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E3U906

- E3U906_MACMU

UniProt

E3U906 - E3U906_MACMU

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Protein

Cellular tumor antigen p53

Gene
TP53, EGK_08142
Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. chromatin binding Source: Ensembl
  3. copper ion binding Source: Ensembl
  4. histone deacetylase regulator activity Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. B cell lineage commitment Source: Ensembl
  2. cellular response to drug Source: Ensembl
  3. cellular response to glucose starvation Source: Ensembl
  4. cellular response to hypoxia Source: Ensembl
  5. cellular response to ionizing radiation Source: Ensembl
  6. cellular response to UV Source: Ensembl
  7. central nervous system development Source: Ensembl
  8. chromatin assembly Source: Ensembl
  9. determination of adult lifespan Source: Ensembl
  10. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
  11. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  12. DNA strand renaturation Source: Ensembl
  13. double-strand break repair Source: Ensembl
  14. embryonic organ development Source: Ensembl
  15. ER overload response Source: Ensembl
  16. gastrulation Source: Ensembl
  17. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  18. in utero embryonic development Source: Ensembl
  19. mitotic cell cycle arrest Source: Ensembl
  20. multicellular organism growth Source: Ensembl
  21. negative regulation of apoptotic process Source: Ensembl
  22. negative regulation of cell growth Source: Ensembl
  23. negative regulation of DNA replication Source: Ensembl
  24. negative regulation of fibroblast proliferation Source: Ensembl
  25. negative regulation of macromitophagy Source: Ensembl
  26. negative regulation of neuroblast proliferation Source: Ensembl
  27. negative regulation of reactive oxygen species metabolic process Source: Ensembl
  28. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  29. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  30. neuron apoptotic process Source: Ensembl
  31. nucleotide-excision repair Source: Ensembl
  32. oligodendrocyte apoptotic process Source: Ensembl
  33. oxidative stress-induced premature senescence Source: Ensembl
  34. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  35. positive regulation of cell aging Source: Ensembl
  36. positive regulation of histone deacetylation Source: Ensembl
  37. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  38. positive regulation of neuron apoptotic process Source: Ensembl
  39. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  40. positive regulation of protein oligomerization Source: Ensembl
  41. positive regulation of reactive oxygen species metabolic process Source: Ensembl
  42. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  43. positive regulation of thymocyte apoptotic process Source: Ensembl
  44. protein import into nucleus, translocation Source: Ensembl
  45. protein tetramerization Source: InterPro
  46. Ras protein signal transduction Source: Ensembl
  47. regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
  48. regulation of tissue remodeling Source: Ensembl
  49. release of cytochrome c from mitochondria Source: Ensembl
  50. replicative senescence Source: Ensembl
  51. response to antibiotic Source: Ensembl
  52. response to gamma radiation Source: Ensembl
  53. response to ischemia Source: Ensembl
  54. response to salt stress Source: Ensembl
  55. response to X-ray Source: Ensembl
  56. rRNA transcription Source: Ensembl
  57. somitogenesis Source: Ensembl
  58. T cell differentiation in thymus Source: Ensembl
  59. T cell lineage commitment Source: Ensembl
  60. T cell proliferation involved in immune response Source: Ensembl
  61. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

ApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
Gene namesi
Name:TP53Imported
ORF Names:EGK_08142Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Cytoplasm. Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nuclear chromatin Source: Ensembl
  4. nuclear matrix Source: Ensembl
  5. nucleolus Source: Ensembl
  6. PML body Source: Ensembl
  7. replication fork Source: Ensembl
  8. transcription factor TFIID complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressorUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Binds DNA as a homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliE3U906.
SMRiE3U906. Positions 94-297, 325-356.

Family & Domainsi

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

KOiK04451.
OMAiSFMCNSS.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E3U906-1 [UniParc]FASTAAdd to Basket

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MEEPQSDPSI EPPLSQETFS DLWKLLPENN VLSPLPSQAV DDLMLSPDDL    50
AQWLTEDPGP DEAPRMSEAA PPMAPTPAAP TPAAPAPAPS WPLSSSVPSQ 100
KTYHGSYGFR LGFLHSGTAK SVTCTYSPDL NKMFCQLAKT CPVQLWVDST 150
PPPGSRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN 200
LRVEYSDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP 250
ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENFR KKGEPCHQLP 300
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL 350
KDAQAGKEPA GSRAHSSHLK SKKGQSTSRH KKFMFKTEGP DSD 393
Length:393
Mass (Da):43,655
Last modified:January 11, 2011 - v1
Checksum:iE212E5E4FE650103
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM104190 mRNA. Translation: ADO78765.1.
HM104191 mRNA. Translation: ADO78766.1.
JU472158 mRNA. Translation: AFH28962.1.
JU472159 mRNA. Translation: AFH28963.1.
JU472160 mRNA. Translation: AFH28964.1.
JV044751 mRNA. Translation: AFI34822.1.
CM001268 Genomic DNA. Translation: EHH24484.1.
RefSeqiNP_001040616.1. NM_001047151.2.
UniGeneiMmu.3286.

Genome annotation databases

GeneIDi716170.
KEGGimcc:716170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM104190 mRNA. Translation: ADO78765.1 .
HM104191 mRNA. Translation: ADO78766.1 .
JU472158 mRNA. Translation: AFH28962.1 .
JU472159 mRNA. Translation: AFH28963.1 .
JU472160 mRNA. Translation: AFH28964.1 .
JV044751 mRNA. Translation: AFI34822.1 .
CM001268 Genomic DNA. Translation: EHH24484.1 .
RefSeqi NP_001040616.1. NM_001047151.2.
UniGenei Mmu.3286.

3D structure databases

ProteinModelPortali E3U906.
SMRi E3U906. Positions 94-297, 325-356.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 716170.
KEGGi mcc:716170.

Organism-specific databases

CTDi 7157.

Phylogenomic databases

KOi K04451.
OMAi SFMCNSS.

Miscellaneous databases

NextBioi 19971313.

Family and domain databases

Gene3Di 2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view ]
PANTHERi PTHR11447. PTHR11447. 1 hit.
Pfami PF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view ]
PRINTSi PR00386. P53SUPPRESSR.
SUPFAMi SSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEi PS00348. P53. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CR-5Imported.
  2. "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
    Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.
  3. "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
    Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  4. "Elevated Rate of Fixation of Endogenous Retroviral Elements in Haplorhini TRIM5 and TRIM22 Genomic Sequences: Impact on Transcriptional Regulation."
    Diehl W.E., Johnson W.E., Hunter E.
    PLoS ONE 8:E58532-E58532(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE3U906_MACMU
AccessioniPrimary (citable) accession number: E3U906
Entry historyi
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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