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E3QR43

- CBPYA_COLGM

UniProt

E3QR43 - CBPYA_COLGM

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei271 – 2711PROSITE-ProRule annotation
    Active sitei463 – 4631PROSITE-ProRule annotation
    Active sitei521 – 5211PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:GLRG_08475
    OrganismiColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
    Taxonomic identifieri645133 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaemitosporic GlomerellaceaeColletotrichum
    ProteomesiUP000008782: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 130113By similarityPRO_0000407447Add
    BLAST
    Chaini131 – 545415Carboxypeptidase Y homolog APRO_0000407448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi184 ↔ 424By similarity
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi318 ↔ 332By similarity
    Disulfide bondi342 ↔ 365By similarity
    Disulfide bondi349 ↔ 358By similarity
    Disulfide bondi387 ↔ 394By similarity
    Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E3QR43-1 [UniParc]FASTAAdd to Basket

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    MRFSTSALVL GAASTAVALD QQVLGGNESP FDSIKVAGQE WLSTFEEKFG    50
    KMTTEAKAVW DEITLLAPDA VESFKKNAIP PKPKPAHRKS DKKWDHVVKG 100
    ADVQSMWVEK NGEKHRKIAG DLKNFNLRAK KVDPSALGID KVKQYSGYLD 150
    DEENDKHLFY WFFESRNDPK NDPVVLWLNG GPGCSSLTGL FMELGPASVD 200
    KKLKIVNNEW SWNNNASVIF LDQPVNVGYS YSGSSVSNTV AAGKDVYALL 250
    SLFFHQFPEY SKQDFHIAGE SYAGHYIPVF ASEILSHEDR NINLKSVLIG 300
    NGLTDGLTQY GYYRPMACGE GGYPAVLDAG ECQAMDNALP RCQSLINNCY 350
    ESGSVWSCVP ASIYCNNALI GPYQRTGQNV YDIRGKCEDS SNLCYSALGW 400
    ISEYLNQDEV KEALGAEVDS YDSCNFDINR NFLFAGDWFQ PFHRIVPKLL 450
    EKIPVLIYAG DADYICNWLG NRAWTEALEW PGQKGFNKAE VKSLAVGKGK 500
    EYGKVKSSGN FTFMQLYGAG HMVPMDQPEA SSDFLNRWLG GEWVA 545
    Length:545
    Mass (Da):60,571
    Last modified:January 11, 2011 - v1
    Checksum:iBE47D30082A91640
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG697369 Genomic DNA. Translation: EFQ33331.1.

    Genome annotation databases

    EnsemblFungiiEFQ33331; EFQ33331; GLRG_08475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG697369 Genomic DNA. Translation: EFQ33331.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFQ33331 ; EFQ33331 ; GLRG_08475 .

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses."
      O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J., Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J., Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z., Choi J., Crouch J.A.
      , Duvick J.P., Farman M.A., Gan P., Heiman D., Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y., Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U., Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H., Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L., Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K., Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F., van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J., Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E., Ma L.-J., Vaillancourt L.J.
      Nat. Genet. 44:1060-1065(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M1.001 / M2 / FGSC 10212.

    Entry informationi

    Entry nameiCBPYA_COLGM
    AccessioniPrimary (citable) accession number: E3QR43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3