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E3QQU9

- LAP1_COLGM

UniProt

E3QQU9 - LAP1_COLGM

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Protein
Leucine aminopeptidase 1
Gene
LAP1, GLRG_08381
Organism
Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular aminopeptidase that allows assimilation of proteinaceous substrates By similarity.

Catalytic activityi

Release of an N-terminal amino acid from a peptide.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc 1 By similarity
Metal bindingi206 – 2061Zinc 1 By similarity
Metal bindingi206 – 2061Zinc 2; catalytic By similarity
Metal bindingi245 – 2451Zinc 2; catalytic By similarity
Metal bindingi272 – 2721Zinc 1 By similarity
Metal bindingi354 – 3541Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM28.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine aminopeptidase 1 (EC:3.4.11.-)
    Alternative name(s):
    Leucyl aminopeptidase 1
    Short name:
    LAP1
    Gene namesi
    Name:LAP1
    ORF Names:GLRG_08381
    OrganismiColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
    Taxonomic identifieri645133 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaemitosporic GlomerellaceaeColletotrichum
    ProteomesiUP000008782: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818 Reviewed prediction
    Add
    BLAST
    Propeptidei19 – 8769 By similarity
    PRO_0000412405Add
    BLAST
    Chaini88 – 401314Leucine aminopeptidase 1
    PRO_0000412406Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi321 ↔ 325 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Subunit structurei

    Monomer By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliE3QQU9.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7GQZ51.

    Family and domain databases

    InterProiIPR007484. Peptidase_M28.
    [Graphical view]
    PfamiPF04389. Peptidase_M28. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E3QQU9-1 [UniParc]FASTAAdd to Basket

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    MKVAKASLLT ILAHSVSARF LAEDEINRVQ LYPAGSEPEK YLIELAPGDT    50
    RWVTEEEKWE LRRNGNRFFD ITDHKDLGAT RLRTKTKSVF PEKCSLQDKV 100
    KPLLKDLDKS EIQKNLEKFT SFHTRYYKSD YGRQSSEWLL AKIDSIIKDA 150
    GADKNVYAQP FPHTWQQSSI IVTIPGKSNS TVIIGAHQDS INLWLPSILA 200
    APGADDDGSG SMTILEAFRT LLKSKDIVSG KADNTIEFHW YSAEEGGLLG 250
    SQAIFSSYEK EGRDIKAMLQ QDMTGFVQRT LDAGQPESVG VITDFVDPGL 300
    TGFIKKVIVE YCKVPYVETK CGYACSDHAS ASKAGYPSAF VIESAFEYSD 350
    NHIHSVDDTI KYLSFDHMLE HAKMTLGLVY ELGFTDFTAL EKKGESVSEE 400
    L 401
    Length:401
    Mass (Da):44,812
    Last modified:January 11, 2011 - v1
    Checksum:i2868A43AE5F44660
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG697368 Genomic DNA. Translation: EFQ33237.1.

    Genome annotation databases

    EnsemblFungiiEFQ33237; EFQ33237; GLRG_08381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG697368 Genomic DNA. Translation: EFQ33237.1 .

    3D structure databases

    ProteinModelPortali E3QQU9.
    ModBasei Search...

    Protein family/group databases

    MEROPSi M28.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFQ33237 ; EFQ33237 ; GLRG_08381 .

    Phylogenomic databases

    OrthoDBi EOG7GQZ51.

    Family and domain databases

    InterProi IPR007484. Peptidase_M28.
    [Graphical view ]
    Pfami PF04389. Peptidase_M28. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses."
      O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J., Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J., Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z., Choi J., Crouch J.A.
      , Duvick J.P., Farman M.A., Gan P., Heiman D., Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y., Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U., Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H., Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L., Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K., Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F., van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J., Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E., Ma L.-J., Vaillancourt L.J.
      Nat. Genet. 44:1060-1065(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M1.001 / M2 / FGSC 10212.

    Entry informationi

    Entry nameiLAP1_COLGM
    AccessioniPrimary (citable) accession number: E3QQU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: January 11, 2011
    Last modified: July 9, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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