E3S7K9 (AMPP1_PYRTT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	ampp
ORF Names:	PTT_18815

Organism

Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres) [Complete proteome]

Taxonomic identifier

861557 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › Pyrenophora › Pyrenophora teres › Pyrenophora teres f. teres

Protein attributes

Sequence length	656 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 656	656	Probable Xaa-Pro aminopeptidase P		PRO_0000411808
Sites
	Metal binding	453	1	Manganese 2 By similarity
	Metal binding	464	1	Manganese 1 By similarity
	Metal binding	464	1	Manganese 2 By similarity
	Metal binding	562	1	Manganese 1 By similarity
	Metal binding	576	1	Manganese 1 By similarity
	Metal binding	576	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E3S7K9 [UniParc]. Last modified January 11, 2011. Version 1. Checksum: BAD2F9E88C9B38F6	FASTA	656	73,488
	10 20 30 40 50 60 MLLPRIPQLS HATRAAYVAA KSPFSPVPVR PFHASAALRA IDMAKVDTTH RLAELRKLMK 70 80 90 100 110 120 ERNVDIYMVP SEDSHQSEYI APCDARRAYI SGFTGSAGYA VITHEKAALS TDGRYFNQAE 130 140 150 160 170 180 KQLDSNWELL KQGIQDVPTI QQWTADQAGG GKVVGVDPSV VTAGDARKLA EKIKKKGGEY 190 200 210 220 230 240 KAIDENLVDL VWGSERPARP SEKVIVQPKK YAGKGFEDKI DDLRKELEKK KSLGFVVSML 250 260 270 280 290 300 DEVAWLFNLR GSDIPYNPVF FSYAVVTPTT ATLYVDENKL PEDVKEHLGD KITIRPYEAI 310 320 330 340 350 360 FGDVTALSKE LFEANDKNET QKKFLTSNTA SWALNKALGG DDKVEETRSP VGDSKAVKNE 370 380 390 400 410 420 VELEGMRQCH IRDGAALSEY FAWLEDQLIN KKATLDEVDG ADKLEEIRKK HDMFMGLSFD 430 440 450 460 470 480 TISSTGANAA VIHYKPEKGE CATIDSKAIY LCDSGAQYRD GTTDTTRTLH FTEPTEMERK 490 500 510 520 530 540 AYTLVLKGNM ALERVKFPKG TTGFALDALA RQFLWAEGLD YRHGTGHGVG SFLNVHEGPI 550 560 570 580 590 600 GIGTRVQYSE VSLAVGNVVS DEPGYYEDGK FGIRIENMVM VKEVETKHKF GDKPYLGFEH 610 620 630 640 650 VTMTPYCRNL VDMKLLTEDE KKFINDYHKE VYEKTSKYFD KDALTLEWLK RETAPY

References

[1]

"A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres." Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S., Oliver R.P., Friesen T.L. Genome Biol. 11:R109.1-R109.14(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 0-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL537558 Genomic DNA. Translation: EFQ86051.1.
RefSeq	XP_003305864.1. XM_003305816.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFQ86051; EFQ86051; PTT_18815.
GeneID	10517360.
KEGG	pte:PTT_18815.
Phylogenomic databases
KO	K01262.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_PYRTT

Accession

Primary (citable) accession number: E3S7K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program