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E3PTM8 (E3PTM8_CLOSD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 RuleBase RU004247 SAAS SAAS009006

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201 RuleBase RU004247

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site391Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2681Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1371Substrate By similarity HAMAP-Rule MF_01201
Binding site3161Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue391N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
E3PTM8 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 79CEDBB61FDEE6A2

FASTA38443,610
        10         20         30         40         50         60 
MSHTFRPTWA EINLDHVKAN YNNIRKLLKP ETKFCAVIKA NAYGHGAVQY AKVLDKEGAD 

        70         80         90        100        110        120 
YFAVAVCEEA LELRQNSITK PIMCLGYVPE DRFKDMMQNN VDITIYSYEK AALLSQIAKD 

       130        140        150        160        170        180 
NNLNAKIHIK LDSGMSRLGL QCDNEAVDEI LKISTLENLE IVGIFTHFAL ADDKDLSYTH 

       190        200        210        220        230        240 
EQYKNYSFVV NELETKGLKI PIKHVCNSAA TMMLPEYHLD MVRPGIILYG HYPSDDVDKS 

       250        260        270        280        290        300 
KVKLYPAMAL KSTVAHVKKL EEGRGISYGH KYRSKENEII ATIPIGYADG FTRMLSGQAD 

       310        320        330        340        350        360 
VKLNDKMVPV VGRICMDQCM LSLEEEAKVG DQITIFSDEE GMDIERFAQR LGTINYELLC 

       370        380 
MVQRRVPRIY KEDGKIIKVQ DYLI 

« Hide

References

[1]"Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence."
Fonknechten N., Chaussonnerie S., Tricot S., Lajus A., Andreesen J.R., Perchat N., Pelletier E., Gouyvenoux M., Barbe V., Salanoubat M., Le Paslier D., Weissenbach J., Cohen G.N., Kreimeyer A.
BMC Genomics 11:555-555(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FP565809 Genomic DNA. Translation: CBH22232.1.
RefSeqYP_003937137.1. NC_014614.1.

3D structure databases

ProteinModelPortalE3PTM8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBH22232; CBH22232; CLOST_2112.
GeneID9855333.
KEGGcst:CLOST_2112.
PATRIC42274857. VBICloSti32817_2100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.

Enzyme and pathway databases

BioCycCSTI499177:GJE9-2177-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE3PTM8_CLOSD
AccessionPrimary (citable) accession number: E3PTM8
Entry history
Integrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)