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E3QR43 (CBPYA_COLGM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 130113 By similarity
PRO_0000407447
Chain131 – 545415Carboxypeptidase Y homolog A
PRO_0000407448

Sites

Active site2711 By similarity
Active site4631 By similarity
Active site5211 By similarity

Amino acid modifications

Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation5101N-linked (GlcNAc...) Potential
Disulfide bond184 ↔ 424 By similarity
Disulfide bond318 ↔ 332 By similarity
Disulfide bond342 ↔ 365 By similarity
Disulfide bond349 ↔ 358 By similarity
Disulfide bond387 ↔ 394 By similarity

Sequences

Sequence LengthMass (Da)Tools
E3QR43 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: BE47D30082A91640

FASTA54560,571
        10         20         30         40         50         60 
MRFSTSALVL GAASTAVALD QQVLGGNESP FDSIKVAGQE WLSTFEEKFG KMTTEAKAVW 

        70         80         90        100        110        120 
DEITLLAPDA VESFKKNAIP PKPKPAHRKS DKKWDHVVKG ADVQSMWVEK NGEKHRKIAG 

       130        140        150        160        170        180 
DLKNFNLRAK KVDPSALGID KVKQYSGYLD DEENDKHLFY WFFESRNDPK NDPVVLWLNG 

       190        200        210        220        230        240 
GPGCSSLTGL FMELGPASVD KKLKIVNNEW SWNNNASVIF LDQPVNVGYS YSGSSVSNTV 

       250        260        270        280        290        300 
AAGKDVYALL SLFFHQFPEY SKQDFHIAGE SYAGHYIPVF ASEILSHEDR NINLKSVLIG 

       310        320        330        340        350        360 
NGLTDGLTQY GYYRPMACGE GGYPAVLDAG ECQAMDNALP RCQSLINNCY ESGSVWSCVP 

       370        380        390        400        410        420 
ASIYCNNALI GPYQRTGQNV YDIRGKCEDS SNLCYSALGW ISEYLNQDEV KEALGAEVDS 

       430        440        450        460        470        480 
YDSCNFDINR NFLFAGDWFQ PFHRIVPKLL EKIPVLIYAG DADYICNWLG NRAWTEALEW 

       490        500        510        520        530        540 
PGQKGFNKAE VKSLAVGKGK EYGKVKSSGN FTFMQLYGAG HMVPMDQPEA SSDFLNRWLG 


GEWVA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG697369 Genomic DNA. Translation: EFQ33331.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFQ33331; EFQ33331; GLRG_08475.

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_COLGM
AccessionPrimary (citable) accession number: E3QR43
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 11, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries