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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

GLRG_02475

Organism
Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (GLRG_02475)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Transferase
Biological processCarotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773
UPA00802

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:GLRG_02475
OrganismiColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola)
Taxonomic identifieri645133 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaeColletotrichum
Proteomesi
  • UP000008782 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004092351 – 587Bifunctional lycopene cyclase/phytoene synthaseAdd BLAST587

Proteomic databases

PRIDEiE3Q717

Structurei

3D structure databases

ProteinModelPortaliE3Q717
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 242Lycopene beta-cyclaseAdd BLAST242
Regioni249 – 587Phytoene synthaseAdd BLAST339

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG092C1GQ8

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR017825 Lycopene_cyclase_dom
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR03462 CarR_dom_SF, 2 hits
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

E3Q717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYDYALVHV KYTIPLAALL TVFSYPVFTR LDVVRTLFIV TIAFVATIPW
60 70 80 90 100
DSYLIRTNVW TYPPDAVLGP TLYDIPAEEL FFFIIQTYIT AQLYIILNKP
110 120 130 140 150
VLHAQYLNSP ATLPQWIKSG KLVGQLALSG SVLLGTWLIA KKGEGTYLGL
160 170 180 190 200
ILVWACTFAL FTWTITAHFL LALPLACTAL PILLPTVYLW IVDEMALGRG
210 220 230 240 250
TWAIESGTKL ELQLFGSLEI EEATFFLVTN MLIVFGIAAF DKAVAVCDAF
260 270 280 290 300
PEKFDKPADA LAMSLLRARV FPSSKYDMQR ILGIRQAAAR LAKKSRSFHL
310 320 330 340 350
ASSVFPGRLR IDLTLLYSYC RLADDLVDDA ATPEEAAVWI SKLDRHLSLL
360 370 380 390 400
YKDPDATSTP LASKYAAENF PPSALSALDM LPTSLLPREP LAELLKGFEM
410 420 430 440 450
DLSFSNSAFP IADPEDLELY AARVASTVGQ ACLELVFCHC QHGLPDYMKA
460 470 480 490 500
YLRNTARQMG LALQFVNISR DIAVDAKIGR VYLPTTWLKE EGLTPEDVLK
510 520 530 540 550
SPNSEGVGKV RRRILAKALD HYGEARDSMK WIPSEARGPM IVAVESYMEI
560 570 580
GRVLMRNGGS AAADGSGRAT VPKSRRIWVA WSTLMAA
Length:587
Mass (Da):64,983
Last modified:January 11, 2011 - v1
Checksum:i6D39085251FBB666
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG697335 Genomic DNA Translation: EFQ26655.1
RefSeqiXP_008090675.1, XM_008092484.1

Genome annotation databases

EnsemblFungiiEFQ26655; EFQ26655; GLRG_02475
GeneIDi24407840

Similar proteinsi

Entry informationi

Entry nameiLCPS_COLGM
AccessioniPrimary (citable) accession number: E3Q717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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