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E3PX93 (E3PX93_CLOSD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CBH21058.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:CLOST_0933 EMBL CBH21058.1
OrganismClostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654) [Complete proteome] [HAMAP]
Taxonomic identifier499177 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceae

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding167 – 22256ATP By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E3PX93 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: B8CF2755C294C16C

FASTA30634,180
        10         20         30         40         50         60 
MNIGLIFGGK SAEYEVSLQS AMHIYKRLNK DVHNVYLIGM DRDGFMHYFD GSIEEVSDGS 

        70         80         90        100        110        120 
WFDKKTSAEV ILYSNKKKPG IYDNDKVIAE LELVFPVLHG PYGEDGKLQG LLELSGIPYV 

       130        140        150        160        170        180 
GCSVLASANG MDKDMAKKIF SYEGINQVPH ITCYSYEQTQ EIVSRAEANL GYPCFIKPAN 

       190        200        210        220        230        240 
MGSSVGISKA KDKQQLVLAM QKAFEYDHKI IIEKGVNARE IEVAVLGNCD NIRISVAGEI 

       250        260        270        280        290        300 
IPSDEFYDYD AKYKSNASQL IIPADLSFEA DRQIQDMAYR AYKGLNAEGL CRIRFFCRQG 


YSKGVS 

« Hide

References

[1]"Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence."
Fonknechten N., Chaussonnerie S., Tricot S., Lajus A., Andreesen J.R., Perchat N., Pelletier E., Gouyvenoux M., Barbe V., Salanoubat M., Le Paslier D., Weissenbach J., Cohen G.N., Kreimeyer A.
BMC Genomics 11:555-555(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FP565809 Genomic DNA. Translation: CBH21058.1.
RefSeqYP_003935963.1. NC_014614.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBH21058; CBH21058; CLOST_0933.
GeneID9854585.
KEGGcst:CLOST_0933.
PATRIC42272509. VBICloSti32817_0930.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.

Enzyme and pathway databases

BioCycCSTI499177:GJE9-976-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE3PX93_CLOSD
AccessionPrimary (citable) accession number: E3PX93
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)