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Protein

3-aminobutyryl-CoA ammonia lyase

Gene

kal

Organism
Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654) (Clostridium sticklandii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the anaerobic fermentation of lysine. Catalyzes the deamination of L-3-aminobutyryl-CoA to produce crotonoyl-CoA.By similarity

Catalytic activityi

L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3.By similarity

Pathwayi: L-lysine degradation via acetate pathway

This protein is involved in the pathway L-lysine degradation via acetate pathway, which is part of Amino-acid degradation.By similarity
View all proteins of this organism that are known to be involved in the pathway L-lysine degradation via acetate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciCSTI499177:GJE9-1434-MONOMER.
UniPathwayiUPA00870.

Names & Taxonomyi

Protein namesi
Recommended name:
3-aminobutyryl-CoA ammonia lyaseBy similarity (EC:4.3.1.14By similarity)
Alternative name(s):
3-aminobutyryl-CoA deaminaseBy similarity
Gene namesi
Name:kalBy similarity
Ordered Locus Names:CLOST_1385
OrganismiAcetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654) (Clostridium sticklandii)
Taxonomic identifieri499177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeAcetoanaerobium
Proteomesi
  • UP000007041 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169781 – 1263-aminobutyryl-CoA ammonia lyaseAdd BLAST126

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi499177.CLOST_1385.

Structurei

3D structure databases

SMRiE3PRK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KAL family.Curated

Phylogenomic databases

eggNOGiENOG4108UYI. Bacteria.
ENOG4111IUJ. LUCA.
HOGENOMiHOG000221727.
KOiK18014.
OMAiEFLAPVY.
OrthoDBiPOG091H0685.

Family and domain databases

InterProiView protein in InterPro
IPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
PfamiView protein in Pfam
PF03061. 4HBT. 1 hit.
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

E3PRK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVLKIRMS AHDAHYGGGL VDGARMLQLF GDVATELLIM NDGDEGLFKA
60 70 80 90 100
YDMVEFMAPV FAGDYIEVEG SITEQGNTSR KMIFEARKVI VPRTDINDSA
110 120
CDVLETPIVV CRASGTCVVP KDKQRK
Length:126
Mass (Da):13,845
Last modified:January 11, 2011 - v1
Checksum:i877ECFDE414D3076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565809 Genomic DNA. Translation: CBH21505.1.

Genome annotation databases

EnsemblBacteriaiCBH21505; CBH21505; CLOST_1385.
KEGGicst:CLOST_1385.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKAL_ACESD
AccessioniPrimary (citable) accession number: E3PRK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: January 11, 2011
Last modified: June 7, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families