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E3QQU9

- LAP1_COLGM

UniProt

E3QQU9 - LAP1_COLGM

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Protein

Leucine aminopeptidase 1

Gene

LAP1

Organism
Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.By similarity

Catalytic activityi

Release of an N-terminal amino acid from a peptide.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc 1By similarity
Metal bindingi206 – 2061Zinc 1By similarity
Metal bindingi206 – 2061Zinc 2; catalyticBy similarity
Metal bindingi245 – 2451Zinc 2; catalyticBy similarity
Metal bindingi272 – 2721Zinc 1By similarity
Metal bindingi354 – 3541Zinc 2; catalyticBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM28.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine aminopeptidase 1 (EC:3.4.11.-)
Alternative name(s):
Leucyl aminopeptidase 1
Short name:
LAP1
Gene namesi
Name:LAP1
ORF Names:GLRG_08381
OrganismiColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Taxonomic identifieri645133 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaemitosporic GlomerellaceaeColletotrichum
ProteomesiUP000008782: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 8769By similarityPRO_0000412405Add
BLAST
Chaini88 – 401314Leucine aminopeptidase 1PRO_0000412406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi321 ↔ 325By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliE3QQU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M28 family. M28E subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7GQZ51.

Family and domain databases

InterProiIPR007484. Peptidase_M28.
[Graphical view]
PfamiPF04389. Peptidase_M28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E3QQU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVAKASLLT ILAHSVSARF LAEDEINRVQ LYPAGSEPEK YLIELAPGDT
60 70 80 90 100
RWVTEEEKWE LRRNGNRFFD ITDHKDLGAT RLRTKTKSVF PEKCSLQDKV
110 120 130 140 150
KPLLKDLDKS EIQKNLEKFT SFHTRYYKSD YGRQSSEWLL AKIDSIIKDA
160 170 180 190 200
GADKNVYAQP FPHTWQQSSI IVTIPGKSNS TVIIGAHQDS INLWLPSILA
210 220 230 240 250
APGADDDGSG SMTILEAFRT LLKSKDIVSG KADNTIEFHW YSAEEGGLLG
260 270 280 290 300
SQAIFSSYEK EGRDIKAMLQ QDMTGFVQRT LDAGQPESVG VITDFVDPGL
310 320 330 340 350
TGFIKKVIVE YCKVPYVETK CGYACSDHAS ASKAGYPSAF VIESAFEYSD
360 370 380 390 400
NHIHSVDDTI KYLSFDHMLE HAKMTLGLVY ELGFTDFTAL EKKGESVSEE

L
Length:401
Mass (Da):44,812
Last modified:January 11, 2011 - v1
Checksum:i2868A43AE5F44660
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG697368 Genomic DNA. Translation: EFQ33237.1.

Genome annotation databases

EnsemblFungiiEFQ33237; EFQ33237; GLRG_08381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG697368 Genomic DNA. Translation: EFQ33237.1 .

3D structure databases

ProteinModelPortali E3QQU9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M28.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFQ33237 ; EFQ33237 ; GLRG_08381 .

Phylogenomic databases

OrthoDBi EOG7GQZ51.

Family and domain databases

InterProi IPR007484. Peptidase_M28.
[Graphical view ]
Pfami PF04389. Peptidase_M28. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses."
    O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J., Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J., Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z., Choi J., Crouch J.A.
    , Duvick J.P., Farman M.A., Gan P., Heiman D., Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y., Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U., Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H., Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L., Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K., Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F., van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J., Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E., Ma L.-J., Vaillancourt L.J.
    Nat. Genet. 44:1060-1065(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M1.001 / M2 / FGSC 10212.

Entry informationi

Entry nameiLAP1_COLGM
AccessioniPrimary (citable) accession number: E3QQU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3