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E3QDT3 (KEX1_COLGM) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:GLRG_04165
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) [Complete proteome]
Taxonomic identifier645133 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaemitosporic GlomerellaceaeColletotrichum

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 622599Pheromone-processing carboxypeptidase KEX1
PRO_0000411916

Regions

Topological domain24 – 509486Lumenal Potential
Transmembrane510 – 53021Helical; Potential
Topological domain531 – 62292Cytoplasmic Potential

Sites

Active site1751 By similarity
Active site3751 By similarity
Active site4371 By similarity

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
E3QDT3 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: DBAEAB5DEFF84EC0

FASTA62270,070
        10         20         30         40         50         60 
MAILSTVPAL LFALASWAPT VAAQSAADYF VHELPGAPKE PFIKMHAGHV EVTPEHNGNI 

        70         80         90        100        110        120 
FFWHFQNQHI ANKQRTVIWL NGGPGCSSED GALMEIGPYR VKDPDHLEYN NGSWNEFANL 

       130        140        150        160        170        180 
LFVDNPVGTG FSFVDTNSYL HELPEMADQF VQFLEKWFAM FPEYEHDDLY ISGESYAGQH 

       190        200        210        220        230        240 
IPYIAKHILE RNKKPGVKTP WQLKGLLMGN AWISPKEQYD AYLKYAYEKK LIEKGSPIAL 

       250        260        270        280        290        300 
QLEQQWRICR TSLAVTNTVD FTECESVLQK LLEQTAKVNA KGERECINMY DIRLRDTFPS 

       310        320        330        340        350        360 
CGMNWPPDLV NLTPYLRKAE VVSALHIKPQ KTTGWTECNG AVGSAFRAPN SVPSRDYLPD 

       370        380        390        400        410        420 
LLKEVPIVLF SGAEDLICNY MGTEAMIGDM EWNGGKGFEL TPGNWAPRRD WTVEGQPAGF 

       430        440        450        460        470        480 
WQEARNLTYI LFYNSSHMVP FDYARRSRDM LDRFMNVDIS SVGGTPTDSR LDGEQGPATS 

       490        500        510        520        530        540 
VGDIGKNGTS ADAETQKKLD EAKWKAYYRS GEIVLVIVII AAGAWGWYVW RERRKRRGYS 

       550        560        570        580        590        600 
GIMGNTPPIA QRGTTRGLEG FRDRRTGRDV ETGDFDESEL DDLHVTTPTV EMDKDRYSVG 

       610        620 
GDSDDEPHDE KPSRSNGGRS GR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG697343 Genomic DNA. Translation: EFQ29021.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFQ29021; EFQ29021; GLRG_04165.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_COLGM
AccessionPrimary (citable) accession number: E3QDT3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 11, 2011
Last modified: March 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries