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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei751 – 7511Charge relay systemBy similarity
Active sitei828 – 8281Charge relay systemBy similarity
Active sitei861 – 8611Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:PTT_19734
OrganismiPyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres)
Taxonomic identifieri861557 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
ProteomesiUP000001067: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini115 – 907793VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Probable dipeptidyl-aminopeptidase BPRO_0000412161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi805 – 8051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E3S9K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRQRAPKEE EAELLTKQER STRSSEDASD ASVSSISTTS LVLEHINNPA
60 70 80 90 100
INGTSRSRRG EKYTDEDDEA QEAFDVEDGR YKAPVAVDKK TRRWLWIVGI
110 120 130 140 150
ACVTGWALAL VFFLMSGSYK HVSTRPHDPL ASSTKGSGKK ITMDDVFGGS
160 170 180 190 200
FYAQQQSVKW IAGPNGEDGL LLEKNTGNAG YLVVEDIRNK GDGDSSAKKT
210 220 230 240 250
KLMQKSSFDV DGKLVRPNEV WPSKDFKKVL VQSDFEKNWR HSGTGKYWIF
260 270 280 290 300
DVATQTGEPL DPENQDGRVQ LASLSPQSDA VVFTRDNNMY LRKLDSKEVI
310 320 330 340 350
QITRDGGSEL FYGIPDWVYE EEVFQGNSAT WWSEDGKYIA FLRTDESTVP
360 370 380 390 400
TYPVQYFVSR PSGNKPKAGE ENYPEVRNIK YPKAGAPNPI VALQFYDVEK
410 420 430 440 450
AEVFSVEIED DFRDNNRLIT EIVWAGKTKQ VLVRETNRES DILKVVLMDV
460 470 480 490 500
EKRTGKTVRT ENVAELDGGW FEVSQKTTFV PADPDNGRKD DGYIDTIIHE
510 520 530 540 550
GYDHIGYFTP LDNDKPVLLS QGEWEVVDAP SRVDLKNNMV YYVSTEKSSM
560 570 580 590 600
ERHAYSVFLN GTGTSEVVEN SGSGYYEASF SAGGSYALIT YQGPGIPWQK
610 620 630 640 650
IISTPSNKDK FEKVLEENKH LDRFVREREM PILNYQTIDV DGFKLNVLER
660 670 680 690 700
RPPHFNEKKK YPVLFYQYSG PNSQEVNKKF HVDFQAYVAA NLGYIVVTVD
710 720 730 740 750
GRGTGFLGRK LRCITRGNLG YYEAHDQIAA AKIWASKKYV DADRLAIWGW
760 770 780 790 800
SFGGFNTLKT LEQDGGQTFK YGMAVAPVTD WRYYDSIYTE RFMHMPQNNA
810 820 830 840 850
AGYDNSTITD VASLAKNTRF LIMHGVADDN VHMQNTLTLL DRLDLAGVEN
860 870 880 890 900
YDVHVFPDSD HSIYFHNANR IVYDKLRWWL INAFNGEWAK IKTAEPKSQV

DARLERR
Length:907
Mass (Da):102,862
Last modified:January 11, 2011 - v1
Checksum:i6A5E656B4F204015
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL537929 Genomic DNA. Translation: EFQ85356.1.
RefSeqiXP_003306558.1. XM_003306510.1.

Genome annotation databases

EnsemblFungiiEFQ85356; EFQ85356; PTT_19734.
GeneIDi10512411.
KEGGipte:PTT_19734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL537929 Genomic DNA. Translation: EFQ85356.1.
RefSeqiXP_003306558.1. XM_003306510.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFQ85356; EFQ85356; PTT_19734.
GeneIDi10512411.
KEGGipte:PTT_19734.

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres."
    Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S., Oliver R.P., Friesen T.L.
    Genome Biol. 11:R109.1-R109.14(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 0-1.

Entry informationi

Entry nameiDAPB_PYRTT
AccessioniPrimary (citable) accession number: E3S9K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 11, 2011
Last modified: January 7, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.