ID   BHLHW_PEA               Reviewed;         652 AA.
AC   E3SXU4;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Basic helix-loop-helix protein A;
GN   Name=BHLH;
OS   Pisum sativum (Garden pea) (Lathyrus oleraceus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=20949001; DOI=10.1371/journal.pone.0013230;
RA   Hellens R.P., Moreau C., Lin-Wang K., Schwinn K.E., Thomson S.J.,
RA   Fiers M.W., Frew T.J., Murray S.R., Hofer J.M., Jacobs J.M., Davies K.M.,
RA   Allan A.C., Bendahmane A., Coyne C.J., Timmerman-Vaughan G.M., Ellis T.H.;
RT   "Identification of Mendel's white flower character.";
RL   PLoS ONE 5:E13230-E13230(2010).
CC   -!- FUNCTION: Transcription activator involved in the control of flavonoid
CC       pigmentation. {ECO:0000269|PubMed:20949001}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- MISCELLANEOUS: Corresponds to one of the seven genes studied by Gregor
CC       Mendel in 1866. The white flowered cv. Cameor (a allele) has a
CC       truncated non-functional BHLH protein (AC E3SXU5) due to a point
CC       mutation resulting in a mis-spliced transcript (PubMed:20949001).
CC       {ECO:0000305|PubMed:20949001}.
CC   -!- SIMILARITY: Belongs to the bHLH protein family.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=On the garden pea - Issue
CC       159 of April 2014;
CC       URL="https://web.expasy.org/spotlight/back_issues/159/";
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DR   EMBL; GU132941; ADO13282.1; -; Genomic_DNA.
DR   AlphaFoldDB; E3SXU4; -.
DR   SMR; E3SXU4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR025610; MYC/MYB_N.
DR   PANTHER; PTHR46266; TRANSCRIPTION FACTOR TT8; 1.
DR   PANTHER; PTHR46266:SF4; TRANSCRIPTION FACTOR TT8; 1.
DR   Pfam; PF14215; bHLH-MYC_N; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   Activator; Flavonoid biosynthesis; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..652
FT                   /note="Basic helix-loop-helix protein A"
FT                   /id="PRO_0000425240"
FT   DOMAIN          464..513
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          233..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..260
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  72966 MW;  8BB3995E981EFB73 CRC64;
     MTAPTPENGC NKLQNMLQAA VQSVQWTYSL FWQICPQQLI LVWGDGYYNG AIKTRKTVQP
     MEVSAEEASL QRSQQLRELY ESLSAGETNP PTRRPCASLS PEDLTESEWF YLMCVSFSFP
     PGVGLPGKAY ARRQHVWLTG ANEVDSKTFS RAILAKSANI QTVVCIPVLD GVVEIGTTDK
     IQEDLNFIKH VRSFFIDHHS LPPKPALSEH STSNPTYSTD HIPAIMYTVA DPASTAIPNQ
     DDMDEDEEED DEDDEVESGS EDETNQGHNQ HATSIIEAAE PSELMQIEMP DDIRIGSPND
     GSNNLDSDFH LLAVSNQGNP SRQIDSYTTE RWGPIEEPLD DSLQIQLSSS VLHHPLEDLT
     QEDTHYSQTV TTILQNQWID SPSINYINYS TQSSFTTWTN HHFHPPPPPD PATSQWLVKY
     ILFTVPYLHT KNHDETSPQT RDTAGVNSND PSARLRGKGT PQDELSANHV LAERRRREKL
     NERFIILRSL VPFVTKMDKA SILGDTIEYL KQLRRKIQDL ETRNRQMESE KSGVTVLVGP
     TEKKKVRIVE GNGTGGGVRA KAVEVVASVQ VSIIESDALL EIECLQREGL LLDVMMMLRE
     LRIEVIGVQS SLNNGVFVAE LRAKVKENGN GKKVSIVEVK RALNQIIPHN NI
//