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E3Q717 (LCPS_COLGM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:GLRG_02475
OrganismColletotrichum graminicola (strain M1.001 / M2 / FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) [Complete proteome]
Taxonomic identifier645133 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Glomerellales › Glomerellaceae › Glomerella ›

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Keywords
   Biological processCarotenoid biosynthesis
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionIsomerase
Transferase
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Biological_processcarotenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiongeranylgeranyl-diphosphate geranylgeranyltransferase activity

Inferred from electronic annotation. Source: EC

intramolecular lyase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409235

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane220 – 24021Helical; Potential
Region1 – 242242Lycopene beta-cyclase
Region249 – 587339Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
E3Q717 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 6D39085251FBB666

FASTA58764,983
        10         20         30         40         50         60 
MGYDYALVHV KYTIPLAALL TVFSYPVFTR LDVVRTLFIV TIAFVATIPW DSYLIRTNVW 

        70         80         90        100        110        120 
TYPPDAVLGP TLYDIPAEEL FFFIIQTYIT AQLYIILNKP VLHAQYLNSP ATLPQWIKSG 

       130        140        150        160        170        180 
KLVGQLALSG SVLLGTWLIA KKGEGTYLGL ILVWACTFAL FTWTITAHFL LALPLACTAL 

       190        200        210        220        230        240 
PILLPTVYLW IVDEMALGRG TWAIESGTKL ELQLFGSLEI EEATFFLVTN MLIVFGIAAF 

       250        260        270        280        290        300 
DKAVAVCDAF PEKFDKPADA LAMSLLRARV FPSSKYDMQR ILGIRQAAAR LAKKSRSFHL 

       310        320        330        340        350        360 
ASSVFPGRLR IDLTLLYSYC RLADDLVDDA ATPEEAAVWI SKLDRHLSLL YKDPDATSTP 

       370        380        390        400        410        420 
LASKYAAENF PPSALSALDM LPTSLLPREP LAELLKGFEM DLSFSNSAFP IADPEDLELY 

       430        440        450        460        470        480 
AARVASTVGQ ACLELVFCHC QHGLPDYMKA YLRNTARQMG LALQFVNISR DIAVDAKIGR 

       490        500        510        520        530        540 
VYLPTTWLKE EGLTPEDVLK SPNSEGVGKV RRRILAKALD HYGEARDSMK WIPSEARGPM 

       550        560        570        580 
IVAVESYMEI GRVLMRNGGS AAADGSGRAT VPKSRRIWVA WSTLMAA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GG697335 Genomic DNA. Translation: EFQ26655.1.

3D structure databases

ProteinModelPortalE3Q717.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFQ26655; EFQ26655; GLRG_02475.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_COLGM
AccessionPrimary (citable) accession number: E3Q717
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: January 11, 2011
Last modified: April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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