E3QYP0 (AMPP3_COLGM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	GLRG_11122

Organism

Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) [Complete proteome]

Taxonomic identifier

645133 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Glomerellales › Glomerellaceae › Glomerella › Colletotrichum graminicola

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411871
Sites
	Metal binding	257	1	Manganese 2 By similarity
	Metal binding	268	1	Manganese 1 By similarity
	Metal binding	268	1	Manganese 2 By similarity
	Metal binding	391	1	Manganese 1 By similarity
	Metal binding	431	1	Manganese 1 By similarity
	Metal binding	431	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E3QYP0 [UniParc]. Last modified January 11, 2011. Version 1. Checksum: 2DEBD8E93DD6D198	FASTA	461	51,662
	10 20 30 40 50 60 MTQDYETVLK GKYPAKEHAL RVADYVKSKV PDATGILYVE GRMTKMLEDN DEPEPFRQRR 70 80 90 100 110 120 YFYYLTGCPL ADCHYIFDLA TSKSTLFIPP IDPDSVIWSG LPVSAAEAKE LYDVDEVKYT 130 140 150 160 170 180 TDVNAELARL GKGPKKTVFA IQNQVLDSIT FLEFDEKNFS ILKDAIERCR VVKDDYEIAL 190 200 210 220 230 240 TRKANAVSTV AHHAVVEYVK KAKNERELEA LFLQRSVANG AKNQAYHGIF AGGRAAATLH 250 260 270 280 290 300 YVANDAPLEG KLNLLLDAGT EWNCYASDIT RTFPISGKFS KESRQIYDIV LKMQLETTAA 310 320 330 340 350 360 LKEGVIWDEI HLLAHKIAID GLHLIGILKG DKDEILKNRT SVAFFPHGLG HYLGMDTHDV 370 380 390 400 410 420 GGNANYADRD PMFRYLRVRG ALPAGSIVTV EPGIYFCSFI IEPYLKDPVH SKFIDSAVLE 430 440 450 460 KYWDVGGVRI EDNILITKDG SENLTPTIKD PDELEKIIQA S

References

[1]

"Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses." O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J., Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J., Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z., Choi J., Crouch J.A. , Duvick J.P., Farman M.A., Gan P., Heiman D., Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y., Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U., Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H., Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L., Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K., Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F., van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J., Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E., Ma L.-J., Vaillancourt L.J. Nat. Genet. 44:1060-1065(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M1.001 / M2 / FGSC 10212.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG697405 Genomic DNA. Translation: EFQ35978.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFQ35978; EFQ35978; GLRG_11122.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AMPP3_COLGM

Accession

Primary (citable) accession number: E3QYP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program