E3RNJ5 (AMPP2_PYRTT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PTT_10145
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

PTT_10145

Organism

Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres) [Complete proteome]

Taxonomic identifier

861557 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › Pyrenophora › Pyrenophora teres › Pyrenophora teres f. teres

Protein attributes

Sequence length	926 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 926	926	Probable Xaa-Pro aminopeptidase PTT_10145		PRO_0000411850
Sites
	Metal binding	274	1	Manganese 2 By similarity
	Metal binding	285	1	Manganese 1 By similarity
	Metal binding	285	1	Manganese 2 By similarity
	Metal binding	435	1	Manganese 1 By similarity
	Metal binding	476	1	Manganese 1 By similarity
	Metal binding	476	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E3RNJ5 [UniParc]. Last modified January 11, 2011. Version 1. Checksum: F4B46BD92342492C	FASTA	926	104,628
	10 20 30 40 50 60 MEVLDATGLA ERLRWEDNDY WLHLEAETPF DKYPAKQHAR RVQAKLGIED GLIYLPGQPA 70 80 90 100 110 120 RNNEDSDMPA PFRQRRYFYY MSGCDEPDCH LMYDIRRDVL TLFIPRIKPE RVIWNGRGST 130 140 150 160 170 180 PAEALAKYDI DQVHHSQDLT YIIQNWAFKH QHTSIYILHP SSRIPGCDNL MPRIDSHSLQ 190 200 210 220 230 240 PAISLCRMIK DDHEIKRIRK ANDISSQAHR EVLANIHKYK NEAQVEGLFM DVCISQQAKQ 250 260 270 280 290 300 QAYDPIAASG PNAGTLHYDA NNEDLAGRQL MCLDAGCEYE LYASDITRTF PLSASWPSKE 310 320 330 340 350 360 AENIYNLVQR MQETCIERLE PGVRYLDLHI MAHQIAIDGL LRLGILCNGT REEIYKAGTS 370 380 390 400 410 420 RAFFPHGLGH HIGLEVHDVG QAELMSVRRG KPVYQQAPSL YPENFHDPVY DSETCHAPTD 430 440 450 460 470 480 PQSSHLEEGM VVTVEPGIYF SVYALQHFYL PSPIHSKFIN LEVLERYLPV GGVRIEDDLL 490 500 510 520 530 540 ITANGHENLT TAPKGEAMLD IIRQGNPGTT EILNPSPTPP RRMRSENRTP RLRAPGISKK 550 560 570 580 590 600 TLQPLLTPLA RAATLPTELR QQDDIDFEPI VGPSLFSGFS RAMTTEEKIQ QWKQKRDSVP 610 620 630 640 650 660 TAPSRPTKAK NLSPVCGENT ANVQHVYMST VSDLSSLSQS SVGSGSTSMC KNCGILVQTL 670 680 690 700 710 720 DRLRQNLSSS TQTSPKPMTV PTFESRQKSH TVEEKHREMV CTDSLLDKVS IGQSNRAIGP 730 740 750 760 770 780 EERRRKAQSD HHHHSRLKAA TGEVKSRFST RYTPAGVPPL MPSHDQYSIT RRPNPERMQP 790 800 810 820 830 840 VADTPIVPPR HLTYMTSTPQ QSTENPALAD LGLPRASAEI AAIRATKQAG QEKLDTQRTT 850 860 870 880 890 900 LDAFQDEGQR LVIRSRHRLI PQTSMPVLMS QNPYHHHSNR SHGREGNNAT NKRSMIDSQP 910 920 AERRTRPERP ERPARDYVPG DEFLTR

References

[1]

"A first genome assembly of the barley fungal pathogen Pyrenophora teres f. teres." Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S., Oliver R.P., Friesen T.L. Genome Biol. 11:R109.1-R109.14(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 0-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL534210 Genomic DNA. Translation: EFQ92700.1.
RefSeq	XP_003299200.1. XM_003299152.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFQ92700; EFQ92700; PTT_10145.
GeneID	10519120.
KEGG	pte:PTT_10145.
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_PYRTT

Accession

Primary (citable) accession number: E3RNJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program