Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E3U906 (E3U906_MACMU) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Cellular tumor antigen p53 RuleBase RU003304
Gene names
Name:TP53 EMBL ADO78765.1
ORF Names:EGK_08142 EMBL EHH24484.1
OrganismMacaca mulatta (Rhesus macaque) EMBL ADO78765.1
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Binds DNA as a homotetramer By similarity.

Subcellular location

Cytoplasm. Nucleus By similarity.

Sequence similarities

Belongs to the p53 family. RuleBase RU003401

Ontologies

Keywords
   Biological processApoptosis RuleBase RU003304
Cell cycle RuleBase RU003304
Transcription
Transcription regulation SAAS SAAS012346 RuleBase RU003304
   Cellular componentCytoplasm RuleBase RU003304
Nucleus SAAS SAAS012346 RuleBase RU003304
   DiseaseTumor suppressor RuleBase RU003304
   LigandDNA-binding RuleBase RU003304
Metal-binding RuleBase RU003304
Zinc RuleBase RU003304
   Molecular functionActivator RuleBase RU003304
   PTMPhosphoprotein RuleBase RU003304
Gene Ontology (GO)
   Biological_processB cell lineage commitment

Inferred from electronic annotation. Source: Ensembl

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

Inferred from electronic annotation. Source: Ensembl

DNA strand renaturation

Inferred from electronic annotation. Source: Ensembl

ER overload response

Inferred from electronic annotation. Source: Ensembl

Ras protein signal transduction

Inferred from electronic annotation. Source: Ensembl

T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

T cell lineage commitment

Inferred from electronic annotation. Source: Ensembl

T cell proliferation involved in immune response

Inferred from electronic annotation. Source: Ensembl

cellular response to UV

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

cellular response to glucose starvation

Inferred from electronic annotation. Source: Ensembl

cellular response to hypoxia

Inferred from electronic annotation. Source: Ensembl

cellular response to ionizing radiation

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Inferred from electronic annotation. Source: Ensembl

chromatin assembly

Inferred from electronic annotation. Source: Ensembl

determination of adult lifespan

Inferred from electronic annotation. Source: Ensembl

double-strand break repair

Inferred from electronic annotation. Source: Ensembl

embryonic organ development

Inferred from electronic annotation. Source: Ensembl

gastrulation

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

mitotic cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of macromitophagy

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuroblast proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair

Inferred from electronic annotation. Source: Ensembl

oligodendrocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

oxidative stress-induced premature senescence

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell aging

Inferred from electronic annotation. Source: Ensembl

positive regulation of histone deacetylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of intrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein oligomerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

positive regulation of thymocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

protein tetramerization

Inferred from electronic annotation. Source: InterPro

rRNA transcription

Inferred from electronic annotation. Source: Ensembl

regulation of mitochondrial membrane permeability involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

regulation of tissue remodeling

Inferred from electronic annotation. Source: Ensembl

release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

replicative senescence

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from electronic annotation. Source: Ensembl

response to antibiotic

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

response to ischemia

Inferred from electronic annotation. Source: Ensembl

response to salt stress

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentPML body

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from electronic annotation. Source: Ensembl

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nuclear matrix

Inferred from electronic annotation. Source: Ensembl

nucleolus

Inferred from electronic annotation. Source: Ensembl

replication fork

Inferred from electronic annotation. Source: Ensembl

transcription factor TFIID complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

chromatin binding

Inferred from electronic annotation. Source: Ensembl

copper ion binding

Inferred from electronic annotation. Source: Ensembl

histone deacetylase regulator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E3U906 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: E212E5E4FE650103

FASTA39343,655
        10         20         30         40         50         60 
MEEPQSDPSI EPPLSQETFS DLWKLLPENN VLSPLPSQAV DDLMLSPDDL AQWLTEDPGP 

        70         80         90        100        110        120 
DEAPRMSEAA PPMAPTPAAP TPAAPAPAPS WPLSSSVPSQ KTYHGSYGFR LGFLHSGTAK 

       130        140        150        160        170        180 
SVTCTYSPDL NKMFCQLAKT CPVQLWVDST PPPGSRVRAM AIYKQSQHMT EVVRRCPHHE 

       190        200        210        220        230        240 
RCSDSDGLAP PQHLIRVEGN LRVEYSDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 

       250        260        270        280        290        300 
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENFR KKGEPCHQLP 

       310        320        330        340        350        360 
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPA 

       370        380        390 
GSRAHSSHLK SKKGQSTSRH KKFMFKTEGP DSD 

« Hide

References

[1]"Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques."
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z., Thompson J.R., Meng Y., Bai Y. expand/collapse author list , Wang J., Zhuo M., Wang T., Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.
Nat. Biotechnol. 29:1019-1023(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CR-5 EMBL EHH24484.1.
[2]"De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Thymus EMBL AFH28962.1.
[3]"De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Testis EMBL AFI34822.1.
[4]"Elevated Rate of Fixation of Endogenous Retroviral Elements in Haplorhini TRIM5 and TRIM22 Genomic Sequences: Impact on Transcriptional Regulation."
Diehl W.E., Johnson W.E., Hunter E.
PLoS ONE 8:E58532-E58532(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HM104190 mRNA. Translation: ADO78765.1.
HM104191 mRNA. Translation: ADO78766.1.
JU472158 mRNA. Translation: AFH28962.1.
JU472159 mRNA. Translation: AFH28963.1.
JU472160 mRNA. Translation: AFH28964.1.
JV044751 mRNA. Translation: AFI34822.1.
CM001268 Genomic DNA. Translation: EHH24484.1.
RefSeqNP_001040616.1. NM_001047151.2.
UniGeneMmu.3286.

3D structure databases

ProteinModelPortalE3U906.
SMRE3U906. Positions 94-297, 325-356.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID716170.
KEGGmcc:716170.

Organism-specific databases

CTD7157.

Phylogenomic databases

KOK04451.
OMAWNLLPEN.

Family and domain databases

Gene3D2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERPTHR11447. PTHR11447. 1 hit.
PfamPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSPR00386. P53SUPPRESSR.
SUPFAMSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEPS00348. P53. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19971313.

Entry information

Entry nameE3U906_MACMU
AccessionPrimary (citable) accession number: E3U906
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)