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Protein

3-aminobutyryl-CoA ammonia lyase

Gene

kal

Organism
Clostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the anaerobic fermentation of lysine. Catalyzes the deamination of L-3-aminobutyryl-CoA to produce crotonoyl-CoA.By similarity

Catalytic activityi

L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3.By similarity

Pathwayi: L-lysine degradation via acetate pathway

This protein is involved in the pathway L-lysine degradation via acetate pathway, which is part of Amino-acid degradation.By similarity
View all proteins of this organism that are known to be involved in the pathway L-lysine degradation via acetate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciCSTI499177:GJE9-1434-MONOMER.
UniPathwayiUPA00870.

Names & Taxonomyi

Protein namesi
Recommended name:
3-aminobutyryl-CoA ammonia lyaseBy similarity (EC:4.3.1.14By similarity)
Alternative name(s):
3-aminobutyryl-CoA deaminaseBy similarity
Gene namesi
Name:kalBy similarity
Ordered Locus Names:CLOST_1385
OrganismiClostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654)
Taxonomic identifieri499177 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeAcetoanaerobium
Proteomesi
  • UP000007041 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169781 – 1263-aminobutyryl-CoA ammonia lyaseAdd BLAST126

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi499177.CLOST_1385.

Family & Domainsi

Sequence similaritiesi

Belongs to the KAL family.Curated

Phylogenomic databases

eggNOGiENOG4108UYI. Bacteria.
ENOG4111IUJ. LUCA.
HOGENOMiHOG000221727.
KOiK18014.
OMAiEFLAPVY.
OrthoDBiPOG091H0685.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
[Graphical view]
PfamiPF03061. 4HBT. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

E3PRK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVLKIRMS AHDAHYGGGL VDGARMLQLF GDVATELLIM NDGDEGLFKA
60 70 80 90 100
YDMVEFMAPV FAGDYIEVEG SITEQGNTSR KMIFEARKVI VPRTDINDSA
110 120
CDVLETPIVV CRASGTCVVP KDKQRK
Length:126
Mass (Da):13,845
Last modified:January 11, 2011 - v1
Checksum:i877ECFDE414D3076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565809 Genomic DNA. Translation: CBH21505.1.

Genome annotation databases

EnsemblBacteriaiCBH21505; CBH21505; CLOST_1385.
KEGGicst:CLOST_1385.
PATRICi42273405. VBICloSti32817_1374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP565809 Genomic DNA. Translation: CBH21505.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi499177.CLOST_1385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBH21505; CBH21505; CLOST_1385.
KEGGicst:CLOST_1385.
PATRICi42273405. VBICloSti32817_1374.

Phylogenomic databases

eggNOGiENOG4108UYI. Bacteria.
ENOG4111IUJ. LUCA.
HOGENOMiHOG000221727.
KOiK18014.
OMAiEFLAPVY.
OrthoDBiPOG091H0685.

Enzyme and pathway databases

UniPathwayiUPA00870.
BioCyciCSTI499177:GJE9-1434-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
[Graphical view]
PfamiPF03061. 4HBT. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAL_CLOSD
AccessioniPrimary (citable) accession number: E3PRK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.