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Protein

ConoCAP

Gene

conoCAP

Organism
Conus villepinii (Villepin's cone)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ConoCAP-a: In contrast to other members of the CCAP family which are cardio-accelerators, conoCAP-a decreases the heart frequency in Drosophila larvae (26%), rats and zebrafish embryos. It also reduces the blood pressure in rats. It decreases systolic calcium in ventricular cardiac myocytes, indicating that it may act via impairment of intracellular calcium trafficking.
ConoCAP-b: Synthetic conoCAP-b decreases the heart frequency of 23% in Drosphila larvae.
ConoCAP-c: Synthetic conoCAP-c decreases the heart frequency of 12% in Drosphila larvae.

GO - Molecular functioni

GO - Biological processi

  • modulation of heart rate in other organism Source: UniProtKB
  • negative regulation of heart rate in other organism Source: UniProtKB

Keywordsi

Molecular functionCardiotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
ConoCAP
Cleaved into the following 3 chains:
Alternative name(s):
CCAP-vil
Gene namesi
Name:conoCAP
OrganismiConus villepinii (Villepin's cone)
Taxonomic identifieri257347 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85 – 86Missing : Partial loss of activity of conoCAP-a. 2
Mutagenesisi85P → A: Partial loss of activity of conoCAP-a. 1
Mutagenesisi85Missing : Partial loss of activity of conoCAP-a. 1
Mutagenesisi86F → A: Complete loss of activity of conoCAP-a. 1
Mutagenesisi87C → A: Complete loss of activity of conoCAP-a. 1 Publication1
Mutagenesisi88N → A: No change of activity of conoCAP-a. 1
Mutagenesisi89S → A: No change of activity of conoCAP-a. 1
Mutagenesisi90F → A: No change of activity of conoCAP-a. 1
Mutagenesisi91G → A: No change of activity of conoCAP-a. 1
Mutagenesisi92C → A: Complete loss of activity of conoCAP-a. 1 Publication1
Mutagenesisi93 – 94Missing : No change of activity of conoCAP-a. 2
Mutagenesisi93Y → A: No change of activity of conoCAP-a. 1
Mutagenesisi94N → A: No change of activity of conoCAP-a. 1
Mutagenesisi94Missing : No change of activity of conoCAP-a. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000040595522 – 48Sequence analysisAdd BLAST27
PeptideiPRO_000040595651 – 60ConoCAP-bCurated10
PropeptideiPRO_000040595763 – 82Sequence analysisAdd BLAST20
PeptideiPRO_000040595885 – 94ConoCAP-a10
PropeptideiPRO_000040595998 – 160Sequence analysisAdd BLAST63
PeptideiPRO_0000405960163 – 173ConoCAP-cCuratedAdd BLAST11
PropeptideiPRO_0000405961177 – 207Sequence analysisAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 59Curated
Modified residuei60Glycine amide1 Publication1
Disulfide bondi87 ↔ 92
Modified residuei94Asparagine amide1 Publication1
Disulfide bondi165 ↔ 171Curated
Modified residuei173Glycine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiE3PQQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E3PQQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLGHVLFV ILLPVLLPVA ADDPDDQMLS QISLPSSSRS EYDDNDVSKR
60 70 80 90 100
VFCNGFTGCG GRHRDRSRRQ ERYGKRLIPV LAKRPFCNSF GCYNGKRSLS
110 120 130 140 150
GAGPALSTPV DPSRNNKART MARMLDAAAS ARHEQQQQLL QQREQRGLES
160 170 180 190 200
RDPAASGDLS KRLFCNGYGG CRGGKRTLYS PWLERMNEVA DDRSARNALC

TRLGWRE
Length:207
Mass (Da):23,089
Last modified:January 11, 2011 - v1
Checksum:i18E2D2EE1128C484
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164F → L in CBM40422 (PubMed:20923766).Curated1

Mass spectrometryi

Molecular mass is 1148.6 Da from positions 85 - 94. Determined by MALDI. Monoisotopic.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN868446 mRNA. Translation: CBM40422.1.
FN868447 mRNA. Translation: CBM40423.1.

Entry informationi

Entry nameiCCAP_CONVL
AccessioniPrimary (citable) accession number: E3PQQ8
Secondary accession number(s): E3PQQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 11, 2011
Last modified: November 22, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing