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E3L8A5

- KEX1_PUCGT

UniProt

E3L8A5 - KEX1_PUCGT

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, PGTG_18559
Organism
Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei228 – 2281 By similarity
Active sitei423 – 4231 By similarity
Active sitei481 – 4811 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PGTG_18559
OrganismiPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Taxonomic identifieri418459 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaePuccinia
ProteomesiUP000008783: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 559Lumenal Reviewed prediction
Transmembranei560 – 58021Helical; Reviewed prediction
Add
BLAST
Topological domaini581 – 65676Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 656Pheromone-processing carboxypeptidase KEX1PRO_0000411942
Signal peptidei1 – ? Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi470 – 4701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi531 – 5311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi559 – 5591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 426Poly-Ser
Compositional biasi53 – 564Poly-Thr
Compositional biasi62 – 654Poly-Lys
Compositional biasi607 – 6115Poly-His

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E3L8A5-1 [UniParc]FASTAAdd to Basket

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MSSFQSATTR QGLHRRNMNS ETPQSEFIQR LRRSPPSESS SSTPSSSTTT    50
SSTTTTSNTS GKKKKTAPSA SDFYVPSLPG QPKDSQLILY AGHLSFSPPD 100
TTIEPEKDSY GFFFLNKARH IANRPVLLVW LNGGPGCSSF DGSLMEVGPL 150
RMVLKGDGTL KEVDAAWNEY ANMLFIDQPT GTGYSYGPKP NYVHELDVSS 200
ANLVNLLARF FKIFPEYQQM DLYICGESFA GQYIPYLAQA ILDTNIISAP 250
LKGIMIGNGW IDPINQYLAY PEFAFKVGLV NPSSKAADLV NEELKKCTEW 300
IDSNSTTPIH IEACEGILSA ITDSTVQTVN SQKMCLNMYD VRLVDSYPAC 350
GLTWPPDLAD ITPYLSRTDV KQALHAQDHA ADWVECEAKV GNNFWAKTSQ 400
PSVTLFPKLL DKIKILLFSG DQDLICCHTG TERMIDHLTW AGHQGWTSQA 450
INQPWKVNGS YAGLWKEERN LTYVLVANAS HMAPYDVPYV TQDMLVRFLG 500
IDVMTAAGPA AQITSRIGEE TATKVNRVVM NETKLGQEGS GTTGLAMTSG 550
PVHDENYYNA SSAMLFLTLV GLVVGLIFFV RRRLRRDGHG DFAHHPSDET 600
EIILKNHHHH HLSPDSSLPR SARDRQFQPV PTDDLDDHHL HPNLPSNNTS 650
YQDLPR 656
Length:656
Mass (Da):72,697
Last modified:October 3, 2012 - v2
Checksum:i0FD95B1854B5F6CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS178373 Genomic DNA. Translation: EFP92780.2.
RefSeqiXP_003337199.2. XM_003337151.2.

Genome annotation databases

EnsemblFungiiEFP92780; EFP92780; PGTG_18559.
GeneIDi10542492.
KEGGipgr:PGTG_18559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS178373 Genomic DNA. Translation: EFP92780.2 .
RefSeqi XP_003337199.2. XM_003337151.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFP92780 ; EFP92780 ; PGTG_18559 .
GeneIDi 10542492.
KEGGi pgr:PGTG_18559.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CRL 75-36-700-3 / race SCCL.

Entry informationi

Entry nameiKEX1_PUCGT
AccessioniPrimary (citable) accession number: E3L8A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 22 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi