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Protein

Leucine aminopeptidase 1

Gene

LAP1

Organism
Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.By similarity

Catalytic activityi

Release of an N-terminal amino acid from a peptide.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Zinc 1By similarity1
Metal bindingi206Zinc 1By similarity1
Metal bindingi206Zinc 2; catalyticBy similarity1
Metal bindingi245Zinc 2; catalyticBy similarity1
Metal bindingi272Zinc 1By similarity1
Metal bindingi354Zinc 2; catalyticBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine aminopeptidase 1 (EC:3.4.11.-)
Alternative name(s):
Leucyl aminopeptidase 1
Short name:
LAP1
Gene namesi
Name:LAP1
ORF Names:GLRG_08381
OrganismiColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Taxonomic identifieri645133 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaeColletotrichum
Proteomesi
  • UP000008782 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000041240519 – 87By similarityAdd BLAST69
ChainiPRO_000041240688 – 401Leucine aminopeptidase 1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi321 ↔ 325By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliE3QQU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M28 family. M28E subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG092C2C8H.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E3QQU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAKASLLT ILAHSVSARF LAEDEINRVQ LYPAGSEPEK YLIELAPGDT
60 70 80 90 100
RWVTEEEKWE LRRNGNRFFD ITDHKDLGAT RLRTKTKSVF PEKCSLQDKV
110 120 130 140 150
KPLLKDLDKS EIQKNLEKFT SFHTRYYKSD YGRQSSEWLL AKIDSIIKDA
160 170 180 190 200
GADKNVYAQP FPHTWQQSSI IVTIPGKSNS TVIIGAHQDS INLWLPSILA
210 220 230 240 250
APGADDDGSG SMTILEAFRT LLKSKDIVSG KADNTIEFHW YSAEEGGLLG
260 270 280 290 300
SQAIFSSYEK EGRDIKAMLQ QDMTGFVQRT LDAGQPESVG VITDFVDPGL
310 320 330 340 350
TGFIKKVIVE YCKVPYVETK CGYACSDHAS ASKAGYPSAF VIESAFEYSD
360 370 380 390 400
NHIHSVDDTI KYLSFDHMLE HAKMTLGLVY ELGFTDFTAL EKKGESVSEE

L
Length:401
Mass (Da):44,812
Last modified:January 11, 2011 - v1
Checksum:i2868A43AE5F44660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG697368 Genomic DNA. Translation: EFQ33237.1.
RefSeqiXP_008097257.1. XM_008099066.1.

Genome annotation databases

EnsemblFungiiEFQ33237; EFQ33237; GLRG_08381.
GeneIDi24413746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG697368 Genomic DNA. Translation: EFQ33237.1.
RefSeqiXP_008097257.1. XM_008099066.1.

3D structure databases

ProteinModelPortaliE3QQU9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFQ33237; EFQ33237; GLRG_08381.
GeneIDi24413746.

Phylogenomic databases

OrthoDBiEOG092C2C8H.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAP1_COLGM
AccessioniPrimary (citable) accession number: E3QQU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.