiE3U906. Positions 94-297, 325-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the p53 family.UniRule annotation

    Phylogenomic databases

    KOiK04451.
    OMAiSFMCNSS.

    Family and domain databases

    Gene3Di2.60.40.720. 1 hit.
    4.10.170.10. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR012346. p53/RUNT-type_TF_DNA-bd.
    IPR011615. p53_DNA-bd.
    IPR010991. p53_tetrameristn.
    IPR013872. p53_transactivation_domain.
    IPR002117. p53_tumour_suppressor.
    [Graphical view]
    PANTHERiPTHR11447. PTHR11447. 1 hit.
    PfamiPF00870. P53. 1 hit.
    PF08563. P53_TAD. 1 hit.
    PF07710. P53_tetramer. 1 hit.
    [Graphical view]
    PRINTSiPR00386. P53SUPPRESSR.
    SUPFAMiSSF47719. SSF47719. 1 hit.
    SSF49417. SSF49417. 1 hit.
    PROSITEiPS00348. P53. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E3U906-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEPQSDPSI EPPLSQETFS DLWKLLPENN VLSPLPSQAV DDLMLSPDDL    50
    AQWLTEDPGP DEAPRMSEAA PPMAPTPAAP TPAAPAPAPS WPLSSSVPSQ 100
    KTYHGSYGFR LGFLHSGTAK SVTCTYSPDL NKMFCQLAKT CPVQLWVDST 150
    PPPGSRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN 200
    LRVEYSDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP 250
    ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENFR KKGEPCHQLP 300
    PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL 350
    KDAQAGKEPA GSRAHSSHLK SKKGQSTSRH KKFMFKTEGP DSD 393
    Length:393
    Mass (Da):43,655
    Last modified:January 11, 2011 - v1
    Checksum:iE212E5E4FE650103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM104190 mRNA. Translation: ADO78765.1.
    HM104191 mRNA. Translation: ADO78766.1.
    JU472158 mRNA. Translation: AFH28962.1.
    JU472159 mRNA. Translation: AFH28963.1.
    JU472160 mRNA. Translation: AFH28964.1.
    JV044751 mRNA. Translation: AFI34822.1.
    CM001268 Genomic DNA. Translation: EHH24484.1.
    RefSeqiNP_001040616.1. NM_001047151.2.
    UniGeneiMmu.3286.

    Genome annotation databases

    GeneIDi716170.
    KEGGimcc:716170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM104190 mRNA. Translation: ADO78765.1 .
    HM104191 mRNA. Translation: ADO78766.1 .
    JU472158 mRNA. Translation: AFH28962.1 .
    JU472159 mRNA. Translation: AFH28963.1 .
    JU472160 mRNA. Translation: AFH28964.1 .
    JV044751 mRNA. Translation: AFI34822.1 .
    CM001268 Genomic DNA. Translation: EHH24484.1 .
    RefSeqi NP_001040616.1. NM_001047151.2.
    UniGenei Mmu.3286.

    3D structure databases

    ProteinModelPortali E3U906.
    SMRi E3U906. Positions 94-297, 325-356.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 716170.
    KEGGi mcc:716170.

    Organism-specific databases

    CTDi 7157.

    Phylogenomic databases

    KOi K04451.
    OMAi SFMCNSS.

    Miscellaneous databases

    NextBioi 19971313.

    Family and domain databases

    Gene3Di 2.60.40.720. 1 hit.
    4.10.170.10. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR012346. p53/RUNT-type_TF_DNA-bd.
    IPR011615. p53_DNA-bd.
    IPR010991. p53_tetrameristn.
    IPR013872. p53_transactivation_domain.
    IPR002117. p53_tumour_suppressor.
    [Graphical view ]
    PANTHERi PTHR11447. PTHR11447. 1 hit.
    Pfami PF00870. P53. 1 hit.
    PF08563. P53_TAD. 1 hit.
    PF07710. P53_tetramer. 1 hit.
    [Graphical view ]
    PRINTSi PR00386. P53SUPPRESSR.
    SUPFAMi SSF47719. SSF47719. 1 hit.
    SSF49417. SSF49417. 1 hit.
    PROSITEi PS00348. P53. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CR-5Imported.
    2. "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
      Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
      Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ThymusImported.
    3. "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
      Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
      Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TestisImported.
    4. "Elevated Rate of Fixation of Endogenous Retroviral Elements in Haplorhini TRIM5 and TRIM22 Genomic Sequences: Impact on Transcriptional Regulation."
      Diehl W.E., Johnson W.E., Hunter E.
      PLoS ONE 8:E58532-E58532(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiE3U906_MACMU
    AccessioniPrimary (citable) accession number: E3U906
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)