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E3L8A5

- KEX1_PUCGT

UniProt

E3L8A5 - KEX1_PUCGT

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei228 – 2281PROSITE-ProRule annotation
    Active sitei423 – 4231PROSITE-ProRule annotation
    Active sitei481 – 4811PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:PGTG_18559
    OrganismiPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
    Taxonomic identifieri418459 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaePuccinia
    ProteomesiUP000008783: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 656Pheromone-processing carboxypeptidase KEX1PRO_0000411942
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini? – 559LumenalSequence Analysis
    Topological domaini581 – 65676CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei560 – 58021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 426Poly-Ser
    Compositional biasi53 – 564Poly-Thr
    Compositional biasi62 – 654Poly-Lys
    Compositional biasi607 – 6115Poly-His

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E3L8A5-1 [UniParc]FASTAAdd to Basket

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    MSSFQSATTR QGLHRRNMNS ETPQSEFIQR LRRSPPSESS SSTPSSSTTT    50
    SSTTTTSNTS GKKKKTAPSA SDFYVPSLPG QPKDSQLILY AGHLSFSPPD 100
    TTIEPEKDSY GFFFLNKARH IANRPVLLVW LNGGPGCSSF DGSLMEVGPL 150
    RMVLKGDGTL KEVDAAWNEY ANMLFIDQPT GTGYSYGPKP NYVHELDVSS 200
    ANLVNLLARF FKIFPEYQQM DLYICGESFA GQYIPYLAQA ILDTNIISAP 250
    LKGIMIGNGW IDPINQYLAY PEFAFKVGLV NPSSKAADLV NEELKKCTEW 300
    IDSNSTTPIH IEACEGILSA ITDSTVQTVN SQKMCLNMYD VRLVDSYPAC 350
    GLTWPPDLAD ITPYLSRTDV KQALHAQDHA ADWVECEAKV GNNFWAKTSQ 400
    PSVTLFPKLL DKIKILLFSG DQDLICCHTG TERMIDHLTW AGHQGWTSQA 450
    INQPWKVNGS YAGLWKEERN LTYVLVANAS HMAPYDVPYV TQDMLVRFLG 500
    IDVMTAAGPA AQITSRIGEE TATKVNRVVM NETKLGQEGS GTTGLAMTSG 550
    PVHDENYYNA SSAMLFLTLV GLVVGLIFFV RRRLRRDGHG DFAHHPSDET 600
    EIILKNHHHH HLSPDSSLPR SARDRQFQPV PTDDLDDHHL HPNLPSNNTS 650
    YQDLPR 656
    Length:656
    Mass (Da):72,697
    Last modified:October 3, 2012 - v2
    Checksum:i0FD95B1854B5F6CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS178373 Genomic DNA. Translation: EFP92780.2.
    RefSeqiXP_003337199.2. XM_003337151.2.

    Genome annotation databases

    EnsemblFungiiEFP92780; EFP92780; PGTG_18559.
    GeneIDi10542492.
    KEGGipgr:PGTG_18559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS178373 Genomic DNA. Translation: EFP92780.2 .
    RefSeqi XP_003337199.2. XM_003337151.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFP92780 ; EFP92780 ; PGTG_18559 .
    GeneIDi 10542492.
    KEGGi pgr:PGTG_18559.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CRL 75-36-700-3 / race SCCL.

    Entry informationi

    Entry nameiKEX1_PUCGT
    AccessioniPrimary (citable) accession number: E3L8A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 23 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3