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Protein

8-amino-7-ketopelargonate synthase

Gene

kbl

Organism
Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654) (Clostridium sticklandii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.UniRule annotationSAAS annotation

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseImported, Transferase
Biological processBiotin biosynthesisSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-ketopelargonate synthaseUniRule annotation (EC:2.3.1.47UniRule annotation)
Gene namesi
Name:kblImported
Ordered Locus Names:CLOST_1620Imported
OrganismiAcetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654) (Clostridium sticklandii)Imported
Taxonomic identifieri499177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeAcetoanaerobium
Proteomesi
  • UP000007041 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi499177.CLOST_1620

Structurei

3D structure databases

ProteinModelPortaliE3PS86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 385Aminotran_1_2InterPro annotationAdd BLAST342

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EEK Bacteria
COG0156 LUCA
HOGENOMiHOG000221022
KOiK00639
OMAiFGTIGEN
OrthoDBiPOG091H024U

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR010962 AONS_Archaea/Firmicutes
IPR004723 AONS_Archaea/Proteobacteria
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00858 bioF, 1 hit
TIGR01825 gly_Cac_T_rel, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

E3PS86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIHEMGFI KEKIDELKQA GLYKEVVTLD GPNEAECSIN GKMAINLSSN
60 70 80 90 100
NYLGFSNHPR LKKAAIEAIE KYGAGAGAVR PIIGNMKIHD ELEALLAVFK
110 120 130 140 150
KEEAVLVFQS GFNCNAGTIQ AVTEAGDLIL SDELNHASII DGARLSKAKK
160 170 180 190 200
ATYKHSDMAD LERVLKETRS EYNNVLIITD GVFSMDGDIA KLPEIVELAE
210 220 230 240 250
KYNCMTYVDD AHSSGVLGHS GRGTVDHFDL HGRVDFTIGT LSKAIGVVGG
260 270 280 290 300
YVAGKKVTID WLKNRGRPFL FSTGMTPSAV GSIIEAIKML MESEEYTDKL
310 320 330 340 350
WDNARYFKEK MSVLGFNTGE SETPITPIII GEEAKAIEFS KKLFEAGVFV
360 370 380 390
SPIVFPTVPK GTGRVRCMVT AGHTKEQLDR AVDAFTKVGK EMNII
Length:395
Mass (Da):43,149
Last modified:January 11, 2011 - v1
Checksum:i25F2F89D54BEF324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565809 Genomic DNA Translation: CBH21740.1
RefSeqiWP_013361833.1, NC_014614.1

Genome annotation databases

EnsemblBacteriaiCBH21740; CBH21740; CLOST_1620
GeneIDi35558698
KEGGicst:CLOST_1620

Similar proteinsi

Entry informationi

Entry nameiE3PS86_ACESD
AccessioniPrimary (citable) accession number: E3PS86
Entry historyiIntegrated into UniProtKB/TrEMBL: January 11, 2011
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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